Reactome: Garapati, P V

Details

Author of summation(s)
Surname	Garapati
First name	Phani Vijay
Initials	P V
A costimulatory signal involved in T cell activation is tran... A low level of Rac activity is essential to maintain axon ou... Abl associated with Robo1, Slit2, and glypican at the plasma... Abl binds directly, via its SH3 domain, to the CC3 motif in ... ABL binds to the cytoplasmic tail of CDO and also to the p38... Abl kinase phosphorylates the tyrosine residue (1073) of the... Abl plays a dual role in the Robo pathway. As a key enzymati... Activated (phosphorylated) FADK1 acts as a scaffold and recr... Activated LIM-kinase a cytosolic Ser/Thr kinase phosphorylat... Activated PAK kinase phosphorylates LIM-kinase at threonine ... Activated PLA-gamma1 translocates to the plasmamembrane and ... Activated Rac1 bound to plexin-A might modulate actin dynami... Activation of Src kinases involves displacement of Tyr527 fr... Active Rac1 associates directly with Plexin-A1 in the linker... After dimerization of the PDGF-A and PDGF-B chains in the ER... After phosphorylation on Thr 508, LIMK undergoes homodimeriz... After Platelet activation '78 kDa glucose-regulated protein'... After Platelet activation 'Calumenin' from the endoplasmic r... After Platelet activation 'Proactivator polypeptide' from th... After the generation of PIP3 by PI3K, a part of it is furthe... After the phosphorylation and activation CARMA1 undergoes ol... After trans-autophosphorylation of tyrosine 418, Csk kinase ... Agrin, a Heparin Sulfate Proteoglycan (HSPG), plays a role i... All the newly synthesized PDGF chains are dimerized in the E... Alpha v beta 3 integrin is one of the potential heterophilic... alphaIIbbeta3 and c-Src clusterings results in the trans aut... Although neuropilin-1 is required for Sema-3A action, it is ... Among netrin1 receptors neogenin is the only protein to inte... Among the seven members of the Stat family, Stat1, Stat3, St... Ang4 represents a third protein of the Ang family that binds... Ankyrins are a family of adaptor proteins that couple membra... Ankyrins are bifunctional linker proteins that tether L1 to ... Ankyrins link both L1 and ion channel proteins, coupling the... Antigen receptor triggered PKC theta dependent linker phosph... Antiparallel NCAM interactions involve trans-interactions of... As integrins do not have an intrinsic catalytic activity, th... Association with RIP2 and its phosphorylation allows subsequ... At the sites of vascular injury bioactive molecules such as ... Axon guidance / axon pathfinding is the process by which neu... Axonin-1 expressed on the commissural axons interacts in tra... Based on in vitro affinity chromatography study, basigin was... Basigin (Bsg) is a highly glycosylated transmembrane protein... Basigin expressed on the surface of most tumor cells, stimul... Basigin is a widely distributed cell-surface protein with tw... Basigin is a widely expressed transmembrane glycoprotein tha... Basigin serves as a signaling receptor for extracellular cyc... Bcl10 interacts with the oligomerized CARMA1 and this is med... Bcl10 is recruited to activated, oligomeric CARMA1 through a... Besides adhesive roles in cell cell interaction, L1 function... Binding of ankyrins is dependent on the phosphorylation and ... Binding of Hsp90 to the LIMK proteins protects them from deg... Binding of Sema3A to the Neuropilin-1-Plexin-A receptor comp... Bnip-2 interacts with Cdc42 through its Bnip-2 and Cdc42GAP ... Bnip-2 is a scaffold protein with a single recognizable moti... By analogy to the well-studied chicken system, L1 can be coe... By analogy to the well-studied chicken system, L1 heterophil... CARMA1 and Bcl10 are the possible link between PKC theta and... CD28 binds to several intracellular proteins including PI3 k... CD28 delivers the costimulatory signal by interacting with i... CD28 is capable of binding the Src homology 3 (SH3) domains ... CD43, a major leukocyte cell surface sialoglycoprotein, inte... CD97hc is a multifunctional glycoprotein with a single trans... Cdk5:p35 complex is associated with Plexin-A through the act... Cdk5:p53 complex is recruited to the growth cone by associat... CDO and BOC form complexes in a cis fashion via association ... CDO selectively binds to neogenin in a cis fashion and this ... CDO/Cdon (cell-adhesion-molecule-related/downregulated by on... Changes in gene expression are required for the T cell to ga... CHL1 associates with the sub-membranous actin cytoskeleton t... CHL1 binds the Sema3A receptor, Neuropilin-1 (NP-1), via a c... CHL1 interacts with alpha1beta1/alpha2beta1 integrins in cis... CKII phosphorylates L1CAM at serine 1181, just after the AP-... CLASP acts positively downstream of Abl as part of the repel... Close homolog of L1 (CHL1) is a member of the L1 family of c... Close homolog of L1 (CHL1), associates with Contactin-6/NB-3... Colonic epithelial cells use integrin alpha2beta1 to adhere ... Commissural axons project to the floor plate, attracted by t... Cot functions upstream of NIK in the CD28-costimulation sign... Cot/Tpl 2 is a serine/threonine kinase of the mitogen activa... Crk family of adaptor molecules consists of CrkI with one SH... Crk is an adaptor protein with one SH2 and two SH3 domains. ... CRMP-3 does not have the conserved serine 522 and based on s... CRMPs are a small family of plexinA-interacting cytosolic ph... Csk is a tyrosine kinase that phosphorylates the negative re... CTLA4 associates with the SH2 domain containing tyrosine pho... CTLA4 binds with high affinity to the ligands B71 and B72. T... CTLA4 is one of the best studied inhibitory receptors of the... Cyclophilin A (CyPA)1 is an intracellular protein belonging ... DCC and Robo1 heterodimerize via conserved sequence elements... DCC and UNC5A, are also receptors for Netrin-4. The LNT doma... DCC exerts its pro-apoptotic effect when netrin ligand is ab... DCC interacts directly with PITPalpha and this interaction i... DCC interacts with the SH3/SH2 adaptor NCK1 in commissural n... DM GRASP/ALCAM/BEN is one of