Reactome: ATP [cytosol]

Details

Participates in processes
Name	ATP Adenosine 5'-triphosphate
Stable identifier	REACT_2812.1
Reference entity	ATP [ChEBI:15422]
Links to compound in external databases	ChEBI:15422 COMPOUND:C00002 PubChem Substance:8143180
Cellular compartment	cytosol GO
Is represented by generalisation(s)	Purine nucleotide [cytosol]
Component of	Cytochrome C:Apaf-1:ATP:Procaspase-9 [cytosol] actin:ATP [cytosol] CCT/TriC(ATP):unfolded tubulin complex [cytosol] CCT/TriC(ATP) [cytosol] ATP Bound Myosin Complex [cytosol] CCT/TriC(ATP) [cytosol] actin:ATP [cytosol] Beta actin:ATP [cytosol] ATP Bound Smooth Muscle Myosin Complex [cytosol] actin:ATP (name copied from entity in Homo sapiens) [cytosol] ... List all 211 items
Cell Cycle Checkpoints - G2/M Checkpoints - G2/M DNA replication checkpoint - Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes [Homo sapiens] Integrin cell surface interactions - Integrin alphaIIbbeta3 signaling - Auto-phosphorylation of FADK1 at Y397 [Homo sapiens] - Phosphorylation of pFADK1 by SRC [Homo sapiens] - p130Cas linkage to MAPK signaling for integrins - Phosphorylation of p130Cas by Src-FAK complex [Homo sapiens] - Autophosphorylation of c-src [Homo sapiens] Cell junction organization - Cell-cell junction organization - Adherens junctions interactions - Interaction of Afadin with F-actin [Homo sapiens] - Cell-extracellular matrix interactions - MigFilin associates with Filamin and F-actin [Homo sapiens] Inhibition of HSL - Phosphorylation of PDE3B [Homo sapiens] Apoptosis - Intrinsic Pathway for Apoptosis - Apoptotic factor-mediated response - Cytochrome c-mediated apoptotic response - Formation of apoptosome - Cytochrome C:Apaf-1 binds Procaspase-9 [Homo sapiens] - Cleavage of Procaspase-9 to Caspase-9 [Homo sapiens] - Activation of caspases through apoptosome-mediated cleavage - Cleavage of Procaspase-3 by the apoptosome [Homo sapiens] - Cleavage of Procaspase-7 by the apoptosome [Homo sapiens] - Apoptotic execution phase - Stimulation of the cell death response by PAK-2p34 - Autophosphorylation of PAK-2p34 in the activation loop [Homo sapiens] - Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197 [Homo sapiens] - Regulation of Apoptosis - Role of DCC in regulating apoptosis - Activation of caspase-3 [Homo sapiens] Signaling by Wnt - Degradation of beta-catenin by the destruction complex - Beta-catenin phosphorylation cascade - Phosphorylation of beta-catenin at Ser45 by CK1 alpha [Homo sapiens] - Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 [Homo sapiens] - Phosphoryation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3 [Homo sapiens] - Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 [Homo sapiens] - Phosphorylation of APC component of the destruction complex [Homo sapiens] Signaling by FGFR - FGFR ligand binding and activation - FGFR1 ligand binding and activation - FGFR1b ligand binding and activation - Autocatalytic phosphorylation of FGFR1b [Homo sapiens] - FGFR1c ligand binding and activation - Autocatalytic phosphorylation of FGFR1c [Homo sapiens] - FGFR1c and Klotho ligand binding and activation - Autocatalytic phosphorylation of Klotho-bound FGFR1c [Homo sapiens] - FGFR2 ligand binding and activation - FGFR2b ligand binding and activation - Autocatalytic phosphorylation of FGFR2b [Homo sapiens] - FGFR2c ligand binding and activation - Autocatalytic phosphorylation of FGFR2c [Homo sapiens] - FGFR3 ligand binding and activation - FGFR3b ligand binding and activation - Autocatalytic phosphorylation of FGFR3b [Homo sapiens] - FGFR3c ligand binding and activation - Autocatalytic phosphorylation of FGFR3c [Homo sapiens] - FGFR4 ligand binding and activation - Autocatalytic phosphorylation of FGFR4 [Homo sapiens] - Downstream signaling of activated FGFR - FRS2-mediated cascade - Phosphorylation of FRS2-alpha by activated FGFR [Homo sapiens] - SHP2 is phosphorylated by activated FGFR [Homo sapiens] - Phospholipase C-mediated cascade - PLC gamma phosphorylation by FGFR [Homo sapiens] - SHC-mediated cascade - SHC becomes phosphorylated [Homo sapiens] - PI-3K cascade - PIP2 conversion to PIP3 [Homo sapiens] Cell Cycle, Mitotic - Mitotic G1-G1/S phases - G1 Phase - Cyclin D associated events in G1 - Formation of Cyclin D:Cdk4/6 complexes [Homo sapiens] - S Phase - Synthesis of DNA - Switching of origins to a post-replicative state - CDK-mediated phosphorylation and removal of Cdc6 - Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex [Homo sapiens] - Regulation of DNA replication - Removal of licensing factors from origins - CDK-mediated phosphorylation and removal of Cdc6 - Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex [Homo sapiens] - Mitotic G2-G2/M phases - G2/M Transition - Cyclin A/B1 associated events during G2/M transition - Myt-1 mediated phosphorylation of Cyclin A:Cdc2 [Homo sapiens] - Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes [Homo sapiens] - Phosphorylation of Cyclin B1 in the CRS domain [Homo sapiens] - Cyclin B2 mediated events - Phosphorylation of proteins involved in G2/M transition by active Cyclin B2:Cdc2 complexes [Homo sapiens] - Centrosome maturation - Loss of proteins required for interphase microtubule organization from the centrosome - Loss of Nlp from mitotic centrosomes - Plk1-mediated phosphorylation of Nlp [Homo sapiens] Metabolism of nucleotides - Purine metabolism - Purine ribonucleoside monophosphate biosynthesis - FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi [Homo sapiens] - FGAM + ATP => AIR + ADP + Pi [Homo sapiens] - XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate [Homo sapiens] - CAIR + Aspartate + ATP => SAICAR + ADP + Pi [Homo sapiens] - 5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi [Homo sapiens] - Purine salvage - (2'-deoxy)adenosine + ATP => (d)AMP + ADP [ADK] [Homo sapiens] - deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP [DCK] [Homo sapiens] - Pyrimidine metabolism - Pyrimidine biosynthesis - L-glutamine + 2 ATP + HCO3- + H2O => carbamoyl phosphate + L-glutamate + 2 ADP + orthophosphate [Homo sapiens] - Pyrimidine salvage reactions - cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] [Homo sapiens] - cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] [Homo sapiens] - thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1] [Homo sapiens] - (2'-deoxy)cytidine + ATP => (d)CMP + ADP [DCK] [Homo sapiens] - Synthesis and interconversion of nucleotide di- and triphosphates - (d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP [CMPK1] [Homo sapiens] - (d)NDP + ATP <=> (d)NTP + ADP [NME1,2,3] [Homo sapiens] - UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] [Homo sapiens] - (d)NTP + ADP <=> (d)NDP + ATP [NME1,2,3] [Homo sapiens] - dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] [Homo sapiens] - (d)GMP + ATP <=> (d)GDP + ADP [GUK1] [Homo sapiens] - (d)AMP + ATP <=> (d)ADP + ADP [AK1] [Homo sapiens] - (d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP [CMPK1] [Homo sapiens] - dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK] [Homo sapiens] - (d)GDP + ADP <=> (d)GMP + ATP [GUK1] [Homo sapiens] - (d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP [AK5] [Homo sapiens] - (d)AMP or (d)CMP + ATP <=> (d)ADP or (d)CDP + ADP [AK5] [Homo sapiens] - (d)ADP + ADP <=> (d)AMP + ATP [AK1] [Homo sapiens] - ADP + ADP <=> AMP + ATP [AK2] [Homo sapiens] - AMP + ATP <=> ADP + ADP [AK2] [Homo sapiens] - UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] [Homo sapiens] Signalling by NGF - p75 NTR receptor-mediated signalling - Cell death signalling via NRAGE, NRIF and NADE - NRAGE signals death through JNK - NRAGE activates JNK [Homo sapiens] - JNK phosphorylates BIM, BAD and other targets [Homo sapiens] - GTP-bound RAC contributes to JNK activation [Homo sapiens] - NRIF signals cell death from the nucleus - NRIF and TRAF6 may activate JNK [Homo sapiens] - p75NTR signals via NF-kB - p75NTR recruits signalling complexes - IRAK is activated [Homo sapiens] - NF-kB is activated and signals survival - IKKbeta is activated [Homo sapiens] - IKKbeta phosphorylates IkB causing NF-kB to dissociate [Homo sapiens] - NGF signalling via TRKA from