Reactome: de Bono, B

Details

Author of summation(s)
Surname	de Bono
First name	Bernard
Initials	B
Affiliation	EBI
A hallmark of human NK cells is the expression of HLA class ... A number of MHC Class I molecules a known bind differentiall... A number of receptors and cell adhesion molecules play a key... Activated FRS2-alpha contains four binding sites for the ada... Activation of phospholipase C enzymes results in the generat... After cleavage of C5, C5b undergoes conformational changes a... After interaction with its ligand HLA-E, which is expressed ... Although JAM-C is better known for its interaction with MAC-... Apart from its well-established interaction with VLA-4, JAM-... At the receptor, IRAK1 associates with MyD88, and phosphoryl... C1 activation requires interaction with two separate Fc doma... C1 is a calcium-dependent complex of C1q, R and S in the mol... C1, the first component of complement is a complex containin... C2 is cleaved into the large C2a and the small C2b fragment.... C3b on a surface binds Factor B from solution to form a comp... C4 alpha chain has a thioester bond between Cys 1010 and Gln... C4 is cleaved into the small C4a and the large C4b fragment ... C4b and C2a form a complex termed the classical pathway C3 c... CD160 is a GPI-anchored lymphocyte surface receptor in which... CD177 is a 58- to 64-kDa glycosylphosphatidylinositol-anchor... CD19 is a lymphocyte cell surface molecule that functions as... CD2, CD48, CD84, CD244 and CD58 have a similar extracellular... CD40 is a member of the Tumour Necrosis Factor receptor fami... CD84 is a homophilic receptor expressed on T cells, B cells,... Circulates in blood as a disulfide-linked trimer of an alpha... Complement activation is due to a cascade of proteolytic ste... Complement Factor 3(H2O) (C3(H2O)), the product of the spont... CpG DNA is an unusual Pathogen-Associated Molecular Pattern ... Dissociation from the activated receptor quickly follows pho... Dominant mutations in the fibroblast growth factor receptor ... eIF4B is a physiologically relevant target of S6K1. Once pho... Endosomal recognition of influenza genomic RNA and imidazoqu... Extracellular MBL oligomer complexed with MASP2 binds to a r... Factor D, a constitutively active serine protease found in t... Factor D, a constitutively active serine protease found in t... FGF23 is a unique member of the fibroblast growth factor (FG... FGFR3 is a receptor tyrosine kinase of the FGF receptor fami... FGFR4 is expressed mainly in mature skeletal muscle, and dis... FGFs bind and activate alternatively spliced forms of four t... First, IRAK-1 is phosphorylated at Thr209. This results in a... Fragments of extracelllar flagellin bind the TLR5 homodimer. FRS2 is an adapter protein that links FGFR receptors to down... Gab1 binds constitutively to the C-terminal SH3 domain of Gr... Grb2 bound to tyrosine phosphorylated FRS2 forms a ternary c... Hemostasis is a physiological response that culminates in th... Hyperphosphorylated IRAK-1 leaves the receptor complex and i... Hyperphosphorylation of this region leads to dissociation of... In the case of FGFR1, autophosphorylation on Tyr766 in the c... In this irreversible reaction, the activated C1r subunit of ... In this reaction, FGF receptor in the plasma membrane binds ... In this reaction, the MASP2 serine protease moiety of an MBL... In view of the highly variable nature of T-cell receptors, t... Initiation is the first step in the formation of the platele... Integrin-associated protein (IAP or CD47) is a receptor for ... Integrins play a central role in mediating lymphocyte adhe... IRAK-4 is the mammalian homolog of Drosophila melanogaster P... JAM members, such as JAML, bind coxsackie and adenovirus re... JAM-A is the most widely expressed member of the family, and... JAM-A plays a key role in leukocyte transmigration and infla... JAM-B and -C bind each other and are strongly expressed by e... JAM-C has been detected in epithelial-cell desmosomes. JAM-C... L-selectin plays a major role in leukocyte traffic through l... LBP delivers lipid A from bacteria (or bacterial membrane fr... Leukocyte extravasation is a rigorously controlled process t... Leukocyte immunoglobulin (Ig)-like receptors [LILRs, also kn... Linked by disulphide bond between positions 559 and 816. Lipopolysaccharide-binding protein (LBP) is a 65-kDa plasma ... Little is known about TLR10 ligands. It has been established... Mannose-binding lectin (MBL), a Ca-dependent (C-type) lectin... Membrane-bound FRS2 interacts with FGFR as a first step to p... MerTK appears to be required for ingestion of apoptotic cell... Most