the heterodimerizing partners ... Dock/Nck bound to Robo recruits Pak to specific sites at the... Dok-2 is a member of a docking proteins class, termed the DO... Doublecortin is a microtubule associated protein expressed i... During the extracellular proteolytic activation of PDGF-C an... During the phosphorylation of the IKK beta, the regulatory s... Dynamin is a neuronal phosphoprotein and a GTPase enzyme whi... E-cadherin, memeber of the cadherin superfamily is a calcium... Ena is required in part for Robo's repulsive output. Ena is ... Ena/VASP proteins enhance actin filament elongation via the ... Endocytosis is followed by the vesicular transport and recyc... EPH kinase Cek5/EPHB2 phosphorylates tyrosine residue in the... Ezrin is a member of the ezrin/radixin/moesin (ERM) family t... Ezrin Radixin Moesin (ERM) are the members of the FERM domai... FADK1 interacts with the C-terminal P3 domain of DCC complex... Fes bound to Plexin-A is able to phosphorylate all five form... FGFR is one of the heterophilic interactors of NCAM. The FG ... Fibrillins are the main constituents of the extracellular mi... Fibronectin plays a role in cell adhesion and cell migration... Fibronectin serves as the main ligand for the integrin alpha... Fyn activation leads to the recruitment and activation of th... Fyn constitutively associates with the 140 kD isoform of NCA... Gads (Grb2-related adaptor protein 2) is essential for CD28 ... Gads is a member of the Grb2 family containing SH2 and SH3 ... GFRalpha receptors GFRalpha1 and possibly also GFRalpha2 and... Grb14 is also one of the signaling partners of Tie2. The SH2... Grb2 binds directly to autophosphorylated Tie2 receptor. GRB... Grb7 an adapter protein contains a single SH2 domain, a plec... Grb7 was initially identified as an EGF receptor binding pro... Guanine nucleotide releasing factor Sos associates with FAK ... Heat-stable antigen (HSA/mouse CD24) is expressed in both ha... Hsc70 binds to the intracellular domain of CHL1. This intera... In addition to serving as a scaffold via auto-phosphorylatio... In its bound state PAK dimers are arranged in head-to-tail f... In its unbound state PAK is maintained in an inactive confor... In myoblasts, CDO forms cis complexes with the cell–cell adh... In naive T cells, CD28 costimulation enhances cell cycle ent... In response to the TCR stimulation, phsophoinositides are ph... In the immune system, Sema4D/CD100 binds CD72 to mediate B-c... In the presence of Netrin1, DCC and UNC5 generate attractive... In ZAP-70 there are multiple phosphorylation sites (Y292, Y3... Inducible T cell co-stimulatory (ICOS) protein is the third ... Integrin alpha9beta1 is widely expressed on smooth muscle, e... Integrin alphaVbeta3 a vitronectin receptor is highly expres... Integrin alphaVbeta3 interacts with von Willebrand factor (v... Integrin alphaVbeta3 receptor has been implicated in various... Integrin signaling is linked to the MAP kinase pathway by re... Integrin signaling is linked to the MAP kinase pathway by re... Interaction with ankyrins mediates the lateral oligomerizati... Interaction with ERM may lead to lateral oligomerization of ... ITK is a member of the Tec protein tyrosine kinase family wh... JLP is a p38 alpha/beta MAPK scaffold protein. p38 alpha/bet... JLP is a scaffold protein for the p38 MAPK pathway. During m... L1 and NCAM1 co-expressed on a single cell interact with eac... L1 and RanBPM interact with one another and the N-terminus o... L1 can function as a trans-heterophilic ligand for multiple ... L1 cross linking can activate MAPK cascade components MEK1/2... L1 crosslinking leads to the tyrosine phosphorylation and ac... L1 functions in many aspects of neuronal development includi... L1 in the C-domain membrane is internalized via clathrin med... L1 interacts with neuropilin 1 (NP-1) through a conserved se... L1 recruits membrane skeletal component ankyrin to cell to c... L1 translocated to the non raft membranes of the C-domain is... L1 transported to the P-domain of growth cones is reinserted... L1-L1 trans-homodimers interact with the fibroblast growth f... L1CAM and EGFR engage in a weak heterophilic trans interacti... L1CAM binds with high affinity to the proteoglycan neurocan.... Laminins are a group of large, adhesive glycoproteins found ... Later ZAP-70 undergoes trans-autophosphorylation at Y315 and... Lck is a member of the Src family tyrosine kinases and these... Like SHP-1 and SHP-2, PLC-gamma 1 also interacts with PECAM-... Membrane bound L1 is internalized through clathrin coated ve... Multiple sites on Unc5c are phosphorylated after netrin-1 st... MyoD is a basic helix loop helix (bHLH) myoblast specific tr... MyoD-E protein heterodimers interact with MEF2 proteins to s... Myosin-X, an unconventional myosin implicated in cell adhesi... NCAM in the developing brain is highly polysialylated and is... NCAM was identified as an alternative signaling receptor for... NCAM1 associates with T- and L-type voltage-dependent Ca+2 c... NCAM1 bind all major components of neurocan (N-terminal, cen... NCAM1 binds with high affinity to the neuronal IgSF receptor... NCAM1 has been demonstrated to possess (Ca++ or Mg++) depend... NCAM1 interacts with several extracellular matrix proteins. ... NCAM1 located on the cell membrane can participate in parall... Nck is a widely expressed protein consisting exclusively of ... Netrin binding to DCC causes DCC clustering via its P3 domai... Netrin-1 is not only involved as an axon guidance cue during... Netrin-1 promotes attraction of the commissural neurons to m... Netrin-1 stimulates phosphorylation of DCC on serine, threon... Netrin-1, through its activation of DCC, triggers TRPC chann... Netrin-1-DCC mediated signaling rapidly phosphorylates PLCga... Netrins are secreted proteins that play a crucial role in ne... Neurofascin and NrCAM proteins undergo heterophilic interact... Neurofascin is an L1 family immunoglobulin cell adhesion mol... Neurofascin, expressed at the paranodal loop might be the gl... Newly synthesized CTLA4 expressed on the