the plasma membrane - Activation of TRKA receptors - TRKA activation by NGF - TrkA receptor autophosphorylates [Homo sapiens] - Signalling to ERKs - Signalling to RAS - RAF activation - Stabilisation of RAF by further phosphorylation [Homo sapiens] - MAP kinase cascade - MEK activation - RAF phosphorylates MEK - RAF1 phosphorylates MEK1 [Homo sapiens] - RAF1 phosphorylates MEK2 [Homo sapiens] - ERK activation - ERK1 activation - Inactivation of MEK1 by p34cdc2 [Homo sapiens] - MEK1 phosphorylates ERK-1 [Homo sapiens] - ERK2 activation - MEK2 phosphorylates ERK-2 [Homo sapiens] - p38MAPK events - Binding and activation of MAP Kinase [Homo sapiens] - MAP kinase activates MAPKAPK2, MAPKAPK3 and MSK1 [Homo sapiens] - Signalling to p38 via RIT and RIN - RAF activation - Stabilisation of RAF by further phosphorylation [Homo sapiens] - MAP kinase cascade - MEK activation - RAF phosphorylates MEK - RAF1 phosphorylates MEK1 [Homo sapiens] - RAF1 phosphorylates MEK2 [Homo sapiens] - ERK activation - ERK1 activation - Inactivation of MEK1 by p34cdc2 [Homo sapiens] - MEK1 phosphorylates ERK-1 [Homo sapiens] - ERK2 activation - MEK2 phosphorylates ERK-2 [Homo sapiens] - Prolonged ERK activation events - Frs2-mediated activation - MAP kinase cascade - MEK activation - RAF phosphorylates MEK - RAF1 phosphorylates MEK1 [Homo sapiens] - RAF1 phosphorylates MEK2 [Homo sapiens] - ERK activation - ERK1 activation - Inactivation of MEK1 by p34cdc2 [Homo sapiens] - MEK1 phosphorylates ERK-1 [Homo sapiens] - ERK2 activation - MEK2 phosphorylates ERK-2 [Homo sapiens] - ARMS-mediated activation - ARMS is phosphorylated by active TrkA receptor [Homo sapiens] - MAP kinase cascade - MEK activation - RAF phosphorylates MEK - RAF1 phosphorylates MEK1 [Homo sapiens] - RAF1 phosphorylates MEK2 [Homo sapiens] - ERK activation - ERK1 activation - Inactivation of MEK1 by p34cdc2 [Homo sapiens] - MEK1 phosphorylates ERK-1 [Homo sapiens] - ERK2 activation - MEK2 phosphorylates ERK-2 [Homo sapiens] - PLC-gamma1 signalling - TrkA phosphorylates PLCG1 [Homo sapiens] - DAG stimulates protein kinase C-delta [Homo sapiens] - CaM pathway - Calmodulin induced events - PKA-mediated phosphorylation of CREB - PKA activation - Adenylate cyclase produces cAMP [Homo sapiens] - PKC phosphorylates GRK2 [Homo sapiens] - PI3K/AKT signalling - PDK1 phosphorylates AKT at T308 [Homo sapiens] - TORC2 (mTOR) phosphorylates AKT at S473 [Homo sapiens] - AKT phosphorylates targets in the cytosol - AKT phosphorylates BAD [Homo sapiens] - AKT phosphorylates GSK3 [Homo sapiens] - AKT phosphorylates caspase-9 [Homo sapiens] - AKT phosphorylates MDM2 [Homo sapiens] - AKT phosphorylates IKKalpha [Homo sapiens] - AKT phosphorylates p21Cip1 and p27Kip1 [Homo sapiens] - AKT phosphorylates TSC2, inhibiting it [Homo sapiens] - AKT phosphorylates PRAS40 [Homo sapiens] - PI3K produces PIP3 and other phosphatidyl inositides [Homo sapiens] - TRKA phosphorylates IRS [Homo sapiens] - Signalling to STAT3 - STAT3 activation [Homo sapiens] - Signalling to ERK5 - ERK5 is activated [Homo sapiens] Axon guidance - Semaphorin interactions - Sema4D in semaphorin signaling - Sema4D mediated inhibition of cell attachment and migration - SEMA4D interacts with Plexin-B1:Met [Homo sapiens] - Sema4D induced cell migration and growth-cone collapse - SEMA4D interacts with Plexin-B1:ErbB2 [Homo sapiens] - Myosin regulatory light chain phosphorylation by ROCK [Homo sapiens] - LIM kinase phosphorylation by ROCK [Homo sapiens] - SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion - Phosphorylation of Plexin-A [Homo sapiens] - Sema3A PAK dependent Axon repulsion - Autophosphorylation of PAK [Homo sapiens] - Phosphorylation of LIMK-1 by PAK [Homo sapiens] - Transphosphorylation of pLIMK1 [Homo sapiens] - Phosphorylation of cofilin by LIMK-1 [Homo sapiens] - CRMPs in Sema3A signaling - Recruitment and activation of Cdk5 [Homo sapiens] - Phosphorylation of CRMPs by Cdk5 [Homo sapiens] - Phosphorylation of CRMPs by GSK3beta [Homo sapiens] - Tyrosine phosphorylation of CRMPs by Fes [Homo sapiens] - NCAM signaling for neurite out-growth - Autophosphorylation of NCAM1 bound Fyn [Homo sapiens] - Recruitment of FAK to NCAM1:Fyn in lipid rafts [Homo sapiens] - Phosphorylation of FAK by Src kinase [Homo sapiens] - MAP kinase cascade - MEK activation - RAF phosphorylates MEK - RAF1 phosphorylates MEK1 [Homo sapiens] - RAF1 phosphorylates MEK2 [Homo sapiens] - ERK activation - ERK1 activation - Inactivation of MEK1 by p34cdc2 [Homo sapiens] - MEK1 phosphorylates ERK-1 [Homo sapiens] - ERK2 activation - MEK2 phosphorylates ERK-2 [Homo sapiens] - RAF activation - Stabilisation of RAF by further phosphorylation [Homo sapiens] - Netrin-1 signaling - DCC mediated attractive signaling - Phosphorylation of FADK1 [Homo sapiens] - Phosphorylation of DCC by Fyn [Homo sapiens] - Netrin mediated repulsion signals - Phosphorylation of Unc5C [Homo sapiens] - Phosphorylation and activation of Ezrin [Homo sapiens] - Role of second messengers in netrin-1 signaling - Phosphorylation of PLCgamma by Netrin-1 [Homo sapiens] - Signaling by Robo receptor - Role of Abl in Robo-Slit signaling - Phosphorylation of Rob1 by Abl kinase [Homo sapiens] - L1CAM interactions - Recycling pathway of L1 - Linkage of L1 with treadmilling F-actin [Homo sapiens] - Dephosphorylation of pL1 (Y1176) [Homo sapiens] - Shootin-1 links L1 and retrograde actin flow [Homo sapiens] - Phosphorylation of L1 by p90rsk [Homo sapiens] - Phosphorylation of L1 by ERK [Homo sapiens] - Phosphorylation of L1 by SRC [Homo sapiens] - Interaction between L1 and Ankyrins - L1 linked to actin cytoskeleton by ankyrin [Homo sapiens] - Ankyrins link voltage-gated sodium and potassium channels to spectrin and L1 [Homo sapiens] - Phosphorylation of Y1229 in L1 [Homo sapiens] - Signal transduction by L1 - Phosphorylation of VAV2 [Homo sapiens] - Interaction of PAK1 with Rac1-GTP [Homo sapiens] - MEK1 phosphorylates ERK-1 [Homo sapiens] - MEK2 phosphorylates ERK-2 [Homo sapiens] - Phosphorylation of L1 by CK-II [Homo sapiens] - Phosphorylation of L1 by ERK [Homo sapiens] - Phosphorylation of L1 by p90rsk [Homo sapiens] - Phosphorylation of L1 by EPHB2 [Homo sapiens] - Neurofascin interactions - Phosphorylation of Neurofascin [Homo sapiens] Axon guidance - Semaphorin interactions - CRMPs in Sema3A signaling - Recruitment and activation of Cdk5 [Gallus gallus] Diabetes pathways - Unfolded Protein Response - Activation of Chaperones by IRE1alpha - Autophosphorylation of IRE1 dimer [Homo sapiens] - PERK regulated gene expression - Phosphorylation of eIF2-alpha by PERK [Homo sapiens] - Regulation of Insulin Secretion - ADP-ATP translocase maintains a high ADP:ATP ratio in the matrix [Homo sapiens] - Closing of Inward Rectifying, ATP-sensitive Potassium Channels (KATP channels) [Homo sapiens] - Regulation of Insulin Secretion by Glucagon-like Peptide-1 - Production of Cyclic AMP by Activated Adenylyl Cyclase [Homo sapiens] - Regulation of Insulin Secretion by Acetylcholine - Phosphorylation of MARCKS by Protein kinase C, alpha type [Homo sapiens] Axon guidance - Semaphorin interactions - Sema3A PAK dependent Axon repulsion - Phosphorylation of cofilin by LIMK-1 [Mus musculus] - NCAM signaling for neurite out-growth - Autophosphorylation of NCAM1 bound Fyn [Mus musculus] Metabolism of lipids and lipoproteins - Lipid digestion, mobilization, and transport - Trafficking of dietary sterols - ABCG5:ABCG8-mediated export of cholesterol and phytosterols [Homo sapiens] - Lipoprotein metabolism - HDL-mediated lipid transport - ABCA1-mediated transport of intracellular cholesterol to the cell surface [Homo sapiens] - ABCA1-mediated transport of intracellular phospholipid to the cell surface [Homo sapiens] - ABCG1-mediated transport of intracellular cholesterol to the cell surface [Homo sapiens] - Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis - hormone-sensitive lipase (HSL) + 2 ATP -> phosphorylated HSL + 2 ADP [Homo sapiens] - perilipin + 2 ATP -> phosphorylated perilipin + 2 ADP [Homo sapiens] - Fatty acid, triacylglycerol, and ketone body metabolism - Triglyceride Biosynthesis - Fatty Acyl-CoA Biosynthesis - Generation of Cytoplasmic Acetyl CoA from Citrate [Homo sapiens] - acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate [Homo sapiens] - Synthesis of very long-chain fatty acyl-CoAs - palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL1] [Homo sapiens] - palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL3] [Homo sapiens] - arachidonate + CoASH + ATP => arachidonoyl-CoA + AMP + pyrophosphate + H2O [ACSL4] [Homo sapiens] - palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL5] [Homo sapiens] - palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL6] [Homo sapiens] - Conversion of Glycerol to Glycerol-3-phosphate [Homo sapiens] - Import of palmitoyl-CoA into the mitochondrial matrix - Formation of Malonyl-CoA from Acetyl-CoA (muscle) [Homo sapiens] - pAMPK inactivates ACC2 inhibiting malonyl-CoA synthesis [Homo sapiens] - Peroxisomal lipid metabolism - Alpha-oxidation of phytanate - PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP [Homo sapiens] - Sphingolipid metabolism - CERT + ATP => monophospho-CERT + ADP [Homo sapiens] - monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP [Homo sapiens] - sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP [Homo sapiens] - sphingosine +ATP => sphingosine 1-phosphate + ADP [Homo sapiens] - Cholesterol biosynthesis - Mevalonate is phosphorylated to mevalonate-5-phosphate [Homo sapiens] - Mevalonate-5-phosphate is further phosphorylated. [Homo sapiens] - Mevalonate-5-pyrophosphate is decarboxylated [Homo sapiens] - Bile acid and bile salt metabolism - Synthesis of bile acids and bile salts - Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol - THCA is conjugated with Coenzyme A (SLC27A2 VLCS) [Homo sapiens] - DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) [Homo sapiens] - THCA is conjugated with Coenzyme A (SLC27A5 BACS) [Homo sapiens] - DHCA is conjugated with Coenzyme A (SLC27A5 BACS) [Homo sapiens] - Transport (efflux) of bile salts by ABCB11 (bile salt export pump) [Homo sapiens] - Synthesis of bile acids and bile salts via 24-hydroxycholesterol - TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) [Homo sapiens] - 3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) [Homo sapiens] - TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) [Homo sapiens] - 3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) [Homo sapiens] - Recycling of bile acids and salts - Transport (efflux) of bile salts by ABCC3 (MRP3) [Homo sapiens] - Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) [Homo sapiens] - Transport (efflux) of bile salts by ABCB11 (bile salt export pump) [Homo sapiens] Metabolism of proteins - Translation - Eukaryotic Translation Initiation - Cap-dependent Translation Initiation - Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S - Cap-bound mRNA is activated by helicases [Homo sapiens] - Ribosomal scanning and start codon recognition - Ribosomal scanning [Homo sapiens] - Protein folding - Chaperonin-mediated protein folding - Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding - Formation of tubulin folding intermediates by CCT/TriC - ADP is exchanged for ATP in the (ADP:CCT/TriC):tubulin complex [Homo sapiens] - Hydrolysis of ATP and release of tubulin folding intermediate from CCT/TriC [Homo sapiens] - Folding of actin by CCT/TriC - Exchange of ADP for ATP in CCT/TriC:actin complex [Homo sapiens] - Hydrolysis of ATP and release of folded actin from CCT/TriC [Homo sapiens] Membrane Trafficking - trans-Golgi Network Vesicle Budding - Clathrin derived vesicle budding - Golgi Associated Vesicle Biogenesis - trans-Golgi Network Derived Vesicle Uncoating [Homo sapiens] - Lysosome Vesicle Biogenesis - trans-Golgi Network Derived Lysosomal Vesicle Uncoating [Homo sapiens] - Gap junction trafficking and regulation - Regulation of gap junction activity - c-src mediated regulation of Cx43 function and closure of gap junctions - Phosphorylation of Cx43 by c-src [Homo sapiens] Metabolism of nitric oxide - eNOS activation and regulation - eNOS activation - Akt phosphorylates eNOS [Homo sapiens] Hemostasis - Formation of Platelet plug - Platelet Activation - Platelet activation triggers - Signal amplification - ADP signalling through P2Y purinoceptor 1 - P2Y purinoceptor 1 activates MAP kinase p38 alpha [Homo sapiens] - Phosphorylation of cPLA2 by MAPK p38 alpha [Homo sapiens] - GPVI-mediated activation cascade - Fyn/Lyn-mediated phosphorylation of FcR1 gamma [Homo sapiens] - Syk activation leads to SLP-76 activation [Homo sapiens] - PI3K alpha, beta, gamma convert PIP2 to PIP3 [Homo sapiens] - PDK1 activates PKC zeta [Homo sapiens] - Effects of PIP2 hydrolysis - DAG kinase produces phosphatidic acid from DAG [Homo sapiens] - Response to elevated platelet cytosolic Ca2+ - Disinhibition of SNARE formation - Phosphorylation of Platelet Sec-1 [Homo sapiens] - Phosphorylation of Syntaxin-4 [Homo sapiens] - Platelet Aggregation (Plug Formation) - Integrin alphaIIbbeta3 signaling - Auto-phosphorylation of FADK1 at Y397 [Homo sapiens] - Phosphorylation of pFADK1 by SRC [Homo sapiens] - p130Cas linkage to MAPK signaling for integrins - Phosphorylation of p130Cas by Src-FAK complex [Homo sapiens] - Autophosphorylation of c-src [Homo sapiens] - Cell surface interactions at the vascular wall - Tie2 Signaling - Trans-phosphorylation of Tie2 [Homo sapiens] - PECAM1 interactions - Phoshorylation of PECAM-1 by Fyn or Lyn or c-Src [Homo sapiens] Phosphorylation of L1 by p90rsk [Homo sapiens] Activated AMPK stimulates fatty-acid oxidation in muscle - Activation of cytosolic AMPK by phosphorylation [Homo sapiens] - pAMPK inactivates ACC2 inhibiting malonyl-CoA synthesis [Homo sapiens] - Formation of Malonyl-CoA from Acetyl-CoA (muscle) [Homo sapiens] - Import of palmitoyl-CoA into the mitochondrial matrix - Formation of Malonyl-CoA from Acetyl-CoA (muscle) [Homo sapiens] - pAMPK inactivates ACC2 inhibiting malonyl-CoA synthesis [Homo sapiens] - palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL1] [Homo sapiens] Transmembrane transport of small molecules - SLC-mediated transmembrane transport - Hexose transport - Glucose transport - GLUT1 + ATP <=> GLUT1:ATP [Homo sapiens] - GLUT1:ATP <=> GLUT1 + ATP [Homo sapiens] - alpha-D-Glucose + ATP => alpha-D-glucose 6-phosphate + ADP [Homo sapiens] ROCK1 activates LIM kinase 2 (rat) [Homo sapiens] Signaling by TGF beta - Type II receptor phosphorylates type I receptor [Homo sapiens] - Activated type I receptor phosphorylates R-SMAD directly [Homo sapiens] Metabolism of amino acids and derivatives - Amino acid synthesis and interconversion (transamination) - aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] [Homo sapiens] - glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] [Homo sapiens] - Urea cycle - ATP + aspartate + citrulline <=> argininosuccinate + AMP + pyrophosphate [Homo sapiens] - Creatine metabolism - creatine + ATP => phosphocreatine + ADP [CKB,CKM] [Homo sapiens] - creatine + ATP => phosphocreatine + ADP [CK octamer] [Homo sapiens] Metabolism of vitamins and cofactors - Metabolism of water-soluble vitamins and cofactors - Vitamin B1 (thiamin) metabolism - Thiamin is pyrophosphorylated [Homo sapiens] - Vitamin B2 (riboflavin) metabolism - Riboflavin is phosphorylated to FMN [Homo sapiens] - FMN is futher phosphorylated to FAD [Homo sapiens] - Vitamin B5 (pantothenate) metabolism - Coenzyme A biosynthesis - Adenylation of phosphopantetheine [Homo sapiens] - Phosphorylation of dephospho-CoA to produce CoA [Homo sapiens] - Pantothenate is phosphorylated [PANK2] [Homo sapiens] - Condensation of phosphopantothenate with cysteine [Homo sapiens] - Pantothenate is phosphorylated [PANK1;3;4] [Homo sapiens] - Nicotinate metabolism - Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT2] [Homo sapiens] - Amidation of deamino-NAD+ to NAD+ [Homo sapiens] - NAD+ is phosphorylated to NADP+ [Homo sapiens] - Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT3] [Homo sapiens] - Metabolism of folate and pterines - Conversion of cytosolic THF to THF-polyglutamate [Homo sapiens] - THF polyglutamate + formate + ATP => 10-formylTHF polyglutamate + ADP + orthophosphate [Homo sapiens] - Conversion