cells of the immune system express receptors for the Fc... mTOR forms a functional protein complex with at least two pr... Mucosal addressin cell adhesion molecule (MAdCAM-1) is prese... MyD88 binds to both IRAK (IL-1 receptor-associated kinase) a... NK cells express adhesion molecules that allow interaction w... NKG2D is an activating immunoreceptor. By engaging NKG2D, Hl... Once phosphorylated, S6K1-P phosphorylates and activates rib... Phospholipase C-gamma (PLC-gamma) is a substrate of the fibr... Phosphorylation of eEF2 kinase by S6K1-P results in decrease... Phosphorylation of TSC2 by PKB disrupts TSC1/TSC2 heterodime... PKB and PDK1 are activated via membrane-bound PIP3. Activate... Platelet activation begins with the initial binding of adhes... Properdin binds and stabilizes C3b:Bb complexes. It is found... PSGL-1 is expressed as a homodimer of two 120-kDa subunits t... Raptor recruits mTOR to non-phosphorylated 4E-BP1 bound to e... Recruitment of monocytic cells to the vessel wall by platele... Rheb is a GTP binding protein that exhibits GTPase activity.... RNA can serve as a danger signal, both in its double-strande... S6K1 contains a TOS motif. mTORC1 requires an intact TOS mot... Second, Thr387 in the activation loop is phosphorylated, lea... Several key IgSF cell adhesion molecules engage integrin and... SHP2 possesses two tandemly arranged SH2 domains in its N-te... Signaling via FGFRs is mediated via direct recruitment of si... Synthetic oligodeoxynucleotides (ODN) expressing non-methyla... T cells distinguish foreign material from self through prese... TANK-binding kinase 1 (TBK1) plays a crucial role in the ind... Tenacious binding of free fibronectin to cells leads to enha... The 22 members of the fibroblast growth factor (FGF) family ... The 3 pathways of complement activation converge on the clea... The ability of growth factors to protect from apoptosis is p... The complex of C3b:Factor Bb, stabilized on a cell surface b... The crystal structure of the human CD2-CD58 complex also sho... The Factor Bb component of the C3(H2O):Factor Bb catalyzes t... The first known downstream component of TLR4 signalling is t... The interferon regulatory factors (IRF) consist of a growing... The intrinsic protein tyrosine kinase activity of activated ... The lectin-like NK cell receptor KLRG1 binds to cadherins on... The lectin-like oxidized low density lipoprotein receptor- 1... The ligand to the TLR10 dimer is as yet unknown. The MyD88-independent TRAM-TRIF signalling route activates N... The phospho-tyrosine positions for FRS2-beta were inferred b... The presence of CEACAM dimers was shown to lead to an increa... The proteins participating in alternative pathway activation... The role of SHP2 phosphorylation in FGFR signaling is as yet... The same complexes as for C3 activation are employed for the... The tethering of platelets to the site of vascular injury is... The thioester linkage between cysteine residue 1010 and glut... The Toll-like receptor 4 (TLR4) is a membrane-spanning prote... The triggering receptor expressed on myeloid cells 1 (TREM-1... The two MASP2 fragments are linked via a disulphide bond bet... The vertebrate fibroblast growth factor receptor 1 (FGFR1) i... Third, IRAK-1 autophosphorylates several times in the prolin... This pathway depicts the binding of an experimentally-verifi... This pathway depicts the binding of an experimentally-verifi... This pathway depicts the binding of an experimentally-verifi... This pathway depicts the binding of an experimentally-verifi... This pathway depicts the binding of an experimentally-verifi... This pathway depicts the binding of an experimentally-verifi... Three tyrosine residues have been identified as sites of rec... TLR's TIR intracellular domain binds to a homologous domain ... TLR1 is expressed by monocytes. TLR1 and TLR2 cotranslationa... TLR2 and TLR4 recognize different bacterial cell wall compon... TLR2 is involved in recognition of peptidoglycan from gram-p... TLR5 is the receptor for flagellin, the protein that forms b... TLR9 signaling has the uncommon property of triggering PI3K-... Toll-like Receptor 4 is a Microbe Associated Molecular Patte... TRAF6 binds to MAPK kinase kinases (MEKK1), and the adapter ... TRIF mediates the MyD88-independent pathway from TLR4. TRIF-related adapter molecule (TRAM, also called TIRP or TIC... Two principal mechanisms limit blood loss after vascular inj... Tyrosine-phosphorylated FRS2 functions as a site for coordin... UniProt identifiers for both variable and constant portions ... While not ubiquitously distributed, CD200 is expressed on a ...