transmembrane assoc... NF-kB is a family of transcription factors that play pivotal... Novel PDGFs both PDGF-CC and PDGF-DD dimers are secreted as ... NrCAM associates with NP2 and is required for Sema3B- and Se... NrCAM is expressed specifically at node of ranvier where it ... NrCAM is the only mammalian L1CAM family member containing a... Numb is thought to be a phosphotyrosine binding (PTB) domain... Oligomerized Bcl10 facilitates the association with MALT1 to... On recruitment to plasma membrane PLC-gamma1 then hydrolyses... Once phosphorylated, SH2-domain containing tyrosine phosphat... Once SLP-76 is recruited to Gads its rapidly phosphorylated ... Optimal activation of T-lymphocytes requires at least two si... Osteopontin (OPN) is expressed by numerous cell types and is... Osteopontin (OPN) provides an adhesive matrix for endothelia... p130Cas (Crk-associated substrate) is an adaptor protein tha... p190RhoGAP complexed with Plexin-B1 stimulates GTP hydrolysi... p38 alpha/beta MAPK is well established as a promyogenic kin... p38 MAPK is activated by phosphorylation in response to CDO-... p38 MAPK plays a fundamental role in the transition of myobl... p90rsk associates with the internalized L1 in the endosomes ... PAK is autophosphorylated at several sites but S-144 flankin... PD-1 delivers inhibitory signals and downregulates antigen r... PDK1 is a Ser/Thr kinase with a N-term kinase domain and a C... PECAM-1 becomes tyrosine-phosphorylated during the platelet ... PECAM-1 is capable of transmitting information into the cell... PECAM-1/CD31 is a member of the immunoglobulin superfamily (... PECAM-mediated adhesion is complex, because it is capable of... PECAM/CD31 is a member of the immunoglobulin superfamily (Ig... Phosphorylated Ezrin can link in microfilaments to the plasm... Phosphorylated tyrosine 925 in the FAT domain of FAK creates... Phosphorylation of the ITAMs by Lck is followed by the recru... Phosphorylation of Tyr397 in FAK triggers the phosphorylatio... PI3K enzyme bound to adaptor protein TRIM, uses phosphatidyl... PI3K enzyme bound to co-stimulatory protein CD28 catalyzes t... PI3K inducibly associates with CD28: the SH2 domains of the ... PI3K's preferred substrate is phosphatidylinositol 4,5-bisph... PI3Ks can be activated by a number of different receptors, i... PIKE-L a brain-specific GTPase selectively associates with U... PIP2 hydrolysis appers to be an important mechanism for netr... PIP2 places Ezrin at the membrane in a location to be phosph... PKC theta is a member of the Ca++ independent and DAG depend... PKC theta localizes at the interface between T cells and ant... Platelet releasate contains a range of proteins that do not ... PLC-gamma1 interacts with its SH2 domain to the pY132 residu... PLC-gamma1 plays an important role in transducing the extern... Plexin-A's are GAPs for the Ras family GTPase R-Ras. On stim... Plexin-A1 is a receptor for the transmembrane semaphorin, Se... Plexin-B1 activates RhoA and induces growth cone collapse an... Plexin-B1 can mediate inhibition of RhoA via the Sema4D-depe... Plexin-B1 functions as an R-Ras GTPase-activating protein (G... Plexin-bound Rac1 binds to and stimulates the kinase activit... PlexinA1 and A2 are constitutively bound to the src family t... Prion protein (PrP) is a GPI-anchored protein predominately ... Prior to T cell receptor (TCR) stimulation, CD4/CD8 associat... Proton-coupled monocarboxylate transporters (MCT) MCT1, MCT3... PTEN dephosphorylates 3' position of PIP3 to generate PIP2 a... Raft localized PKC theta is further phosphorylated and activ... Receptor tyrosine kinase activation and signaling are typica... Release of Csk from alphaIIbbeta3-c-Src complex recruits PTP... Repulsive Sema4D-Plexin-B1 signaling involves four GTPases, ... Rho family GTPases including Rac, Rho, and Cdc42 are ideal c... Rho GEF's DOCK180 and Trio directly associate with DCC, acti... RhoGEF complexed with Netrin-1-DCC induces guanine nucleotid... Rnd1 is constitutively active and stably associates with Ple... Robo3 antagonizes Robo1/Robo2 function to prevent their resp... Sema3A also mediates integrin inhibition by a mechanism invo... Sema3A binding to Neuropilin-1:Plexin-A complex results in c... Sema3A, a prototypical semaphorin, acts as a chemorepellent ... Sema3A-mediated dissociation of FARP2 from Plexin-A is follo... Sema3E directly binds Plexin-D1. This interaction provides g... Sema4A binds plexinD1 to inhibit angiogenesis. Sema4A–plexin... SEMA4D also associates with CD45, a cell surface protein tyr... Sema4D binds Plexin-B1 to induce repulsive or attractive eff... Sema4D binds Plexin-B1 to induce repulsive or attractive eff... Sema4D-mediated attraction of endothelial cells requires Rho... Sema5s have been implicated in invasive growth, vascular pat... Sema6A binds plexinA2 and plexinA4 to establish lamina-restr... Sema7A has a RGD-motif in the extracellular region and inter... Sema7A signals through two unrelated receptors, an RGD-depen... Semaphorin 4D (Sema 4D/CD100) is an axon guidance molecule w... Semaphorins are a large family of cell surface and secreted ... SH3-mediated binding of p130Cas to FAK is linked to enhanced... ShcA, an SH2-containing adapter protein, acts as a scaffold ... Shootin-1 acts as a linker protein, binding L1 to moving act... Shp2 interact with Tyr816 in the juxtamembrane region and Ty... Shp2 is recruited to the phosphorylated Unc5C receptor after... Siah-1 binds DCC and promotes its proteolysis via the ubiqui... Siah-2 binds to the DCC protein and promote its proteolysis ... Signals from agonist receptors (such as GPVI) trigger the pr... Slit 2 and both its natural cleavage products bind glypican ... Slit stimulation recruits SH3 SH2 adaptor protein Dreadlocks... SLP-76 is an adaptor protein that links proximal and distal ... Sodium-channel proteins in the mammalian brain are composed ... Son of sevenless protein homolog 1(SOS) is an activating nuc... Sos bound to Dock/Nck, with its Rac GEF activity activates R... SOS is the guanine nucleotide exchange factor (GEF) for