of cytosolic 5-methyltetrahydrofolate (5-methylTHF) to 5-methylTHF-polyglutamate [Homo sapiens] Signaling by PDGF - Autophosphorylation of PDGF beta receptors [Homo sapiens] - Autophosphorylation of PDGF alpha receptors [Homo sapiens] - Autophosphorylation of PDGF alpha/beta receptors [Homo sapiens] - Down-stream signal transduction - PI3K catalyses the phosphorylation of PIP2 to PIP3 [Homo sapiens] - Activation of Src [Homo sapiens] - RAF activation - Stabilisation of RAF by further phosphorylation [Homo sapiens] - MAP kinase cascade - MEK activation - RAF phosphorylates MEK - RAF1 phosphorylates MEK1 [Homo sapiens] - RAF1 phosphorylates MEK2 [Homo sapiens] - ERK activation - ERK1 activation - Inactivation of MEK1 by p34cdc2 [Homo sapiens] - MEK1 phosphorylates ERK-1 [Homo sapiens] - ERK2 activation - MEK2 phosphorylates ERK-2 [Homo sapiens] Signaling in Immune system - Innate Immunity Signaling - Toll Receptor Cascades - Toll Like Receptor 10 (TLR10) Cascade - MyD88 cascade - First phosphorylation of IRAK1 by IRAK4 bound to activated TLR [Homo sapiens] - Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR [Homo sapiens] - Multiple IRAK1 autophosphorylation steps [Homo sapiens] - Toll Like Receptor 3 (TLR3) Cascade - Viral dsRNA:TLR3:TRIF Complex Activates TBK1/IKK epsilon - Recruitment of human TBK1/IKK epsilon to the Viral dsRNA:TLR3:TRIF Complex followed by their activation [Homo sapiens] - Phosphorylation and Release of IRF3 or IRF7 [Homo sapiens] - Viral dsRNA:TLR3:TRIF Complex Activates RIP1 - RIP1 phosphorylates IKKs [Homo sapiens] - Phospho-IKK Complex phosphorylates IkB within the IkB:NFkB Complex [Homo sapiens] - TRAF6 Mediated Induction of the antiviral cytokine IFN-alpha/beta cascade - Activation of recruited TAK1 within the complex viral dsRNA:TLR3:TRIF:pUb-TRAF6:TAB1:Ub-TAB2:Ub-TAB3: TAK1 [Homo sapiens] - human TAK1 activates NFkB by phosphorylation and activation of IKKs complex - Activated TAK1 mediates phosphorylation of the IKK Complex [Homo sapiens] - Phospho-IKK Complex phosphorylates IkB within the IkB:NFkB Complex [Homo sapiens] - MAP kinases activation in TLR cascade - JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 - Activated TAK1 phosphorylates MKK4/MKK7 [Homo sapiens] - Phosphorylation of human JNKs by activated MKK4/MKK7 [Homo sapiens] - activated TAK1 mediates p38 MAPK activation - activated human TAK1 phosphorylates MKK3/MKK6 [Homo sapiens] - ERK activation - ERK1 activation - Inactivation of MEK1 by p34cdc2 [Homo sapiens] - MEK1 phosphorylates ERK-1 [Homo sapiens] - ERK2 activation - MEK2 phosphorylates ERK-2 [Homo sapiens] - Toll Like Receptor 5 (TLR5) Cascade - MyD88 cascade - First phosphorylation of IRAK1 by IRAK4 bound to activated TLR [Homo sapiens] - Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR [Homo sapiens] - Multiple IRAK1 autophosphorylation steps [Homo sapiens] - Toll Like Receptor 7/8 (TLR7/8) Cascade - MyD88 cascade - First phosphorylation of IRAK1 by IRAK4 bound to activated TLR [Homo sapiens] - Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR [Homo sapiens] - Multiple IRAK1 autophosphorylation steps [Homo sapiens] - Toll Like Receptor 9 (TLR9) Cascade - MyD88 cascade - First phosphorylation of IRAK1 by IRAK4 bound to activated TLR [Homo sapiens] - Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR [Homo sapiens] - Multiple IRAK1 autophosphorylation steps [Homo sapiens] - Toll Like Receptor 4 (TLR4) Cascade - Activated TLR4 signalling - MyD88 cascade - First phosphorylation of IRAK1 by IRAK4 bound to activated TLR [Homo sapiens] - Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR [Homo sapiens] - Multiple IRAK1 autophosphorylation steps [Homo sapiens] - TRAM Cascade - TBK1-mediated phosphorylation of IRF-3 [Homo sapiens] - Toll Like Receptor 2 Cascade - Toll Like Receptor TLR1:TLR2 Cascade - MyD88 cascade - First phosphorylation of IRAK1 by IRAK4 bound to activated TLR [Homo sapiens] - Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR [Homo sapiens] - Multiple IRAK1 autophosphorylation steps [Homo sapiens] - Toll Like Receptor TLR6:TLR2 Cascade - MyD88 cascade - First phosphorylation of IRAK1 by IRAK4 bound to activated TLR [Homo sapiens] - Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR [Homo sapiens] - Multiple IRAK1 autophosphorylation steps [Homo sapiens] - TCR signaling - Phosphorylation of CD3 and TCR zeta chains - Activation of Lck [Homo sapiens] - Phosphorylation of ITAM motifs in CD3 complexes [Homo sapiens] - Inactivation of Lck by Csk [Homo sapiens] - Translocation of ZAP-70 to Immunological synapse - Phosphorylation of ZAP-70 by Lck [Homo sapiens] - Activation of ZAP-70 [Homo sapiens] - Generation of second messenger molecules - Phosphorylation of TBSMs in LAT [Homo sapiens] - Phosphorylation of SLP-76 [Homo sapiens] - Phosphorylation of PLC-gamma1 [Homo sapiens] - Downstream TCR signaling - Change of PKC theta conformation [Homo sapiens] - Phosphorylation of PKC theta [Homo sapiens] - Activation of TAK1-TAB2 complex [Homo sapiens] - Activation of IKK complex [Homo sapiens] - PI3K phosphorylates PIP2 to PIP3 [Homo sapiens] - Phosphorylation of CARMA1 [Homo sapiens] - Phosphorylation of Bcl10 [Homo sapiens] - Activation of NF-kB complex [Homo sapiens] - Costimulation by the CD28 family - CD28 co-stimulation - Phosphorylation of CD28 [Homo sapiens] - CD28 dependent PI3K/Akt signaling - PDK1 phosphorylates AKT at T308 [Homo sapiens] - TORC2 (mTOR) phosphorylates AKT at S473 [Homo sapiens] - AKT interacts and phosphorylates Cot [Homo sapiens] - Akt:pCot phosphorylates NIK [Homo sapiens] - CD28 bound PI3K phosphorylates PIP2 to PIP3 [Homo sapiens] - CD28 dependent Vav1 pathway - Activation of Vav1 [Homo sapiens] - CTLA4 inhibitory signaling - Phosphorylation of CTLA-4 [Homo sapiens] - PD-1 signaling - Phosphorylation of PD-1 [Homo sapiens] - Signaling by Interleukins - Interleukin-1 signaling - Activated TAK1 mediates phosphorylation of the IKK Complex [Homo sapiens] - The IKKB complex phosphorylates NFkB p105 [Homo sapiens] - IRAK4 phosphorylates IRAK1 [Homo sapiens] - IRAK4-activated IRAK1 autophosphorylates [Homo sapiens] - IRAK4 is activated by autophosphorylation [Homo sapiens] - IRAK1 and 4 can phosphorylate Pellino-1 and 2. [Homo sapiens] - TPL2 phosphorylates MEK1, SEK1 [Homo sapiens] - TAK1 phosphorylates MKK6 [Homo sapiens] Opioid Signalling - G-protein mediated events - PLC beta mediated events - Ca-dependent events - CaM pathway - Calmodulin induced events - PKA-mediated phosphorylation of CREB - PKA activation - Adenylate cyclase produces cAMP [Homo sapiens] - PKC phosphorylates GRK2 [Homo sapiens] - Adenylate cyclase activating pathway - Adenylate cyclase converts ATP into cyclic AMP [Homo sapiens] - DARPP-32 events - PKA phosphorylates PDE4B [Homo sapiens] - PKA phosphorylates DARPP-32 on Thr34 [Homo sapiens] Signaling by BMP - Type II receptor phosphorylates type I receptor [Homo sapiens] - Activated type I receptor phosphorylates R-Smad1/5/8 directly [Homo sapiens] Synaptic Transmission - Transmission across Chemical Synapses - Neurotransmitter Release Cycle - Norepinephrine Neurotransmitter Release Cycle - Re-acidification of clathrin sculpted monoamine tranport vesicle lumen [Homo sapiens] - Serotonin Neurotransmitter Release Cycle - Re-acidification of clathrin sculpted monoamine tranport vesicle lumen [Homo sapiens] - Dopamine Neurotransmitter Release Cycle - Synthesis of Dopamine - Re-acidification of clathrin sculpted monoamine tranport vesicle lumen [Homo sapiens] - Re-acidification of clathrin sculpted monoamine tranport vesicle lumen [Homo sapiens] - Acetylcholine Neurotransmitter Release Cycle - Re-acidification of the clathrin sculpted acetylcholine transport vesicle [Homo sapiens] - Neurotransmitter uptake and Metabolism In Glial Cells - Astrocytic Glutamate-Glutamine Uptake And Metabolism - glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] [Homo sapiens] - Neuroransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell - Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity - Trafficking of AMPA receptors - Trafficking of GluR1-containing AMPA receptors [Homo sapiens] - Trafficking of