Author of entries
'Activated FGFR complexed with phosphorylated FRS2, GRB2 and CBL [plasma membrane]' negatively regulates 'FGFR1 binds to Klotho-bound FGF23' 'Activated FGFR complexed with phosphorylated FRS2, GRB2 and CBL [plasma membrane]' negatively regulates 'FGFR1b binds to FGF or CAM ligands' 'Activated FGFR complexed with phosphorylated FRS2, GRB2 and CBL [plasma membrane]' negatively regulates 'FGFR1c binds to FGF' 'Activated FGFR complexed with phosphorylated FRS2, GRB2 and CBL [plasma membrane]' negatively regulates 'FGFR2b binds to FGF or CAM ligands' 'Activated FGFR complexed with phosphorylated FRS2, GRB2 and CBL [plasma membrane]' negatively regulates 'FGFR2c binds to FGF' 'Activated FGFR complexed with phosphorylated FRS2, GRB2 and CBL [plasma membrane]' negatively regulates 'FGFR3b binds to FGF' 'Activated FGFR complexed with phosphorylated FRS2, GRB2 and CBL [plasma membrane]' negatively regulates 'FGFR3c binds to FGF' 'Activated FGFR complexed with phosphorylated FRS2, GRB2 and CBL [plasma membrane]' negatively regulates 'FGFR4 binds to FGF' 'ECSIT [cytosol]' is required for 'IRAK1-P(n):TRAF6 binds MEKK1' 'EEA1 homodimer [endosome membrane]' positively regulates 'Engulfed CpG DNA binds to endosomal TLR9' 'Heparan Sulphate [extracellular region]' positively regulates 'Basigin binds CyPA' 'Heterdimerization of CEACAMs' positively regulates 'Integrin alpha V beta 1 binds fibronectin' 'HSPG [extracellular region]' is required for 'FGFR1 binds to Klotho-bound FGF23' 'HSPG [extracellular region]' is required for 'FGFR1b binds to FGF or CAM ligands' 'HSPG [extracellular region]' is required for 'FGFR1c binds to FGF' 'HSPG [extracellular region]' is required for 'FGFR2b binds to FGF or CAM ligands' 'HSPG [extracellular region]' is required for 'FGFR2c binds to FGF' 'HSPG [extracellular region]' is required for 'FGFR3b binds to FGF' 'HSPG [extracellular region]' is required for 'FGFR3c binds to FGF' 'HSPG [extracellular region]' is required for 'FGFR4 binds to FGF' 'Inhibition of TSC complex formation by PKB' positively regulates 'GTP loading by Rheb' 'IRAK-M [cytosol]' negatively regulates 'Dissociation of IRAK1-P(n) from TLR4' 'JAM-B binds JAM-C' positively regulates 'VLA-4 binds JAM-B' 'Leucine-rich repeats and immunoglobulin-like domains protein 1 precursor [plasma membrane]' negatively regulates 'EGFR binds EGF ligand' 'Platelet Factor 4 [extracellular region]' positively regulates 'protein C -> activated protein C + protein C heavy chain activation peptide' 'Rab5 [endosome membrane]' is required for 'Rab5-mediated recruitment of class III PI3K to TLR9' 'RP105:MD1' negatively regulates 'Transfer of LPS onto TLR4 from CD14' 'SIGRR [plasma membrane]' negatively regulates 'MyD88 and Mal combine with the activated TLR receptor in human' 'TRIF:TRAM:activated TLR4 [plasma membrane]' is required for 'TBK1-mediated phosphorylation of IRF-3' /figures/complement_overview_rgb_small.jpg /figures/fgfr_signaling.png /figures/GPIIbII3inside_out.png /figures/GPIIbII3Integrin-MAPK.png /figures/GPIIbII3Integrin-MAPK.png /figures/hm_plt_activation.jpg /figures/hm_plt_adhesion.jpg /figures/hm_plt_response_to_ca.jpg /figures/hm_plt_top.jpg /figures/immune_synapse_figure_1.jpg /figures/integrin_signaling.png /figures/LPS.jpg /figures/mono-plt-endo.jpg 1,2-Diacylglycerol [plasma membrane] C C 1D-myo-Inositol 1,4,5-trisphosphate [cytosol] C C P 1D-myo-Inositol 1,4,5-trisphosphate [platelet dense tubular network membrane] C C P 3',5'-cyclic-nucleotide phosphodiesterase activity of Phosphorylated PDE3B [cytosol] 4E-BP1-P [cytosol] U K E G B C d O R H U R P D Activated C1R [extracellular region] Activated C1S [extracellular region] Activated C1S:activated C1R tetramer [extracellular region] Activated conventional protein kinase C [plasma membrane] Activated FGFR [plasma membrane] Activated FGFR binds PI3K [Homo sapiens] Activated FGFR binds PLC gamma [Homo sapiens] Activated FGFR bound to activated PLC gamma [plasma membrane] Activated FGFR bound to PI3K [plasma membrane] Activated FGFR bound to PLC gamma [plasma membrane] Activated FGFR complexed with FRS2 [plasma membrane] Activated FGFR complexed with phosphorylated FRS2, GRB2 and CBL [plasma