Ras.... Sos-1 bound to Grb2:Tie2 complex promotes the exchange of in... srGAP bound to Robo's cytoplasmic tail increase the intrinsi... Stromal fibroblasts secrete multiple matrix metalloproteinas... Syntenin-1 is an intracellular binding partner of neurofasci... Talin is one of the major cytoskeletal proteins involved in ... TCR stimulation induce the transient dephosphorylation of PA... Tenascin, an extracellular matrix protein acts as a ligand t... The activated PLC-gamma1 detaches from its substrate LAT and... The activated PLC-gamma1 detaches from its substrate SLP-76 ... The adaptor molecule LAT (Linker for the Activation of T cel... The adaptor protein Nck-1 binds to DCC and recruits Rac-1, C... The ADD domain of DCC binds DCC-interacting 13alpha (DIP13al... The ADD domain of DCC complexed with DIP13alpha interacts wi... The alpha1/beta1 integrin, also known as very late antigen (... The alpha3beta1 integrin is localized in cell-cell junctions... The autophosphorylated, active Lck is now proximally positio... The B and T lymphocyte attenuator, BTLA, is one of the co-in... The best characterized receptors for mediating semaphorin si... The binding of CD4/CD8 to non-polymorphic regions of MHC bri... The carboxy (C) terminal domain of FADK1 interacts with the ... The co-localization of FAK with integrins in focal adhesions... The COOH termini of all ERM proteins have sequence motifs th... The cytoplasmic domain of PD-1 has two tyrosine motifs, ITIM... The cytoplasmic domains of neurofascin contains a highly con... The cytoplasmic tail of BTLA contains three tyrosine residue... The cytoplasmic tails of plexins have two domains, C1 and C2... The DCC family includes DCC and neogenin in vertebrates. DCC... The DCC-caspase activating complex activates caspase-3 throu... The dimerization of Tie2 leads to autophosphorylation and ac... The dual phosphorylated ITAMs recruit Syk kinase ZAP-70 via ... The extracellular matrix (ECM) is a network of macro-molecul... The family of transcription factors myocyte enhancer factor-... The fibrinogen bound alphaIIbbeta3 clusters the platelets to... The full length Slit proteins are membrane bound via the ext... The guanine nucleotide exchange factor SOS interacts with GR... The highly conserved FIGQY motif in the cytoplasmic domain o... The homophilic NCAM1:NCAM1 interaction redistributes these m... The IkB kinase (IKK) complex serves as the master regulator ... The interaction between talin and alphaIIbbeta3 chains break... The interaction of CD28 with its ligands, B7-1 (CD80) and B7... The L1 family of cell adhesion molecules (L1CAMs) are a subf... The levels of second messengers such as Ca+2, cAMP and cGMP ... The long splice version of the PDGF-A chain as well as the C... The major ligands for Tie2 are Ang1 and Ang2. Ang1 has been ... The neural cell adhesion molecule, NCAM, is a member of the ... The neural cell adhesion molecule, NCAM1 is generally consid... The neurotrophin receptor-interacting melanoma-associated an... The NgCAM-related cell adhesion molecule (NrCAM) is member o... The overall shape of integrins is that of a globular ‘head’ ... The p85 subunit of phosphatidylinositol 3-kinase (PI3-kinase... The p85 unit of PI3K is the only signaling molecule identifi... The phosphorylation of CRMPs at Ser522 allows the subsequent... The phosphorylation of two tandem tyrosine residues (Y663 an... The presence of both SH2 and SH3 domains in Crk proteins is ... The Programmed cell death protein 1 (PD-1) is functionally s... The Programmed cell death protein 1 (PD-1) is one of the neg... The recruitment of FAK to c-Src leads to the efficient tyros... The released fragment of Unc5B with death domain interacts w... The RhoGEFs LARG and PDZ-RhoGEF complexed with Plexin-B1 sti... The Robo1 receptor regulates Rho GTPase activity through a l... The Roundabout (Robo) family encodes transmembrane receptors... The sequence around Y226 in the BTLA cytoplasmic domain is a... The Slit family consists of three members that are all expre... The small GTPase p21Rac1 is one of the important targets of ... The TCR is a multisubunit complex that consists of clonotypi... The Tie2/Tek receptor tyrosine kinase plays a pivotal role i... The Tyr420 residue located in the activation loop of Fyn is ... The tyrosine based sorting motif (YRSLE) in L1CD is required... The UNC5H family of netrin-1 receptors also contain death do... The UNC5H netrin1 receptors also contain death domains in th... Three tyrosine residues at positions 771, 783 and 1254 in PL... Thrombospondin-1 (TSP-1) secreated from platelet alpha granu... Thrombospondin-1 (TSP1) is an extracellular matrix glycoprot... Tie receptors and their angiopoietin ligands play a critical... Tie2/Tek provide mitogenic signals to endothelial cells by p... TRAF6 possesses ubiquitin ligase activity and undergoes K-63... TRAF6, which plays central role in innate immune responses, ... Ubiquitinated TRAF6 recruits TAB2 and activates the TAB2-ass... Unc-115/AbLIM is a key regulator of lamellipodia and filopod... UNC-5 receptors interact with netrins and mediate the short-... UNC-5 uses DCC as a co-receptor and binds to the DCC P1 doma... Unc5 netrin receptors mediate repellent responses to netrin.... Upon interaction with CARMA1, Bcl10 undergoes phosphorylatio... Upon Slit stimulation Sos is recruited into the multiprotein... Upon TCR-CTLA-4 complex formation, CTLA4 is tyrosine phospho... Upon the production of activated Rap1A at the plasma membran... Vav1 exists in an auto-inhibitory state folded in such a way... Vav1 protein is a cytoplasmic guanine nucleotide exchange fa... Vav1 serves as a GEF for Cdc42-GTPase. It interacts with and... Vav1, once activated by PIP3 binding and phosphorylation by ... Vilse and its human homolog bind directly to the intracellul... Vilse/CrossGAP (CrGAP) a conserved Rac-Specific GAP in Droso... When CTLA4 is engaged by B7 molecules, PP2A disassociates fr... When Netrin-1 binds to the DCC-NCK1 complex, a conformationa... While HNK-1 (human natural killer 1) carbohydrate is express...