GluR2-containing AMPA receptors - Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites [Homo sapiens] - Trafficking of GluR2-containing AMPA receptors to synapse [Homo sapiens] - Endocytosis of Ca impermeable AMPA receptors [Homo sapiens] - Activation of NMDA receptor upon glutamate binding and postsynaptic events - Post NMDA receptor activation events - CREB phophorylation through the activation of Ras - Raf activation [Homo sapiens] - Activation of MAPK [Homo sapiens] - RSK activation - Phosphorylation by MAPK/ERK [Homo sapiens] - CREB phosphorylation through the activation of Adenylate Cyclase - Activation of Adenylate Cyclase [Homo sapiens] - CREB phosphorylation through the activation of CaMKK - Activation of CaMKK [Homo sapiens] Biological oxidations - Phase 1 - Functionalization of compounds - Ethanol oxidation - acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] [Homo sapiens] - Phase II conjugation - Cytosolic sulfonation of small molecules - Formation of PAPS - ATP + sulfate => adenylyl sulfate (APS) + pyrophosphate [Homo sapiens] - adenylyl sulfate (APS) + ATP => PAPS + ADP [Homo sapiens] - Methylation - SAM is sythesized from methionine's reaction with ATP [Homo sapiens] - Glutathione conjugation - Glutathione synthesis - Glutamate and cysteine combine [Homo sapiens] - gamma-glutamylcysteine combines with glycine to form glutathione [Homo sapiens] Signaling by GPCR - GPCR downstream signaling - G alpha (s) signalling events - Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate [Homo sapiens] - G alpha (i) signalling events - Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate [Homo sapiens] - G alpha (z) signalling events - Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate [Homo sapiens] - G alpha (q) signalling events - Effects of PIP2 hydrolysis - DAG kinase produces phosphatidic acid from DAG [Homo sapiens] - G-protein beta:gamma signalling - G beta:gamma signalling through PI3Kgamma - G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 [Homo sapiens] DNA Replication - Synthesis of DNA - Switching of origins to a post-replicative state - CDK-mediated phosphorylation and removal of Cdc6 - Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex [Homo sapiens] - Regulation of DNA replication - Removal of licensing factors from origins - CDK-mediated phosphorylation and removal of Cdc6 - Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex [Homo sapiens] Muscle contraction - Striated Muscle Contraction - Myosin Binds ATP [Homo sapiens] - ATP Hydrolysis By Myosin [Homo sapiens] - Smooth Muscle Contraction - Myosin Binds ATP [Homo sapiens] - ATP Hydrolysis By Myosin [Homo sapiens] - Phosphorylation of Smooth Muscle Myosin Light Chains [Homo sapiens] Gene Expression - Translation - Eukaryotic Translation Initiation - Cap-dependent Translation Initiation - Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S - Cap-bound mRNA is activated by helicases [Homo sapiens] - Ribosomal scanning and start codon recognition - Ribosomal scanning [Homo sapiens] - tRNA Aminoacylation - Cytosolic tRNA aminoacylation - alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate [Homo sapiens] - arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate [Homo sapiens] - asparagine + tRNA(Asn) + ATP => Asn-tRNA(Asn) + AMP + pyrophosphate [Homo sapiens] - aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate [Homo sapiens] - cysteine + tRNA(Cys) + ATP => Cys-tRNA(Cys) + AMP + pyrophosphate [Homo sapiens] - glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate [Homo sapiens] - glutamine + tRNA(Gln) + ATP => Gln-tRNA(Gln) + AMP + pyrophosphate [Homo sapiens] - glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate [Homo sapiens] - histidine + tRNA(His) + ATP => His-tRNA(His) + AMP + pyrophosphate [Homo sapiens] - isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate [Homo sapiens] - leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate [Homo sapiens] - lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate [Homo sapiens] - methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate [Homo sapiens] - phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate [Homo sapiens] - proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate [Homo sapiens] - serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate [Homo sapiens] - threonine + tRNA(Thr) + ATP => Thr-tRNA(Thr) + AMP + pyrophosphate [Homo sapiens] - tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate [Homo sapiens] - tyrosine + tRNA(Tyr) + ATP =>Tyr-tRNA(Tyr) + AMP + pyrophosphate [Homo sapiens] - valine + tRNA(Val) + ATP => Val-tRNA(Val) + AMP + pyrophosphate [Homo sapiens] Signaling by Insulin receptor - Autophosphorylation of insulin receptor [Homo sapiens] - Insulin receptor signalling cascade - SHC-related events - SHC activation - Phosphorylation of SHC [Homo sapiens] - SHC-mediated signalling - RAF activation - Stabilisation of RAF by further phosphorylation [Homo sapiens] - MAP kinase cascade - MEK activation - RAF phosphorylates MEK - RAF1 phosphorylates MEK1 [Homo sapiens] - RAF1 phosphorylates MEK2 [Homo sapiens] - ERK activation - ERK1 activation - Inactivation of MEK1 by p34cdc2 [Homo sapiens] - MEK1 phosphorylates ERK-1 [Homo sapiens] - ERK2 activation - MEK2 phosphorylates ERK-2 [Homo sapiens] - IRS-related events - IRS activation - Phosphorylation of IRS [Homo sapiens] - IRS-mediated signalling - PI3K Cascade - PIP2 conversion to PIP3 [Homo sapiens] - PKB-mediated events - PDE3B signalling - Phosphorylation of PDE3B [Homo sapiens] - mTOR signalling - Inhibition of TSC complex formation by PKB - Phosphorylation of TSC2 by PKB [Homo sapiens] - Phosphorylation of complexed TSC2 by PKB [Homo sapiens] - mTORC1-mediated signalling - S6K1-mediated signalling - Activation of S6K1 [Homo sapiens] - S6K1 signalling - Phosphorylation of Ribosomal protein S6 by activated S6K1 [Homo sapiens] - Phosphorylation and inactivation of eEF2K by activated S6K1 [Homo sapiens] - Phosphorylation and activation of eIF4G by activated S6K1 [Homo sapiens] - Phosphorylation and activation of eIF4B by activated S6K1 [Homo sapiens] - Release of eIF4E - Phosphorylation of 4E-BP1 by activated mTORC1 [Homo sapiens] - Energy dependent regulation of mTOR by LKB1-AMPK - Regulation of AMPK activity via LKB1 - Activation of cytosolic AMPK by phosphorylation [Homo sapiens] - AMPK phosphorylates Raptor [Homo sapiens] - Regulation of Rheb GTPase activity by AMPK - Phosphorylated AMPK phosphorylates TSC2 [Homo sapiens] - Activation of PKB - Phosphorylation of AKT2 by PDK1 [Homo sapiens] - SOS-mediated signalling - RAF activation - Stabilisation of RAF by further phosphorylation [Homo sapiens] - MAP kinase cascade - MEK activation - RAF phosphorylates MEK - RAF1 phosphorylates MEK1 [Homo sapiens] - RAF1 phosphorylates MEK2 [Homo sapiens] - ERK activation - ERK1 activation - Inactivation of MEK1 by p34cdc2 [Homo sapiens] - MEK1 phosphorylates ERK-1 [Homo sapiens] - ERK2 activation - MEK2 phosphorylates ERK-2 [Homo sapiens] - Signal attenuation - SOS phosphorylation and dissociation (SHC) [Homo sapiens] - SOS phosphorylation and dissociation (IRS) [Homo sapiens] - SOS phosphorylation and dissociation (IRS, Crk) [Homo sapiens] Integration of energy metabolism - Regulation of Insulin Secretion - ADP-ATP translocase maintains a high ADP:ATP ratio in the matrix [Homo sapiens] - Closing of Inward Rectifying, ATP-sensitive Potassium Channels (KATP channels) [Homo sapiens] - Regulation of Insulin Secretion by Glucagon-like Peptide-1 - Production of Cyclic AMP by Activated Adenylyl Cyclase [Homo sapiens] - Regulation of Insulin Secretion by Acetylcholine - Phosphorylation of MARCKS by Protein kinase C, alpha type [Homo sapiens] - Glucagon signaling in metabolic regulation - PKA activation in glucagon signalling - Activated Adenylate cyclase catalyses cAMP synthesis [Homo sapiens] - PKA-mediated phosphorylation of key metabolic factors - Phosphorylation of pChREBP (Thr 666) at Ser(196) by PKA [Homo sapiens] - Phosphorylation of PF2K-Pase by PKA catalytic subunit [Homo sapiens] Signaling by EGFR - EGFR autophosphorylation [Homo sapiens] - Phosphorylation of EGFR by SRC