membrane] Activated FGFR-alpha:p-FRS2 bind to SHP2 [Homo sapiens] Activated FGFR1b homodimer bound to FGF [plasma membrane] Activated FGFR1c homodimer bound to FGF [plasma membrane] Activated FGFR2b long homodimer bound to FGF [plasma membrane] Activated FGFR2c long homodimer bound to FGF [plasma membrane] Activated FGFR3b homodimer [plasma membrane] Activated FGFR3b homodimer bound to FGF [plasma membrane] Activated FGFR3c homodimer bound to FGF [plasma membrane] Activated FGFR4 homodimer [plasma membrane] Activated FGFR:p-FRS2-alpa:SHP2 [plasma membrane] Activated FGFR:p-FRS2-alpha [plasma membrane] Activated FGFR:p-FRS2-alpha:p-SHP2 [plasma membrane] Activated MASP-1 dimer [extracellular region] Activated MASP-2 dimer [extracellular region] Activated MBL bound to mannose-based carbohydrates on bacterial surfaces [plasma membrane] Activated mTORC1 [cytosol] Activated PAR1 [plasma membrane] U K E G B C d O R H U R P P P P P Activated PAR3 [plasma membrane] U K E G B C d O R H U R Activated PAR4 [plasma membrane] U K E G B C d O R H U R Activated PI3K [plasma membrane, endosome membrane] Activated PKC alpha [plasma membrane] Activated PKC beta [plasma membrane] Activated PLC gamma release by activated FGFR [Homo sapiens] Activated Rac1:PI3K alpha [cytosol] Activated TLR1:2 or TLR4:4 or TLR5:TLR5 or TLR 2:6 or TLR7:TLR7 or or TLR8:TLR8 or TLR9:TLR9 or TLR10:TLR10 receptor [plasma membrane, endosome membrane] Activated TLR4 signalling [Homo sapiens] Activated TLR9 bound to PI3K class III [endosome membrane] Activation of C1R [Homo sapiens] Activation of C1S [Homo sapiens] Activation of C3 and C5 [Homo sapiens] Activation of C5 [Homo sapiens] Activation of conventional Protein Kinase C [Homo sapiens] Activation of MBL [Homo sapiens] Activation of PKB [Homo sapiens] Activation of S6K1 [Homo sapiens] Adenosine A3 receptor [plasma membrane] U K E G B C d O R H U R P Adhesion of alpha IIb beta 3 integrin to fibrin network [Homo sapiens] Adhesion via alpha 2 beta 1 glycoprotein [Homo sapiens] ADP [extracellular region] C C P ADP [platelet dense granule lumen] C C P ALCAM [plasma membrane] U K E G B C d O R H U R P Alpha 2 Beta 1 Integrin : Collagen IV: Mg++ complex [plasma membrane] Alpha 2 Beta 1 Integrin [plasma membrane] Alpha 5 Beta 1 Fibronectin receptor [plasma membrane] Alpha 5 Beta 1 Fibronectin receptor bound to Fibronectin [plasma membrane] Alpha IIb Beta 3 Integrin [plasma membrane] Alpha IIb Beta 3 Integrin [platelet alpha granule membrane] Alpha-1-antitrypsin [extracellular region] U K E G B C d O R R R H H H U R R R P P P P P P P P P P P P P P P Alpha-1-antitrypsin [platelet alpha granule lumen] U K E G B C d O R R R H H H U R R R P P P P P P P P P P P P P P P Alpha-2-antiplasmin [extracellular region] U K E G B C d O R H U R Alpha-2-antiplasmin [platelet alpha granule lumen] U K E G B C d O R H U R Alpha-2-macroglobulin [platelet alpha granule lumen] U K E G B C d O R H U R P Alpha-actinin 4 [platelet alpha granule lumen] U K E G B C d O O R H U R P P Alternative complement activation [Homo sapiens] Amyloid beta A4 protein precursor [platelet alpha granule lumen] U K E G B C d O O O O R H U R P P P P P P P P P P P P P P P P P P P P P P P P P P P P P Angiopoietin 1 receptor precursor [plasma membrane] U K E G B C d O O R H U R P P Antigen [plasma membrane] Antigen-antibody complex [plasma membrane] Antigen-bound antibody bound to lymphoid Fc gamma receptors [plasma membrane] Antigen-bound Ig G Antibody [extracellular region] Antigen: antibody: C1 (activated C1R and C1S) complex [plasma membrane] Antigen: antibody: C1 (activated C1R) complex [plasma membrane] Antigen: antibody: C1 complex [plasma membrane] Association of LBP with LPS [Homo sapiens] Association of TRAM to activated TLR4 [Homo sapiens, Chlamydia trachomatis, etc.] Association of TRIF to TRAM complexed to activated TLR4 [Homo sapiens, Chlamydia trachomatis, etc.] Autocatalytic phosphorylation of FGFR1b [Homo sapiens] Autocatalytic phosphorylation of FGFR1c [Homo sapiens] Autocatalytic phosphorylation of FGFR2b [Homo sapiens] Autocatalytic phosphorylation of FGFR2c [Homo sapiens] Autocatalytic phosphorylation of FGFR3b [Homo sapiens] Autocatalytic phosphorylation of FGFR3c [Homo