Author of entries
'NCAM-1:ATP [plasma membrane]' negatively regulates 'NCAM1 binds FGFR-1' /figures/CD28_interaction.png /figures/CD28_PI3K.png /figures/CD28_Vav1.jpg /figures/integrinsScreen.jpg /figures/midline.png /figures/NCAM1.png /figures/pCD28.png /figures/PDGF_interactions.jpg /figures/PDGF_specificity.jpg /figures/sema3A1.png /figures/sema3A2.png /figures/sema4D1.png /figures/sema4D2.png /figures/slit_robo.png /figures/TCR_1.jpg /figures/TCR_2.jpg /figures/TCR_3.jpg /figures/TCR_4.jpg /figures/TCR_5.jpg 78 kDa glucose-regulated protein [endoplasmic reticulum membrane] U K E G B C d O O R H U R 78 kDa glucose-regulated protein [extracellular region] U K E G B C d O O R H U R 78 kDa glucose-regulated protein precursor [endoplasmic reticulum lumen] U K E G B C d R H R 78 kDa glucose-regulated protein precursor [extracellular region] U K E G B C d R H R _Ang1 [extracellular region] U K E G B C d R H R P P _Tie2 [plasma membrane] U E Abl tyrosine kinases [cytosol] ABL1 [cytosol] U K E G B C d O O R H U R P P P P P P P P P P P P P D D D D D ABL1 [cytosol] U K E G B C d R H R P P P P P P P ABL1:CDO:JLP [plasma membrane] ABL1:JLP:CDO complex [plasma membrane] Abl:pRobo1:slit2:Glypican-1 [plasma membrane] Abl:Robo1:Slit2:Glypican-1 [plasma membrane] Abl:Robo:Slit [plasma membrane] ABL_DROME [cytosol] U E G B C d F R ABLIM [cytosol] Actin-binding LIM protein 1 [cytosol] U K E G B C d O R H U R Actin-binding LIM protein 2 [cytosol] U K E U P P Actin-binding LIM protein 3 [cytosol] U K E G B C d R H U R P Activated CARMA1 [plasma membrane] Activated PLC gamma1 bound to PIP2 [plasma membrane] Activated Rac-1 and Cdc42 [cytosol] Activated TRP channels [plasma membrane] Activated xtrpc1 [plasma membrane] U K Activated ZAP-70 [plasma membrane] Activation of caspase-3 [Homo sapiens] Activation of Cdc42 [Homo sapiens] Activation of Cdc42 by pVav1 [Homo sapiens] Activation of Clasp [Drosophila melanogaster, Homo sapiens] Activation of CLASP [Homo sapiens] Activation of Fyn [Mus musculus, Homo sapiens, etc.] Activation of Fyn [Homo sapiens] Activation of IKK complex [Homo sapiens] Activation of Lck [Homo sapiens] Activation of NF-kB complex [Homo sapiens] Activation of p38 alpha/beta MAPK [Mus musculus] Activation of p38 alpha/beta MAPK [Homo sapiens] Activation of PAK by Rac1 [Homo sapiens] Activation of PAK by Rac1 and Cdc42 [Homo sapiens] Activation of Rac [Homo sapiens] Activation of Rac by Sos [Homo sapiens] Activation of Rac by Sos [Drosophila melanogaster] Activation of Rac1 [Homo sapiens] Activation of Rac1 by FARP2 [Mus musculus] Activation of Rac1 by FARP2 [Homo sapiens] Activation of Rac1 by pVav1 [Homo sapiens] Activation of Rac1 by VAV2 [Homo sapiens] Activation of Rap1 [Homo sapiens] Activation of Rho by LARG and PDZ-RhoGEF [Homo sapiens] Activation of Src [Homo sapiens] Activation of TAK1-TAB2 complex [Homo sapiens] Activation of Talin [Homo sapiens] Activation of TRPC channels by Netrin-1 [Homo sapiens] Activation of TRPC channels by Netrin-1 [Xenopus laevis] Activation of Vav1 [Homo sapiens] Activation of ZAP-70 [Homo sapiens] Active c-Src (p-Y419) [cytosol] U K E G B C d O R R H H U R R P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P D D D D D D D D D D D D D D D D D D D D D D D D D D D D D D D D D D D D D D D Active Cdc42 bound to Netrin:DCC complex [plasma membrane] Active LIMK1 [cytosol] Active PDGF dimers (AA, AB, BB) [extracellular region] Active PDGF dimers (CC, DD) [extracellular region] Active phosphorylated PKC theta [plasma membrane] U K E G B C d O R H U R P D Active PKC theta (open conformation) [plasma membrane] U K E G B C d O R H U R P D Active PKC theta bound to DAG [plasma membrane] Active platelet-derived growth factor A chain isoform 2 [extracellular region] U K E G B C d O R H U R Active platelet-derived growth factor A chain isoforms [extracellular region] Active Rac1 bound to Netrin-1-DCC complex [plasma membrane] Active Rac1 interacts with Plexin-B1:Sema4D [Homo sapiens] active TAK1-P [cytosol] U K E G B C d O R H U R P ADAP [cytosol] U E G B C d O R H U R P Adaptor protein complex 2 (AP-2) large adaptins [plasma membrane] Adenylyl cyclase-associated protein 1 [cytosol] U E G B C d R H R Adenylyl cyclase-associated protein 1 [cytosol] U K E G B C d R H U R P Adenylyl cyclase-associated protein 1 [extracellular region] U E G B C d R H R Adenylyl cyclase-associated protein 1 [extracellular region] U K E G B C d R H U R P Agrin [extracellular region] U E Agrin [extracellular region] U K E G B C d O R H U R AKT interacts and phosphorylates Cot [Homo sapiens] Akt:pCot [plasma membrane] Akt:pCot phosphorylates NIK [Homo sapiens] Akt:pCot:pNIK [plasma membrane] ALCAM [plasma membrane] U K E G B C d R H R Alpha 1 Beta 1 Integrin : Collagen IV: Mg++ complex [plasma membrane] Alpha 1 Beta 1 Integrin : Laminin-1:Mg++ complex [plasma membrane] Alpha 10 beta 1 integrin:Collagen type-II: Mg++ complex [plasma membrane] Alpha 11 beta 1 integrin: Collagen type-I:Mg++ complex [plasma membrane] alpha 2-8 polysialyltransferases [Golgi membrane] Alpha 3 Beta 1 Integrin : Laminin-5 complex [plasma membrane] Alpha 3 Beta 1 Integrin : Thrombospondin-1 complex [plasma membrane] Alpha 5 Beta 1 receptor bound to Ostepontin [plasma membrane] Alpha 6 Beta 1 Integrin : Laminin-1 complex [plasma membrane] Alpha 6 Beta 