kinase [Homo sapiens] - EGFR interacts with phospholipase C-gamma - EGFR activates PLC-gamma1 by phosphorylation [Homo sapiens] - Grb2 events in EGFR signaling - RAF activation - Stabilisation of RAF by further phosphorylation [Homo sapiens] - MAP kinase cascade - MEK activation - RAF phosphorylates MEK - RAF1 phosphorylates MEK1 [Homo sapiens] - RAF1 phosphorylates MEK2 [Homo sapiens] - ERK activation - ERK1 activation - Inactivation of MEK1 by p34cdc2 [Homo sapiens] - MEK1 phosphorylates ERK-1 [Homo sapiens] - ERK2 activation - MEK2 phosphorylates ERK-2 [Homo sapiens] - Shc events in EGFR signaling - Shc phosphorylation by phospho-EGFR:EGF [Homo sapiens] - RAF activation - Stabilisation of RAF by further phosphorylation [Homo sapiens] - MAP kinase cascade - MEK activation - RAF phosphorylates MEK - RAF1 phosphorylates MEK1 [Homo sapiens] - RAF1 phosphorylates MEK2 [Homo sapiens] - ERK activation - ERK1 activation - Inactivation of MEK1 by p34cdc2 [Homo sapiens] - MEK1 phosphorylates ERK-1 [Homo sapiens] - ERK2 activation - MEK2 phosphorylates ERK-2 [Homo sapiens] - Gab1 signalosome - PI3K converts Phosphatidylinositol-4,5-bisphosphate to Phosphatidylinositol-3,4,5-trisphosphate [Homo sapiens] - Gab1 phosphorylation by EGFR kinase [Homo sapiens] - EGFR downregulation - Phosphorylation of Cbl (EGFR:Cbl) [Homo sapiens] - Phosphorylation of Cbl (EGFR:Cbl:Grb2) [Homo sapiens] Metabolism of carbohydrates - Hexose transport - Glucose transport - GLUT1 + ATP <=> GLUT1:ATP [Homo sapiens] - GLUT1:ATP <=> GLUT1 + ATP [Homo sapiens] - alpha-D-Glucose + ATP => alpha-D-glucose 6-phosphate + ADP [Homo sapiens] - Glucose metabolism - Glycolysis - D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP [Homo sapiens] - D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP [Homo sapiens] - 1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ADP [Homo sapiens] - phosphoenolpyruvate + ADP => pyruvate + ATP [Homo sapiens] - Gluconeogenesis - ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate [Homo sapiens] - Phosphorylation of PF2K-Pase by PKA catalytic subunit [Homo sapiens] - Glycogen breakdown (glycogenolysis) - glycogen phosphorylase (PYGB) dimer b + 2 ATP => glycogen phosphorylase (PYGB) dimer a + 2 ADP [Homo sapiens] - glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP [Homo sapiens] - glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP [Homo sapiens] - Fructose catabolism - ATP + beta-D-fructose => ADP + D-fructose 1-phosphate [Homo sapiens] - ATP + D-glyceraldehyde => ADP + D-glyceraldehyde 3-phosphate [Homo sapiens] - Galactose catabolism - ATP + D-galactose => ADP + D-galactose 1-phosphate [Homo sapiens] - 5-Phosphoribose 1-diphosphate biosynthesis - D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate [Homo sapiens] Myogenesis - CDO in myogenesis - Activation of p38 alpha/beta MAPK [Homo sapiens]
Produced by events	(d)ADP + ADP <=> (d)AMP + ATP [AK1] [Homo sapiens] (d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP [AK5] [Homo sapiens] (d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP [CMPK1] [Homo sapiens] (d)GDP + ADP <=> (d)GMP + ATP [GUK1] [Homo sapiens] (d)NTP + ADP <=> (d)NDP + ATP [NME1,2,3] [Homo sapiens] 1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ADP [Homo sapiens] ADP + ADP <=> AMP + ATP [AK2] [Homo sapiens] ADP-ATP translocase maintains a high ADP:ATP ratio in the matrix [Homo sapiens] dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK] [Homo sapiens] GLUT1:ATP <=> GLUT1 + ATP [Homo sapiens] phosphoenolpyruvate + ADP => pyruvate + ATP [Homo sapiens]
Consumed by events	(2'-deoxy)adenosine + ATP => (d)AMP + ADP [ADK] [Homo sapiens] (2'-deoxy)cytidine + ATP => (d)CMP + ADP [DCK] [Homo sapiens] (d)AMP + ATP <=> (d)ADP + ADP [AK1] [Homo sapiens] (d)AMP or (d)CMP + ATP <=> (d)ADP or (d)CDP + ADP [AK5] [Homo sapiens] (d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP [CMPK1] [Homo sapiens] (d)GMP + ATP <=> (d)GDP + ADP [GUK1] [Homo sapiens] (d)NDP + ATP <=> (d)NTP + ADP [NME1,2,3] [Homo sapiens] 3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) [Homo sapiens] 3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) [Homo sapiens] 5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi [Homo sapiens] ABCA1-mediated transport of intracellular cholesterol to the cell surface [Homo sapiens] ABCA1-mediated transport of intracellular phospholipid to the cell surface [Homo sapiens] ABCG1-mediated transport of intracellular cholesterol to the cell surface [Homo sapiens] ABCG5:ABCG8-mediated export of cholesterol and phytosterols [Homo sapiens] acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] [Homo sapiens] acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate [Homo sapiens] Activated Adenylate cyclase catalyses cAMP synthesis [Homo sapiens] activated human TAK1 phosphorylates MKK3/MKK6 [Homo sapiens] Activated TAK1 mediates phosphorylation of the IKK Complex [Homo sapiens] Activated TAK1 phosphorylates MKK4/MKK7 [Homo sapiens] Activated type I receptor phosphorylates R-SMAD directly [Homo sapiens] Activated type I receptor phosphorylates R-Smad1/5/8 directly [Homo sapiens] Activation of Adenylate Cyclase [Homo sapiens] Activation of CaMKK [Homo sapiens] Activation of caspase-3 [Homo sapiens] Activation of cytosolic AMPK by phosphorylation [Homo sapiens] Activation of IKK complex [Homo sapiens] Activation of Lck [Homo sapiens] Activation of MAPK [Homo sapiens] Activation of NF-kB complex [Homo sapiens] Activation of p38 alpha/beta MAPK [Homo sapiens] Activation of recruited TAK1 within the complex viral dsRNA:TLR3:TRIF:pUb-TRAF6:TAB1:Ub-TAB2:Ub-TAB3: TAK1 [Homo sapiens] Activation of S6K1 [Homo sapiens] Activation of Src [Homo sapiens] Activation of TAK1-TAB2 complex [Homo sapiens] Activation of Vav1 [Homo sapiens] Activation of ZAP-70 [Homo sapiens] Adenylate cyclase converts ATP into cyclic AMP [Homo sapiens] Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate [Homo sapiens] Adenylate cyclase produces cAMP [Homo sapiens] Adenylation of phosphopantetheine [Homo sapiens] adenylyl sulfate (APS) + ATP => PAPS + ADP [Homo sapiens] ADP is exchanged for ATP in the (ADP:CCT/TriC):tubulin complex [Homo sapiens] AKT interacts and phosphorylates Cot [Homo sapiens] AKT phosphorylates TSC2, inhibiting it [Homo sapiens] AKT phosphorylates BAD [Homo sapiens] AKT phosphorylates caspase-9 [Homo sapiens] Akt phosphorylates eNOS [Homo sapiens] AKT phosphorylates GSK3 [Homo sapiens] AKT phosphorylates IKKalpha [Homo sapiens] AKT phosphorylates MDM2 [Homo sapiens] AKT phosphorylates p21Cip1 and p27Kip1 [Homo sapiens] AKT phosphorylates PRAS40 [Homo sapiens] Akt:pCot phosphorylates NIK [Homo sapiens] alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate [Homo sapiens] alpha-D-Glucose + ATP => alpha-D-glucose 6-phosphate + ADP [Homo sapiens] Amidation of deamino-NAD+ to NAD+ [Homo sapiens] AMP + ATP <=> ADP + ADP [AK2] [Homo sapiens] AMPK phosphorylates Raptor [Homo sapiens] arachidonate + CoASH + ATP => arachidonoyl-CoA + AMP + pyrophosphate + H2O [ACSL4] [Homo sapiens] arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate [Homo sapiens] ARMS is phosphorylated by active TrkA receptor [Homo sapiens] asparagine + tRNA(Asn) + ATP => Asn-tRNA(Asn) + AMP + pyrophosphate [Homo sapiens] aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] [Homo sapiens] aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate [Homo sapiens] ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate [Homo sapiens] ATP + aspartate + citrulline <=> argininosuccinate + AMP + pyrophosphate [Homo sapiens] ATP + beta-D-fructose => ADP + D-fructose 1-phosphate [Homo sapiens] ATP + D-galactose => ADP + D-galactose 1-phosphate [Homo sapiens] ATP + D-glyceraldehyde => ADP + D-glyceraldehyde 3-phosphate [Homo sapiens] ATP + sulfate => adenylyl sulfate (APS) + pyrophosphate [Homo sapiens] Auto-phosphorylation of FADK1 at Y397 [Homo sapiens] Autocatalytic phosphorylation of FGFR1b [Homo sapiens] Autocatalytic phosphorylation of FGFR1c [Homo sapiens] Autocatalytic phosphorylation of FGFR2b [Homo sapiens] Autocatalytic phosphorylation of FGFR2c [Homo sapiens] Autocatalytic phosphorylation of FGFR3b [Homo