sapiens] Autocatalytic phosphorylation of FGFR4 [Homo sapiens] Autocatalytic phosphorylation of Klotho-bound FGFR1c [Homo sapiens] B- and T-lymphocyte attenuator precursor [plasma membrane] U K E G B C d O R H U R P B-lymphocyte activation marker BLAST-1 precursor [plasma membrane] U K E G B C d O R H U R B-lymphocyte antigen CD19 precursor [plasma membrane] U K E G B C d O R H U R Bacterial mannose-based carbohydrate surface pattern [plasma membrane] Basigin binds CyPA [Homo sapiens] Basigin binds MCT1, MCT3 and MCT4 [Homo sapiens] Basigin binds to integrins [Homo sapiens] Basigin bound to CD43 [plasma membrane] Basigin bound to CyPA [plasma membrane] Basigin bound to integrins [plasma membrane] Basigin bound to MCTs [plasma membrane] Basigin homodimer [plasma membrane] Basigin homodimerises [Homo sapiens] Basigin interacts with CD43 [Homo sapiens] Basigin precursor [Golgi membrane] U K E G B C d O O R H U R R Basigin precursor [plasma membrane] U K E G B C d O O R H U R R Basigin-binding integrins [plasma membrane] Beta-thromboglobulin [extracellular region] U K E G B C d O R H U R P P P Beta-thromboglobulin [platelet alpha granule lumen] U K E G B C d O R H U R P P P Betaproteobacteria Binding of GP VI:Fc Epsilon R1 gamma receptor complex with collagen [Homo sapiens] Binding of GRB2 and GAB1 to Activated FGFR:p-FRS2-alpha:p-SHP2 [Homo sapiens] Binding of IP3 to IP3 receptor [Homo sapiens] Binding of Syk tyrosine kinase [Homo sapiens] BOC [plasma membrane] U K E G B C d O R H U R Brain-cadherin [plasma membrane] U K E G B C d O R R R R R H U R C-terminal modulator protein [cytosol] U K E G G G B B B C C C d d d R H U R C1 complement factor (with activated C1R and C1S) [extracellular region] C1 complement factor (with activated C1R) [extracellular region] C1 complement factor [extracellular region] C1Q [extracellular region] C1Q subunit (C1QA:C1QB:C1QC heterotrimer) [extracellular region] C1QA [extracellular region] U K E G B C d O R H U R P C1QB [extracellular region] U K E G B C d O R H U R P C1QC [extracellular region] U K E G B C d O R H U R P C1R [extracellular region] U K U C1R C-terminal fragment [extracellular region] U K U C1R N-terminal fragment [extracellular region] U K U C1S [extracellular region] U K E G B C d O R R H H U R R P P D C1S C-terminal fragment [extracellular region] U K E G B C d O R R H H U R R P P D C1S N-terminal fragment [extracellular region] U K E G B C d O R R H H U R R P P D C1S:activated C1R tetramer [extracellular region] C1S:C1R tetramer [extracellular region] C3 alpha chain [extracellular region] U K E G G B B C C d d O R H U R P P P P P P P P P D C3 alpha chain H2O [extracellular region] U K E G G B B C C d d O R H U R P P P P P P P P P D C3 beta chain [extracellular region] U K E G G B B C C d d O R H U R P P P P P P P P P D C3 convertase [plasma membrane, extracellular region] C3(H2O):Factor B [extracellular region] C3(H2O):Factor Bb [extracellular region] C3(H2O):Factor Bb [extracellular region] C3(H2O):Factor Bb-mediated C3 cleavage leads to C3b deposition on a target cell surface [Homo sapiens] C3a [extracellular region] U K E G G B B C C d d O R H U R P P P P P P P P P D C3b [extracellular region] C3b [plasma membrane] C3b alpha' [extracellular region] U K E G G B B C C d d O R H U R P P P P P P P P P D C3b:C3b:Factor Bb: Properdin complex [extracellular region, plasma membrane] C3b:Factor B complex [plasma membrane] C3b:Factor Bb complex [plasma membrane] C3b:Factor Bb:Properdin complex [plasma membrane] C3d complexed with antigen [extracellular region] C3d fragment [extracellular region] U K E G G B B C C d d O R H U R P P P P P P P P P D C3d-complexed antigen binds to complement receptor [Homo sapiens] C4 activator [plasma membrane] C4b:C2b complex [plasma membrane] C4b:C2b:C3b complex [plasma membrane] C5 alpha chain [extracellular region] U K E G B C d O O R H U R P P P C5 beta chain [extracellular region] U K E G B C d O O R H U R P P P C5 convertase [plasma membrane, extracellular region] C5a [extracellular region] U K E G B C d O O R H U R P P P C5b [extracellular region] C5b alpha' [extracellular region] U K E G B C d O O R H U R P P P C5b:C6 complex [extracellular region] C5b:C6:C7 complex [extracellular region] C5b:C6:C7 complex [plasma membrane] C5b:C6:C7:C8 complex [plasma membrane] C5b:C6:C7:C8: 12xC9 membrane attack complex [plasma membrane] C6 [extracellular region] U K E G B C d O R H U R C7 [extracellular region] U K E G B C d O O R H U R C7 allows complex to insert into membrane under attack [Homo sapiens] C8 [extracellular region] C8 Alpha [extracellular region] U K E G B C d O R H U R C8 Beta [extracellular region] U E G B C d O R H U R C8 Gamma [extracellular region] U K E G B C d O R H U R P P C9 [extracellular region] U K E G B C d O R H U R Cadherin-3 precursor [plasma membrane] U K E G B C d O O O R H U R Calcium [platelet dense granule lumen] C C P Calcium [platelet dense tubular network lumen] C C P Calcium [platelet dense tubular network membrane] C C P calcium channel activity of IP3 receptor bound to IP3 and Ca++ [platelet dense tubular network membrane] calcium channel activity of P2X1 purinoreceptor bound to ATP [plasma membrane] calcium-dependent protein kinase C activity of Activated conventional protein kinase C [plasma membrane] Carcinoembryonic antigen-related cell adhesion molecule 1 precursor [plasma membrane] U E G B C d O R H U R Carcinoembryonic antigen-related cell adhesion molecule 6 precursor [plasma membrane] U K E G B C d O R H U R Carcinoembryonic antigen-related cell adhesion molecule 8 precursor [plasma membrane] U K E G B C d O R H U R caveolin-1 [Golgi membrane] U E G B C d O R H U R Caveolin-1 binds Basigin [Homo sapiens] Caveolin-1 bound to Basigin [Golgi membrane] CBL [cytosol] U K E G B C d O R H U R P P P P CBL [plasma membrane] U K E G B C d O R H U R P P P P CD14 [extracellular region, plasma membrane] CD160 antigen precursor [plasma membrane] U K E G B C d O R H U R CD177 antigen precursor [plasma membrane] U K U CD177 binds PECAM-1 [Homo sapiens] CD200 binds to CD200R [Homo sapiens] CD200 bound to CD200R [plasma membrane] CD21 protein [plasma membrane] U U CD226 antigen precursor [plasma membrane] U K E G B C d O R H U R CD226 bound to Nectin 2 [plasma membrane] CD226 bound to nectin-like 5 [plasma membrane] CD28 homodimer [plasma membrane] CD3 epsilon delta [plasma membrane] CD3 epsilon gamma [plasma membrane] CD34 [plasma membrane] U K E G B C d O R H U R CD40 complexed with CD40L [plasma membrane] CD40 interacting with CD40L [Homo sapiens] CD47 [plasma membrane] U K E G B C d O R H U R CD47 binds SIRP [Homo sapiens] CD47 bound to its ligand [plasma membrane] CD47-binding SIRPs [plasma membrane] CD48 binds CD244 [Homo sapiens] CD48 bound to CD244 [plasma membrane] CD58 binds CD2 [Homo sapiens] CD58 bound to CD2 [plasma membrane] CD63 antigen [plasma membrane] U E G B C d O R R H H U R R CD72 [plasma membrane] U K E G B C d O R H U R CD8 [plasma membrane] CD80 (B7-1) homodimer [plasma membrane] CD80 [plasma membrane] U K E G B C d O R H U R P P CD81 antigen [plasma membrane] U K E G B C d O R H U R P P CD84 [plasma membrane] U K E O U CD84 Homodimer [plasma membrane] CD84 homodimerises [Homo sapiens] CD86 monomer [plasma membrane] U K E G B C d O R H U R R P P CD9 antigen [platelet alpha granule membrane] U K E G B C d O R H U R CD96 binds Nectin-like-5 [Homo sapiens] CDO [plasma membrane] U K E G B C d O U CEACAM heterodimer [plasma membrane] Cell surface glycoprotein OX2 receptor precursor [plasma membrane] U K E G B C d O R R H H U R R Cell surface interactions at the vascular wall [Homo sapiens] Chlamydia Chlamydia trachomatis Chlamydiaceae Chlamydiae Chlamydiae (class) Chlamydiae/Verrucomicrobia group Chlamydial HSP60 [extracellular region] U Chlamydial HSP60 binding to TLR4 [Homo sapiens, Chlamydia trachomatis] Chlamydial HSP60 bound to TLR4 [plasma membrane] Chlamydiales class I MHC B13 [plasma membrane] U E G B C d O O O U P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P class I MHC B14 [plasma membrane] U E O U P P P P P P P class I MHC B15 [plasma membrane] U E G B C d O O O U P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P class I MHC B18 [plasma membrane] U E G B C d O O O U P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P class I MHC B27 [plasma membrane] U E G B C d O O O U P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P class I MHC B35 [plasma membrane] U E G B C d O O O U P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P class I MHC B37 [plasma membrane] U E G B C d O O O U P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P class I MHC B38 [plasma membrane] U E O U P P P P P P P class I MHC B39 [plasma membrane] U E O U P P P P P P P class I MHC B40 [plasma membrane] U E G B C d O O O U P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P class I MHC B41 [plasma membrane] U E O U P P P P P P P class I MHC B42 [plasma membrane] U E G B C d O R H U R Classical antibody-mediated complement activation [Homo sapiens] Cleavage of C3 by C3 convertase [Homo sapiens] Clostridial peptidoglycan [extracellular region] P Coagulation factor VIII precursor [platelet alpha granule lumen] U K E G B C d O O R H U R P P P P Collagen adhesion via alpha 2 beta 1 glycoprotein [Homo sapiens] Collagen adhesion via Gp IV [Homo sapiens] Collagen alpha 1(I) chain precursor [plasma membrane] U K E G B C d O O O O O O O O R H U R P Collagen alpha 2(I) chain precursor [extracellular region] U K E G B C d O O O O O O O R H U R Collagen alpha 3(IV) chain [extracellular region] U K E G B C d O O O R R R R H H H H U R R R R Collagen I (alpha 1, alpha 1, alpha 2) [extracellular region] Collagen I (alpha 1, alpha 1, alpha 2) [plasma membrane] Collagen I [extracellular region] Collagen I [plasma membrane] Collagen IV : vWF complex [extracellular region] Complement cascade [Homo sapiens] Complement factor 2 [extracellular region] U K E E E G B C d O R H U R Complement factor 2a [extracellular region] U K E E E G B C d O R H U R Complement factor 2b [extracellular region] U K E E E G B C d O R H U R Complement factor 3 [extracellular region] Complement factor 3(H2O) [extracellular region] Complement factor 3(H2O) [extracellular region] Complement factor 4 [extracellular region] Complement factor 4 alpha chain [extracellular region] U K E G B C d O O O R H U R P Complement factor 4 beta chain [extracellular region] U K E G B C d O O O R H U R P Complement factor 4 fragment a [extracellular region] U K E G B C d O O O R H U R P Complement factor 4 fragment b [extracellular region] U K E G B C d O O O R H U R P Complement factor 4 gamma chain [extracellular region] U K E G B C d O O O R H U R P Complement factor 5 [extracellular region] Complement Factor B [extracellular region] U K E E G B C d O R H U R P P P P P Complement Factor Ba [extracellular region] U K E E G B C d O R H U R P P P P P Complement Factor Bb [extracellular region] U K E E G B C d O R H U R P P P P P Complement Factor Bb [plasma membrane] U K E E G B C d O R H U R P P P P P Complement factor D precursor [platelet alpha granule lumen] U K E G B C d O R H U R P P P P P P P Complex of Activated FGFR with SHC [plasma membrane] Complex of CD19, CD81, CD225 and CD21 [plasma membrane] Complex of CD19, CD81, CD225 and CD21 with C3d-bound Antigen [plasma membrane] Conversion of C2 into C2a and C2b [Homo sapiens] Conversion of C4 into C4a and C4b [Homo sapiens] Coxsackievirus and adenovirus receptor [plasma membrane] U K E G B C d O R H U R P P P P P P P P P Creation of C4 and C2 activators [Homo sapiens] Creation of the Membrane Attack Complex (MAC) [Homo sapiens] CRTAM binds to NECL2 [Homo sapiens] CRTAM bound to NECL2 [plasma membrane] CTLA-4 [plasma membrane] U K E G B C d O O O O O R H U R P P P P CTLA-4 homodimer [plasma membrane] CXADR binds to AMICA1 [Homo sapiens] CXADR bound to JAML [plasma membrane] CyP60 chaperones Basigin [Homo sapiens] CyP60 complexed with Basigin [Golgi membrane] CypA protein [extracellular region] U K E E G G G G G G G G B B B B B B B B C C C C C C C C d d d d d d d d O R R H H U R P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P D D D D D D D D D D D D D Cytotoxic and regulatory T cell molecule [plasma membrane] U K E G B C d R H U R DAP10 [plasma membrane] U K E G B C d R R H H U R R DAP12 [plasma membrane] U K E G B C d O O R R H H U R R DCC [plasma membrane] U K E G B C d O R H U R Diacyl lipopeptide [extracellular region] Dimerisation of phosphorylated IRF3 [Homo sapiens, Chlamydia trachomatis, etc.] Dimerization of Phospho IRF3 or phospho IRF7 [Homo sapiens] Disinhibition of SNARE formation [Homo