4 Integrin : Laminin-5 complex [plasma membrane] Alpha 7 Beta 1 Integrin : Laminin-1 complex [plasma membrane] Alpha 7 beta 1 integrin: Laminin-2 complex [plasma membrane] Alpha 8 beta 1:Fibronectin complex [plasma membrane] Alpha 8 beta 1:Osteopontin complex [plasma membrane] Alpha 8 beta 1:Tenascin-c complex [plasma membrane] Alpha 9 beta 1:Osteopontin complex [plasma membrane] Alpha 9 beta 1:Tenascin-c complex [plasma membrane] Alpha 9 beta 1:VCAM-1 complex [plasma membrane] Alpha actinins [extracellular region] Alpha actinins [platelet alpha granule lumen] alpha beta tubulin dimer [cytosol] alpha E beta 7:E-cadherin complex [plasma membrane] alpha tubulin -1 [extracellular region] U K E G B C d O R H U R alpha tubulin [cytosol] alpha tubulin:GTP [cytosol] Alpha v beta 1:Fn complex [plasma membrane] Alpha v beta 3:BSP II complex [plasma membrane] Alpha v beta 3:Fn complex [plasma membrane] Alpha v beta 3:Vitronectin complex [plasma membrane] Alpha v beta 5:Vitronectin complex [plasma membrane] Alpha v beta 6:Fn complex [plasma membrane] Alpha v beta 8:Vitronectin complex [plasma membrane] Alpha-actinin 1 [cytosol] U K E G B C d O R H U R Alpha-actinin 1 [extracellular region] U K E G B C d O R H U R Alpha-actinin 1 [platelet alpha granule lumen] U K E G B C d O R H U R Alpha-actinin 2 [extracellular region] U K E G B C d O R H U R P P P Alpha-actinin 2 [platelet alpha granule lumen] U K E G B C d O R H U R P P P Alpha-actinin 4 [extracellular region] U K E G B C d O O R H U R P P alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity of alpha 2-8 polysialyltransferases [Golgi membrane] Alpha-V beta 3:Fibrillin-1 complex [plasma membrane] Alpha-V beta 3:Tenascin complex [plasma membrane] Alpha-V beta 3:vWF complex [plasma membrane] alpha/beta catenin [cytosol] alpha1beta1/alpha2beta1 [plasma membrane] Alpha2beta1 complex with Laminin-5 [plasma membrane] alphaIIbbeta3 activation [Homo sapiens] alphaIIbbeta3 ECM ligands [extracellular region] alphaIIbbeta3:active c-Src pY418 [plasma membrane] alphaIIbbeta3:c-Src clustering [Homo sapiens] alphaIIbbeta3:inactive c-Src pY418, pY529 [plasma membrane] alphaIIbbeta3:inactive c-src pY418, pY529:Csk [plasma membrane] alphaIIbbeta3:inactive c-src:Csk [plasma membrane] AlphaIIbbeta3:talin-RIAM complex:inactive c-src:Csk [plasma membrane] Angiopoietin-1 [extracellular region] U K E G B C d O R H U R Angiopoietin-2 [extracellular region] U K E G B C d O R H U R Angiopoietin-4 [extracellular region] U K E G B C d O R H U R ANK3_RAT [cytosol] U Ankyrin-B [cytosol] U K E O O U Ankyrin-G [cytosol] U K E G B C d O R R H H U R R P Ankyrin-G:Neurofascin [plasma membrane] Ankyrin-R [cytosol] U K E G B C d O R H U R Ankyrins [cytosol] Ankyrins link voltage-gated sodium and potassium channels to spectrin and L1 [Homo sapiens] Ankyrins link voltage-gated sodium and pottasium channels to spectrin and L1 [Rattus norvegicus] Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] Antigen-bearing MHC Class II : TCR complex:CD4:p-Lck(Y505) [plasma membrane] Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] Antigen-bearing MHC Class II: TCR with dephosphorylated CD3 zeta chain:CD4 [plasma membrane] Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] AP-2 complex subunit sigma [plasma membrane] U K E G B C d O R H U R AP2 clathrin:L1:KIF4:microtubule [cytosol] apoA-I [secretory granule] U K E E G B C d O O O O R H U R P P P P P P P Artemin [extracellular region] U K E G B C d O R R H H U R R P P P auto phosphorylated FADK 1 [cytosol] U K E G B C d O R R H H U R R P P P P P P Auto-phosphorylation of FADK1 at Y397 [Homo sapiens] Auto-ubiquitination of TRAF6 [Homo sapiens] Autophosphorylation of c-src [Homo sapiens] Autophosphorylation of NCAM1 bound Fyn [Mus musculus, Homo sapiens] Autophosphorylation of NCAM1 bound Fyn [Homo sapiens] Autophosphorylation of PAK [Homo sapiens] Autophosphorylation of PDGF alpha receptors [Homo sapiens] Autophosphorylation of PDGF alpha/beta receptors [Homo sapiens] Axon guidance [Homo sapiens] Axonin-1 [plasma membrane] U K E G B C d R H R P Axonin-1 [plasma membrane] U K E G B C d O R H U R B7-1 homodimer/ B7-2 [plasma membrane] Basic fibroblast growth factor receptor 1 [plasma membrane] U K E G B C d R R H H R R P Basigin binds CD98 complex [Homo sapiens] Basigin binds Mannose-carrying cell recognition molecules [Homo sapiens] Basigin binds Matrix metalloproteinase-1 [Homo sapiens] Basigin interactions [Homo sapiens] Basigin:CD98hc complex [plasma membrane] Basigin:Mannose-carrying cell recognition molecules [plasma membrane] Basigin:MMP1 [plasma membrane] Bcl10 [cytosol] U K E G G B B C C d d O R H U R Bcl10 bound to CARMA1 [plasma membrane] Bcl10 trimer bound to CARMA1 trimer [plasma membrane] Beta 1 subunit of VGCC [plasma membrane] U K E G B C d O R H U R R Beta 2 subunit of VGCC [plasma membrane] U E G B C d O R H U R Beta 3 subunit of VGCC [plasma membrane] U K E G B C d O R H U R Beta 4 subunit of VGCC [plasma membrane] U K E G B C d O O O R R H H U R R P Beta actin:ATP [cytosol] Beta actin_Rat [cytosol] U K E G B C d R H R beta tubulin [cytosol] beta tubulin:GTP [cytosol] beta1 integrins [plasma membrane] Bnip2 interacts with CDO complex [Homo sapiens] Bnip2 interacts with CDO complex [Mus musculus] BNIP2_MOUSE [cytosol] U E G B C d R H R BOC_MOUSE [plasma