Signaling by GPCR

• - GPCR downstream signaling
• - G-protein beta:gamma signalling
• - G beta:gamma signalling through PI3Kgamma
• - G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 [Homo sapiens]
• - PIP3 recruits PDK1 and AKT to the membrane [Homo sapiens]
• - PIP3 binds to RhoA and activates it [Homo sapiens]

Signaling in Immune system

• - TCR signaling
• - Downstream TCR signaling
• - Phosphorylation of PKC theta [Homo sapiens]
• - Translocation of CARMA1 to Plasma membrane [Homo sapiens]
• - Phosphorylation of CARMA1 [Homo sapiens]
• - Oligomerization of CARMA1 [Homo sapiens]
• - Interaction of Bcl10 to CARMA1 [Homo sapiens]
• - Phosphorylation of Bcl10 [Homo sapiens]
• - Oligomerization of Bcl10 [Homo sapiens]
• - Interaction and oligomerization of MALT1 to Bcl10 [Homo sapiens]
• - Translocation of TRAF6 to CBM complex [Homo sapiens]
• - Auto-ubiquitination of TRAF6 [Homo sapiens]
• - Activation of TAK1-TAB2 complex [Homo sapiens]
• - Activation of IKK complex [Homo sapiens]
• - Ubiquitination of NEMO by TRAF6 [Homo sapiens]
• - PI3K phosphorylates PIP2 to PIP3 [Homo sapiens]
• - Translocation of PDK1 to Plasma membrane [Homo sapiens]
• - Hydrolysis of PIP3 to PI(3,4)P2 [Homo sapiens]
• - Hydrolysis of PIP3 to PIP2 [Homo sapiens]
• - Costimulation by the CD28 family
• - CD28 co-stimulation
• - CD28 dependent PI3K/Akt signaling
• - CD28 bound PI3K phosphorylates PIP2 to PIP3 [Homo sapiens]
• - PIP3 recruits PDK1 and AKT to the membrane [Homo sapiens]
• - PDK1 phosphorylates AKT at T308 [Homo sapiens]
• - TORC2 (mTOR) phosphorylates AKT at S473 [Homo sapiens]
• - AKT interacts and phosphorylates Cot [Homo sapiens]
• - Akt:pCot phosphorylates NIK [Homo sapiens]
• - CD28 dependent Vav1 pathway
• - Translocation of Vav1 to CD28 [Homo sapiens]
• - Activation of Vav1 [Homo sapiens]
• - Activation of Rac1 by pVav1 [Homo sapiens]
• - Activation of Cdc42 by pVav1 [Homo sapiens]
• - CTLA4 inhibitory signaling
• - Dephosphorylation of AKT by PP2A [Homo sapiens]

Signaling by EGFR

• - Gab1 signalosome
• - PI3K converts Phosphatidylinositol-4,5-bisphosphate to Phosphatidylinositol-3,4,5-trisphosphate [Homo sapiens]
• - Gab1 binds phosphatidylinositol-3,4,5-trisphosphate [Homo sapiens]

Hemostasis

• - Formation of Platelet plug
• - Platelet Activation
• - Platelet activation triggers
• - GPVI-mediated activation cascade
• - PI3K alpha, beta, gamma convert PIP2 to PIP3 [Homo sapiens]
• - PIP3 recruits PDK1 and AKT to the membrane [Homo sapiens]
• - PIP3 stimulates Vav [Homo sapiens]
• - PDK1 binds PKC zeta [Homo sapiens]
• - PDK1 activates PKC zeta [Homo sapiens]

Signalling by NGF

• - NGF signalling via TRKA from the plasma membrane
• - PI3K/AKT signalling
• - PI3K produces PIP3 and other phosphatidyl inositides [Homo sapiens]
• - PIP3 recruits PDK1 and AKT to the membrane [Homo sapiens]
• - PIP3 binds to RhoA and activates it [Homo sapiens]
• - PDK1 phosphorylates AKT at T308 [Homo sapiens]
• - TORC2 (mTOR) phosphorylates AKT at S473 [Homo sapiens]
• - AKT phosphorylates targets in the cytosol
• - AKT phosphorylates BAD [Homo sapiens]
• - AKT phosphorylates GSK3 [Homo sapiens]
• - AKT phosphorylates caspase-9 [Homo sapiens]
• - AKT phosphorylates MDM2 [Homo sapiens]
• - AKT phosphorylates IKKalpha [Homo sapiens]
• - AKT phosphorylates p21Cip1 and p27Kip1 [Homo sapiens]
• - AKT phosphorylates TSC2, inhibiting it [Homo sapiens]
• - AKT phosphorylates PRAS40 [Homo sapiens]
• - Negative regulation of the PI3K/AKT network
• - PTEN dephosphorylates PIP3 [Homo sapiens]

Signaling by FGFR

• - Downstream signaling of activated FGFR
• - Phospholipase C-mediated cascade
• - Activated FGFR binds PLC gamma [Homo sapiens]
• - PLC gamma phosphorylation by FGFR [Homo sapiens]

Signaling by PDGF

• - Down-stream signal transduction
• - PI3K catalyses the phosphorylation of PIP2 to PIP3 [Homo sapiens]