sapiens] Dissociation of IRAK1-P(n) from TLR [Homo sapiens, Chlamydia trachomatis, etc.] Dissociation of phosphorylated 4EBP1 from eIF4E [Homo sapiens] Downstream signaling of activated FGFR [Homo sapiens] Duffy antigen/chemokine receptor [plasma membrane] U K E G B C d O R H U R E-cadherin bound to KLRG1 [plasma membrane] E-cadherin bound to KLRG1 [plasma membrane] EEA1 [endosome membrane] U K E G B C d O R H U R P P P EEA1 homodimer [endosome membrane] eEF2K [cytosol] U K E G B C d O R H U R eEF2K-P [cytosol] U K E G B C d O R H U R Effects of IP3 [Homo sapiens] Effects of PIP2 hydrolysis [Homo sapiens] eIF4B-P [cytosol] U K E G B C d O R H U R P eIF4E:4E-BP1-P [cytosol] eIF4G-P [cytosol] U E G B C d O R R H H U R R R R R P P Elevation of cytosolic Ca2+ levels [Homo sapiens] Endothelial cell-selective adhesion molecule precursor [plasma membrane] U K E G B C d R H U R Engulfed CpG DNA binds to endosomal TLR9 [Homo sapiens] Epithelial cadherin binds to KLRG1 [Homo sapiens] Epithelial cadherin binds to KLRG1 in mice [Mus musculus] Epithelial-cadherin precursor [plasma membrane] U K E G B C d O O O R H U R P Epithelial-cadherin precursor [plasma membrane] U K E G B C d R H R P P P P P P Factor B binds to Complement factor 3(H2O) (C3(H2O)) [Homo sapiens] Factor B binds to surface-associated C3b [Homo sapiens] Factor D cleaves C3(H2O)-bound Factor B [Homo sapiens] Factor D cleaves C3b-bound Factor B [Homo sapiens] Fc gamma receptors interact with antigen-bound IgG [Homo sapiens] FGF10 [extracellular region] U K E G B C d O O R H U R P D FGF23 bound to Klotho and FGFR1c [plasma membrane] FGFR 1b binding FGFs [extracellular region] FGFR 1c binding FGFs [extracellular region] FGFR 2b binding FGFs [extracellular region] FGFR 2c binding FGFs [extracellular region] FGFR 3b binding FGFs [extracellular region] FGFR 3c binding FGFs [extracellular region] FGFR binds FRS2 [Homo sapiens] FGFR ligand binding and activation [Homo sapiens] FGFR1 ligand binding and activation [Homo sapiens] FGFR1b binds to FGF [Homo sapiens] FGFR1b homodimer [plasma membrane] FGFR1b homodimer bound to FGF [plasma membrane] FGFR1b ligand binding and activation [Homo sapiens] FGFR1c and Klotho ligand binding and activation [Homo sapiens] FGFR1c binds to FGF [Homo sapiens] FGFR1c binds to Klotho-bound FGF23 [Homo sapiens] FGFR1c homodimer [plasma membrane] FGFR1c homodimer bound to FGF [plasma membrane] FGFR1c ligand binding and activation [Homo sapiens] FGFR2 ligand binding and activation [Homo sapiens] FGFR2b binds to FGF [Homo sapiens] FGFR2b ligand binding and activation [Homo sapiens] FGFR2b long homodimer [plasma membrane] FGFR2b long homodimer bound to FGF [plasma membrane] FGFR2c binds to FGF [Homo sapiens] FGFR2c ligand binding and activation [Homo sapiens] FGFR2c long homodimer [plasma membrane] FGFR2c long homodimer bound to FGF [plasma membrane] FGFR3 ligand binding and activation [Homo sapiens] FGFR3b binds to FGF [Homo sapiens] FGFR3b homodimer [plasma membrane] FGFR3b homodimer bound to FGF [plasma membrane] FGFR3b ligand binding and activation [Homo sapiens] FGFR3c binds to FGF [Homo sapiens] FGFR3c homodimer [plasma membrane] FGFR3c homodimer bound to FGF [plasma membrane] FGFR3c ligand binding and activation [Homo sapiens] FGFR4 binding FGFs [extracellular region] FGFR4 binds to FGF [Homo sapiens] FGFR4 homodimer [plasma membrane] FGFR4 homodimer bound to FGF [plasma membrane] FGFR4 ligand binding and activation [Homo sapiens] fibrin multimer [extracellular region] fibrin multimer [plasma membrane] fibrinogen [extracellular region] fibrinogen [platelet alpha granule lumen] Fibroblast growth factor receptor 1b [plasma membrane] Fibroblast growth factor receptor 1c [plasma membrane] U K E G B C d O O O O O O R H U R R P P P P P P P P P D D D Fibroblast growth factor receptor 2 precursor [plasma membrane] U K E G B C d O O O O O O O O O R H U R P P P P P P P P P P D D Fibroblast growth factor receptor 2b long [plasma membrane] U K E G B C d O O O O O O O O O R H U R P P P P P P P P P P D D Fibroblast growth factor receptor 2c long [plasma membrane] U K E G B C d O O O O O O O O O R H U R P P P P P P P P P P D D Fibroblast growth factor receptor 3b [plasma membrane] U K