membrane] U K E G B C d R H R P P Bone sialoprotein 2 [extracellular region] U K E G B C d O R H U R Bromodomain and PHD finger-containing protein 3 [cytosol] U K E G B C d R H U R Bromodomain and PHD finger-containing protein 3 [extracellular region] U K E G B C d R H U R BTLA interacts with HVEM [Homo sapiens] BTLA-HVEM complex [plasma membrane] Cadherin-catenin:CDO:BOC:Bnip2 [plasma membrane] Cadherin-catenin:CDO:BOC:Bnip2:CDC42-GTP [plasma membrane] Cadherin-catenin:JLP:CDO:BOC:Bnip2-Cdc42 [plasma membrane] Cadherin:Catenin [plasma membrane] Calmodulin [extracellular region] U K K E E E G G G B B B C C C d d d O O O R R R H H H U R R R P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P Calumenin [endoplasmic reticulum lumen] U K E G B C d O R H U R Calumenin [endoplasmic reticulum lumen] U K E G B C d R H R Calumenin [extracellular region] U K E G B C d R H R Calumenin [extracellular region] U K E G B C d O R H U R CAP [cytosol] CAP2 [cytosol] U K E G B C d R H U R CAP:Abl:Robo1:Slit2:Glypican-1 [plasma membrane] CAPT:Abl:Robo:Slit [plasma membrane] CAPT_DROME [cytosol] U K E G B C d F R R CARMA1 [cytosol] U K E G B C d O R H U R CARMA1 bound to PDK1 [plasma membrane] CARMA1 trimer [plasma membrane] Caspase cleavage of DCC [Homo sapiens] Caspase cleavage of UNC5A [Homo sapiens] Caspase cleavage of UNC5B [Homo sapiens] Caspase cleavage of Unc5h1 [Mus musculus] Caspase cleavage of Unc5h2 [Mus musculus] Caspase-9 binds DCC:DIP13alpha complex [Homo sapiens] Catenin alpha-2 [cytosol] U K U Catenin beta-1 [cytosol] U K E G B C d O O O R R R H H H U R R R P P P P P P P P P P CD28 bound PI3K phosphorylates PIP2 to PIP3 [Homo sapiens] CD28 bound to B7 ligands [plasma membrane] CD28 co-stimulation [Homo sapiens] CD28 dependent PI3K/Akt signaling [Homo sapiens] CD28 dependent Vav1 pathway [Homo sapiens] CD28 homodimer binds B7-1 homodimer [Homo sapiens] CD28 homodimer binds B7-2 monomer [Homo sapiens] CD28:B7-1 [plasma membrane] CD28:B7-2 [plasma membrane] CD28:Gads [plasma membrane] CD28:Grb2 [plasma membrane] CD28:PI3K [plasma membrane] CD3 delta with phosphorylated ITAMs [plasma membrane] U K E G B C d O O R H U R P CD3 epsilon with phosphorylated ITAM [plasma membrane] U K E G B C d O R H U R P P P CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] CD3 epsilon: CD3 gamma with phosphorylated ITAM [plasma membrane] CD3 gamma with phosphorylated ITAM [plasma membrane] U K E G B C d O R H U R P CD3 zeta dimer with phosphorylated ITAMs [plasma membrane] CD3 zeta with phosphorylated ITAMs [plasma membrane] U K E G B C d O O R H U R P P CD98hc complex [plasma membrane] CDC42-GDP [cytosol] CDC42-GTP [cytosol] CDC42_MOUSE [cytosol] U K E Cdk5 [cytosol] U K E G B C d R H R Cdk5 phosphorylated CRMP's 1-5 [cytosol] Cdk5:p35 [cytosol] CDO binds BOC [Homo sapiens] CDO binds promyogenic cadherins [Homo sapiens] CDO in myogenesis [Homo sapiens] CDO1_MOUSE [plasma membrane] U K E G B C d R H R P CDO:BOC [plasma membrane] CDO:BOC:Bnip2:CDC42-GTP [plasma membrane] CDO:BOC:Bnip2_Mouse [plasma membrane] CDO:BOC:Neogenin:Netrin-3 [plasma membrane] CDO:BOC:Neogenin:Netrin-3 [plasma membrane] CDO:BOC:Trans-cadherin homodimer:catenin [plasma membrane] CDO:BOC_Mouse [plasma membrane] Change of PKC theta conformation [Homo sapiens] CHL1 [plasma membrane] U K E O U CHL1 interactions [Homo sapiens] CHL1 interacts with Ankyrin-G [Homo sapiens] CHL1 interacts with Ankyrin-G [Mus musculus, Rattus norvegicus] CHL1 interacts with beta1 integrins [Homo sapiens] CHL1 interacts with beta1 integrins [Mus musculus] CHL1 interacts with contactin-6 [Mus musculus] CHL1 interacts with contactin-6 [Homo sapiens] CHL1 interacts with Hsc70 [Homo sapiens] CHL1 interacts with Hsc70 [Mus musculus] CHL1 interacts with NP-1 [Homo sapiens] CHL1 interacts with NP-1 [Mus musculus] CHL1:alpha1beta1/alpha2beta1 integrins [plasma membrane] CHL1:Ankyrin-G [plasma membrane] CHL1:Ankyrin-G [plasma membrane] CHL1:beta1 integrins [plasma membrane] CHL1:CNTN6 [plasma membrane] CHL1:CNTN6 [plasma membrane] CHL1:Hsc70 [plasma membrane] CHL1:Hsc70 [plasma membrane] CHL1:NP-1 [plasma membrane] CHL1:NP-1 [plasma membrane] CHL1_MOUSE [plasma membrane] U K E Cis-heterodimerization of L1 and Axonin-1 [Homo sapiens] Cis-heterodimerization of L1 and Contactin-1/F3/F11 [Homo sapiens] Cis-heterodimerization of L1 and DM-GRASP/ALCAM/BEN [Homo sapiens] Cis-heterodimerization of NgCAM and Axonin-1 [Gallus gallus] Cis-heterodimerization of NgCAM and Contactin-1/F3/F11 [Gallus gallus] Cis-heterodimerization of NgCAM and DM-GRASP/ALCAM [Gallus gallus] CLASP [cytosol] Clasp:Abl:Robo1:Slit2:Glypican-1 [plasma membrane] CLASP:Abl:Robo:Slit [plasma membrane] Cleaved classical PDGF peptides [Golgi membrane] Cleaved fragment of PDGF A-chain isoform 2 [Golgi membrane] U K E G B C d O R H U R Cleaved fragment of PDGF B-chain (191-241) [Golgi membrane] U K E G B C d O O R H U R P Cleaved fragment of PDGF B-chain [Golgi membrane] U K E G B C d O O R H U R P Cleaved fragment of PDGF chain C [extracellular region] U K E G B C d R H U R Cleaved fragment of PDGF chain D [extracellular region] U K E G B C d O R H U R Cleaved fragment of PDGF, A chain isoform 1 [Golgi membrane] U K E G B C d O R H U R Cleaved fragments of PDGF A chain isoforms [Golgi membrane] Cleaved novel PDGF fragments [extracellular