sapiens] Autocatalytic phosphorylation of FGFR3c [Homo sapiens] Autocatalytic phosphorylation of FGFR4 [Homo sapiens] Autocatalytic phosphorylation of Klotho-bound FGFR1c [Homo sapiens] Autophosphorylation of c-src [Homo sapiens] Autophosphorylation of insulin receptor [Homo sapiens] Autophosphorylation of IRE1 dimer [Homo sapiens] Autophosphorylation of NCAM1 bound Fyn [Homo sapiens] Autophosphorylation of NCAM1 bound Fyn [Mus musculus] Autophosphorylation of PAK [Homo sapiens] Autophosphorylation of PAK-2p34 in the activation loop [Homo sapiens] Autophosphorylation of PDGF alpha receptors [Homo sapiens] Autophosphorylation of PDGF alpha/beta receptors [Homo sapiens] Autophosphorylation of PDGF beta receptors [Homo sapiens] Binding and activation of MAP Kinase [Homo sapiens] CAIR + Aspartate + ATP => SAICAR + ADP + Pi [Homo sapiens] Cap-bound mRNA is activated by helicases [Homo sapiens] CD28 bound PI3K phosphorylates PIP2 to PIP3 [Homo sapiens] CERT + ATP => monophospho-CERT + ADP [Homo sapiens] Change of PKC theta conformation [Homo sapiens] Cleavage of Procaspase-7 by the apoptosome [Homo sapiens] Cleavage of Procaspase-3 by the apoptosome [Homo sapiens] Closing of Inward Rectifying, ATP-sensitive Potassium Channels (KATP channels) [Homo sapiens] Condensation of phosphopantothenate with cysteine [Homo sapiens] Conversion of cytosolic 5-methyltetrahydrofolate (5-methylTHF) to 5-methylTHF-polyglutamate [Homo sapiens] Conversion of cytosolic THF to THF-polyglutamate [Homo sapiens] Conversion of Glycerol to Glycerol-3-phosphate [Homo sapiens] creatine + ATP => phosphocreatine + ADP [CK octamer] [Homo sapiens] creatine + ATP => phosphocreatine + ADP [CKB,CKM] [Homo sapiens] cysteine + tRNA(Cys) + ATP => Cys-tRNA(Cys) + AMP + pyrophosphate [Homo sapiens] cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] [Homo sapiens] cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] [Homo sapiens] Cytochrome C:Apaf-1 binds Procaspase-9 [Homo sapiens] Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex [Homo sapiens] Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) [Homo sapiens] D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP [Homo sapiens] D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP [Homo sapiens] D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate [Homo sapiens] DAG kinase produces phosphatidic acid from DAG [Homo sapiens] DAG stimulates protein kinase C-delta [Homo sapiens] deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP [DCK] [Homo sapiens] DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) [Homo sapiens] DHCA is conjugated with Coenzyme A (SLC27A5 BACS) [Homo sapiens] dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] [Homo sapiens] EGFR activates PLC-gamma1 by phosphorylation [Homo sapiens] EGFR autophosphorylation [Homo sapiens] Endocytosis of Ca impermeable AMPA receptors [Homo sapiens] ERK5 is activated [Homo sapiens] Exchange of ADP for ATP in CCT/TriC:actin complex [Homo sapiens] FGAM + ATP => AIR + ADP + Pi [Homo sapiens] FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi [Homo sapiens] First phosphorylation of IRAK1 by IRAK4 bound to activated TLR [Homo sapiens] FMN is futher phosphorylated to FAD [Homo sapiens] Formation of Cyclin D:Cdk4/6 complexes [Homo sapiens] Formation of Malonyl-CoA from Acetyl-CoA (muscle) [Homo sapiens] Fyn/Lyn-mediated phosphorylation of FcR1 gamma [Homo sapiens] G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 [Homo sapiens] Gab1 phosphorylation by EGFR kinase [Homo sapiens] gamma-glutamylcysteine combines with glycine to form glutathione [Homo sapiens] Generation of Cytoplasmic Acetyl CoA from Citrate [Homo sapiens] GLUT1 + ATP <=> GLUT1:ATP [Homo sapiens] glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] [Homo sapiens] glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate [Homo sapiens] Glutamate and cysteine combine [Homo sapiens] glutamine + tRNA(Gln) + ATP => Gln-tRNA(Gln) + AMP + pyrophosphate [Homo sapiens] glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate [Homo sapiens] glycogen phosphorylase (PYGB) dimer b + 2 ATP => glycogen phosphorylase (PYGB) dimer a + 2 ADP [Homo sapiens] glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP [Homo sapiens] glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP [Homo sapiens] GTP-bound RAC contributes to JNK activation [Homo sapiens] histidine + tRNA(His) + ATP => His-tRNA(His) + AMP + pyrophosphate [Homo sapiens] hormone-sensitive lipase (HSL) + 2 ATP -> phosphorylated HSL + 2 ADP [Homo sapiens] IKKbeta is activated [Homo sapiens] IKKbeta phosphorylates IkB causing NF-kB to dissociate [Homo sapiens] Inactivation of Lck by Csk [Homo sapiens] Inactivation of MEK1 by p34cdc2 [Homo sapiens] Interaction of PAK1 with Rac1-GTP [Homo sapiens] IRAK is activated [Homo sapiens] IRAK1 and 4 can phosphorylate Pellino-1 and 2. [Homo sapiens] IRAK4 is activated by autophosphorylation [Homo sapiens] IRAK4 phosphorylates IRAK1 [Homo sapiens] IRAK4-activated IRAK1 autophosphorylates [Homo sapiens] isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate [Homo sapiens] JNK phosphorylates BIM, BAD and other targets [Homo sapiens] L-glutamine + 2 ATP + HCO3- + H2O => carbamoyl phosphate + L-glutamate + 2 ADP + orthophosphate [Homo sapiens] leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate [Homo sapiens] LIM kinase phosphorylation by ROCK [Homo sapiens] lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate [Homo sapiens] MAP kinase activates MAPKAPK2, MAPKAPK3 and MSK1 [Homo sapiens] MEK1 phosphorylates ERK-1 [Homo sapiens] MEK2 phosphorylates ERK-2 [Homo sapiens] methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate [Homo sapiens] Mevalonate is phosphorylated to mevalonate-5-phosphate [Homo sapiens] Mevalonate-5-phosphate is further phosphorylated. [Homo sapiens] Mevalonate-5-pyrophosphate is decarboxylated [Homo sapiens] monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP [Homo sapiens] Multiple IRAK1 autophosphorylation steps [Homo sapiens] Myosin Binds ATP [Homo sapiens] Myosin Binds ATP [Homo sapiens] Myosin regulatory light chain phosphorylation by ROCK [Homo sapiens] Myt-1 mediated phosphorylation of Cyclin A:Cdc2 [Homo sapiens] Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes [Homo sapiens] NAD+ is phosphorylated to NADP+ [Homo sapiens] Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT2] [Homo sapiens] Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT3] [Homo sapiens] NRAGE activates JNK [Homo sapiens] NRIF and TRAF6 may activate JNK [Homo sapiens] P2Y purinoceptor 1 activates MAP kinase p38 alpha [Homo sapiens] palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL1] [Homo sapiens] palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL3] [Homo sapiens] palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL5] [Homo sapiens] palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL6] [Homo sapiens] pAMPK inactivates ACC2 inhibiting malonyl-CoA synthesis [Homo sapiens] Pantothenate is phosphorylated [PANK1;3;4] [Homo sapiens] Pantothenate is phosphorylated [PANK2] [Homo sapiens] Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197 [Homo sapiens] PDK1 activates PKC zeta [Homo sapiens] PDK1 phosphorylates AKT at T308 [Homo sapiens] perilipin + 2 ATP -> phosphorylated perilipin + 2 ADP [Homo sapiens] phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate [Homo sapiens] Phoshorylation of PECAM-1 by Fyn or Lyn or c-Src [Homo sapiens] Phospho-IKK Complex phosphorylates IkB within the IkB:NFkB Complex [Homo sapiens] Phosphoryation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3 [Homo sapiens] Phosphorylated AMPK phosphorylates TSC2 [Homo sapiens] Phosphorylation and activation of eIF4B by activated S6K1 [Homo sapiens] Phosphorylation and activation of eIF4G by activated S6K1 [Homo sapiens] Phosphorylation and activation of Ezrin [Homo sapiens] Phosphorylation and inactivation of eEF2K by activated S6K1 [Homo sapiens] Phosphorylation and Release of IRF3 or IRF7 [Homo sapiens] Phosphorylation by MAPK/ERK [Homo sapiens] Phosphorylation of 4E-BP1 by activated mTORC1 [Homo sapiens] Phosphorylation of AKT2 by PDK1 [Homo sapiens] Phosphorylation of APC component of the destruction complex [Homo sapiens] Phosphorylation of Bcl10 [Homo sapiens] Phosphorylation of beta-catenin at Ser45 by CK1 alpha [Homo sapiens] Phosphorylation of CARMA1 [Homo sapiens] Phosphorylation of Cbl (EGFR:Cbl) [Homo sapiens] Phosphorylation of Cbl (EGFR:Cbl:Grb2) [Homo sapiens] Phosphorylation of CD28 [Homo sapiens] Phosphorylation of cofilin by LIMK-1 [Homo sapiens] Phosphorylation of cofilin by LIMK-1 [Mus musculus] Phosphorylation of complexed TSC2 by PKB [Homo sapiens] Phosphorylation of cPLA2 by MAPK p38 alpha [Homo sapiens] Phosphorylation of CRMPs by Cdk5 [Homo sapiens] Phosphorylation of CRMPs by GSK3beta [Homo sapiens] Phosphorylation of CTLA-4 [Homo sapiens] Phosphorylation of Cx43 by c-src [Homo sapiens] Phosphorylation of Cyclin B1 in the CRS domain [Homo sapiens] Phosphorylation of DCC by Fyn [Homo sapiens] Phosphorylation of dephospho-CoA to produce CoA [Homo sapiens] Phosphorylation of EGFR by SRC kinase [Homo sapiens] Phosphorylation of eIF2-alpha by PERK [Homo sapiens] Phosphorylation of FADK1 [Homo sapiens] Phosphorylation of FAK by Src kinase [Homo sapiens] Phosphorylation of FRS2-alpha by activated FGFR [Homo sapiens] Phosphorylation of human JNKs by activated MKK4/MKK7 [Homo sapiens] Phosphorylation of IRS [Homo sapiens] Phosphorylation of ITAM motifs in CD3 complexes [Homo sapiens] Phosphorylation of L1 by CK-II [Homo sapiens] Phosphorylation of L1 by EPHB2 [Homo sapiens] Phosphorylation of L1 by ERK [Homo sapiens] Phosphorylation of L1 by p90rsk [Homo sapiens] Phosphorylation of L1 by p90rsk [Homo sapiens] Phosphorylation of L1 by SRC [Homo sapiens] Phosphorylation of LIMK-1 by PAK [Homo sapiens] Phosphorylation of MARCKS by Protein kinase C, alpha type [Homo sapiens] Phosphorylation of Neurofascin [Homo sapiens] Phosphorylation of p130Cas by Src-FAK complex [Homo sapiens] Phosphorylation of pChREBP (Thr 666) at Ser(196) by PKA [Homo sapiens] Phosphorylation of PD-1 [Homo sapiens] Phosphorylation of PDE3B [Homo sapiens] Phosphorylation of PF2K-Pase by PKA catalytic subunit [Homo sapiens] Phosphorylation of pFADK1 by SRC [Homo sapiens] Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 [Homo sapiens] Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 [Homo sapiens] Phosphorylation of PKC theta [Homo sapiens] Phosphorylation of Platelet Sec-1 [Homo sapiens] Phosphorylation of PLC-gamma1 [Homo sapiens] Phosphorylation of PLCgamma by Netrin-1 [Homo sapiens] Phosphorylation of Plexin-A [Homo sapiens] Phosphorylation of proteins involved in G2/M transition by active Cyclin B2:Cdc2 complexes [Homo sapiens] Phosphorylation of Ribosomal protein S6 by activated S6K1 [Homo sapiens] Phosphorylation of Rob1 by Abl kinase [Homo sapiens] Phosphorylation of SHC [Homo sapiens] Phosphorylation of SLP-76 [Homo sapiens] Phosphorylation of Smooth Muscle Myosin Light Chains [Homo sapiens] Phosphorylation of Syntaxin-4 [Homo sapiens] Phosphorylation of TBSMs in LAT [Homo sapiens] Phosphorylation of TSC2 by PKB [Homo sapiens] Phosphorylation of Unc5C [Homo sapiens] Phosphorylation of VAV2 [Homo sapiens] Phosphorylation of Y1229 in L1 [Homo sapiens] Phosphorylation of ZAP-70 by Lck [Homo sapiens] PI3K alpha, beta, gamma convert PIP2 to PIP3 [Homo sapiens] PI3K catalyses the phosphorylation of PIP2 to PIP3 [Homo sapiens] PI3K converts Phosphatidylinositol-4,5-bisphosphate to Phosphatidylinositol-3,4,5-trisphosphate [Homo sapiens] PI3K phosphorylates PIP2 to PIP3 [Homo sapiens] PI3K produces PIP3 and other phosphatidyl inositides [Homo sapiens] PIP2 conversion to PIP3 [Homo sapiens] PKA phosphorylates DARPP-32 on Thr34 [Homo sapiens] PKA phosphorylates PDE4B [Homo sapiens] PKC phosphorylates GRK2 [Homo sapiens] PLC gamma phosphorylation by FGFR [Homo sapiens] Plk1-mediated phosphorylation of Nlp [Homo sapiens] PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP [Homo sapiens] Production of Cyclic AMP by Activated Adenylyl Cyclase [Homo sapiens] proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate [Homo sapiens] Raf activation [Homo sapiens] RAF1 phosphorylates MEK1 [Homo sapiens] RAF1 phosphorylates MEK2 [Homo sapiens] Re-acidification of clathrin sculpted monoamine tranport vesicle lumen [Homo sapiens] Re-acidification of the clathrin sculpted acetylcholine transport vesicle [Homo sapiens] Recruitment and activation of Cdk5 [Homo sapiens] Recruitment and activation of Cdk5 [Gallus gallus] Recruitment of FAK to NCAM1:Fyn in lipid rafts [Homo sapiens] Recruitment of human TBK1/IKK epsilon to the Viral dsRNA:TLR3:TRIF Complex followed by their activation [Homo sapiens] Riboflavin is phosphorylated to FMN [Homo sapiens] Ribosomal scanning [Homo sapiens] RIP1 phosphorylates IKKs [Homo sapiens] ROCK1 activates LIM kinase 2 (rat) [Homo sapiens] SAM is sythesized from methionine's reaction with ATP [Homo sapiens] Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR [Homo sapiens] SEMA4D interacts with Plexin-B1:ErbB2 [Homo sapiens] SEMA4D interacts with Plexin-B1:Met [Homo sapiens] serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate [Homo sapiens] SHC becomes phosphorylated [Homo sapiens] Shc phosphorylation by phospho-EGFR:EGF [Homo sapiens] SHP2 is phosphorylated by activated FGFR [Homo sapiens] SOS phosphorylation and dissociation (IRS) [Homo sapiens] SOS phosphorylation and dissociation (IRS, Crk) [Homo sapiens] SOS phosphorylation and dissociation (SHC) [Homo sapiens] sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP [Homo sapiens] sphingosine +ATP => sphingosine 1-phosphate + ADP [Homo sapiens] Stabilisation of RAF by further phosphorylation [Homo sapiens] STAT3 activation [Homo sapiens] Syk activation leads to SLP-76 activation [Homo sapiens] TAK1 phosphorylates MKK6 [Homo sapiens] TBK1-mediated phosphorylation of IRF-3 [Homo sapiens] TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) [Homo sapiens] TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) [Homo sapiens] THCA is conjugated with Coenzyme A (SLC27A2 VLCS) [Homo sapiens] THCA is conjugated with Coenzyme A (SLC27A5 BACS) [Homo sapiens] The IKKB complex phosphorylates NFkB p105 [Homo sapiens] THF polyglutamate + formate + ATP => 10-formylTHF polyglutamate + ADP + orthophosphate [Homo sapiens] Thiamin is pyrophosphorylated [Homo sapiens] threonine + tRNA(Thr) + ATP => Thr-tRNA(Thr) + AMP + pyrophosphate [Homo sapiens] thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1] [Homo sapiens] TORC2 (mTOR) phosphorylates AKT at S473 [Homo sapiens] TPL2 phosphorylates MEK1, SEK1 [Homo sapiens] Trafficking of GluR1-containing AMPA receptors [Homo sapiens] Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites [Homo sapiens] Trafficking of GluR2-containing AMPA receptors to synapse [Homo sapiens] trans-Golgi Network Derived Lysosomal Vesicle Uncoating [Homo sapiens] trans-Golgi Network Derived Vesicle Uncoating [Homo sapiens] Trans-phosphorylation of Tie2 [Homo sapiens] Transphosphorylation of pLIMK1 [Homo sapiens] Transport (efflux) of bile salts by ABCB11 (bile salt export pump) [Homo sapiens] Transport (efflux) of bile salts by ABCC3 (MRP3) [Homo sapiens] TRKA phosphorylates IRS [Homo sapiens] TrkA phosphorylates PLCG1 [Homo sapiens] TrkA receptor autophosphorylates [Homo sapiens] tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate [Homo sapiens] Type II receptor phosphorylates type I receptor [Homo sapiens] Type II receptor phosphorylates type I receptor [Homo sapiens] tyrosine + tRNA(Tyr) + ATP =>Tyr-tRNA(Tyr) + AMP + pyrophosphate [Homo sapiens] Tyrosine phosphorylation of CRMPs by Fes [Homo sapiens] UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] [Homo sapiens] UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] [Homo sapiens] valine + tRNA(Val) + ATP => Val-tRNA(Val) + AMP + pyrophosphate [Homo sapiens] XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate [Homo sapiens]
Other forms of this molecule	ATP [nucleoplasm] ATP [mitochondrial matrix] ATP [extracellular region] ATP [platelet dense granule lumen] ATP [plasma membrane] ATP [endosome] ATP [peroxisomal membrane] ATP [peroxisomal matrix] ATP [intracellular]

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