region] Clusterin [extracellular region] U E G B C d O R R H H U R R Clusterin [platelet alpha granule lumen] U E G B C d O R R H H U R R CNTN1 [plasma membrane] U K E G B C d O R H U R CNTN1_CHICK [plasma membrane] U K E G B C d R H CNTN6_MOUSE [plasma membrane] U K E G B C d R H R Cofilin-1 [cytosol] U K E G G B B C C d d R H R Cofilin-1 [cytosol] U K E G B C d O R H U R P P Cofilin-1 [extracellular region] U K E G B C d O R H U R P P Cofilin-1 [extracellular region] U K E G G B B C C d d R H R Collagen alpha 1(IV) chain [extracellular region] U K E G B C d O O O R H U R P Collagen alpha 3(VI)/5(VI)/6(VI) [extracellular region] Collagen alpha I(II) [extracellular region] U K E G B C d O O O O O O O O O O O O U R P P Collagen alpha-1 [extracellular region] U K E G B C d O O O R H U R Collagen alpha-1 [extracellular region] U K E G B C d O R H U R Collagen alpha-1 [extracellular region] U K E G B C d O O O R H U R P P Collagen alpha-1(IV):Collagen alpha-2(IV) [extracellular region] Collagen alpha-1(VI) chain [extracellular region] U K E G B C d O O R H U R Collagen alpha-2 [extracellular region] U K E G B C d O O O R H U R P Collagen alpha-2 [extracellular region] U K E G B C d O O O R H U R Collagen alpha-2(IV) chain [extracellular region] U K E G B C d O R H U R P Collagen alpha-2(VI) chain [extracellular region] U K E G B C d O O O R H U R Collagen alpha-3 [extracellular region] U K E G B C d O O R H U R Collagen alpha-3(IV):Collagen alpha-4(IV):Collagen alpha-5(IV) triple helix [extracellular region] Collagen alpha-3(VI) chain [extracellular region] U K E G B C d O O O R H U R P P P P Collagen alpha-4(IV) chain [extracellular region] U K E G B C d O O O R H U R Collagen alpha-5(IV) chain [extracellular region] U K E G B C d O O O R H U R Collagen alpha-5(VI) chain [extracellular region] U K U Collagen alpha-6(VI) chain [extracellular region] U K U Collagen type-II [extracellular region] Collagen-I type III [extracellular region] Collagen-I type IX [extracellular region] Collagen-I type V [extracellular region] Collagens [extracellular region] Complex of Tie2:Ang-1 [plasma membrane] Complex of Tie2:Ang-1 [plasma membrane] Complex of Tie2:Ang2 [plasma membrane] Contactin-1 [plasma membrane] U K E G B C d R H R Contactin-1:CASPR complex [plasma membrane] Contactin-6 [plasma membrane] U K E G B C d O R H U R Contactin-associated protein 1 [plasma membrane] U K E G B C d R H R Contactin-associated protein 1 [plasma membrane] U K E G B C d O R H U R Contactin1:CASPR complex [plasma membrane] Costimulation by the CD28 family [Homo sapiens] Crk binding to p130cas [Homo sapiens] Crk binds to the active PDGF receptor [Homo sapiens] Crk bound to p130Cas:FADK1 [plasma membrane] Crk isoforms [cytosol] Crk-I [cytosol] U K E G B C d O R R H H U R R P P P P P P CRMP's 1-5 [cytosol] CRMP's tetramers [cytosol] CRMP-2 [cytosol] U K E G B C d O R H U R CRMP-2:NUMB:alpha adaptin [plasma membrane] CRMPs in Sema3A signaling [Homo sapiens] Csk:p-PAG [plasma membrane] CTLA-4 binds B7-1/B7-2 [Homo sapiens] CTLA-4:PP2A [plasma membrane] CTLA4 inhibitory signaling [Homo sapiens] cysteine-type endopeptidase activity of DCC:DIP13alpha:Caspase-9 [plasma membrane] cysteine-type endopeptidase activity of unidentified caspase [cytosol] DAP12:TRIM2 complex [plasma membrane] DAPK binds UNC5B [Homo sapiens] DAPK binds Unc5h2 [Mus musculus] DAPKs [cytosol] DAPKs [cytosol] DCC [plasma membrane] U K E G B C d R H R DCC bound to UNC-5:Netrin-1 [plasma membrane] DCC heterodimerizes with UNC-5:Netrin-1 [Homo sapiens] DCC heterodimerizes with Unc-5:Netrin-1 [Mus musculus, Rattus norvegicus] DCC interacting NCK-1 [Homo sapiens] DCC interaction with Ezrin [Homo sapiens] DCC interaction with Netrin-1 [Homo sapiens] DCC interaction with ROBO-1 [Homo sapiens] DCC interaction with Robo-1 [Drosophila melanogaster] DCC interaction with SIAH1 [Homo sapiens] DCC interaction with SIAH2 [Homo sapiens] DCC interacts with DIP13alpha [Homo sapiens] DCC mediated attractive signaling [Homo sapiens] DCC&UNC5A:Netrin-4 [plasma membrane] DCC's fragment with the ADD domain [plasma membrane] U K E G B C d O R H U R DCC's inhibitory C-terminal domain [cytosol] U K E G B C d O R H U R DCC-interacting protein 13-alpha [endosome membrane] U K E G B C d O R H U R DCC/Neogenin [plasma membrane] DCC/Neogenin [plasma membrane] DCC/UNC5A [plasma membrane] DCC:DIP13alpha [plasma membrane] DCC:DIP13alpha:Caspase-9 [plasma membrane] DCC:Ezrin complex [plasma membrane] DCC:Netrin-1 [plasma membrane] DCC:Robo:Slit [plasma membrane] DCC:Robo:Slit [plasma membrane] DCC_MOUSE [plasma membrane] U E G B C d R H R Death-associated protein kinase 1 [cytosol] U K E G B C d R R H H R R Death-associated protein kinase 1 [cytosol] U K E G B C d O R H U R P P P P P P P P P P Death-associated protein kinase 2 [cytosol] U K E G B C d R H R Death-associated protein kinase 2 [cytosol] U K E G B C d R H U R P P P P P Death-associated protein kinase 3 [cytosol] U K E G B C d R H R Death-associated protein kinase 3 [cytosol] U K E G B C d O R H U R P P D Dephosphorylation of AKT by PP2A [Homo sapiens] Dephosphorylation of CD3-zeta by PD-1 bound phosphatases [Homo sapiens] Dephosphorylation of inactive c-src by PTPB1 [Homo sapiens] Dephosphorylation of Lck-pY505 by CD45 [Homo sapiens] Dephosphorylation of NCAM1 bound pFyn [Homo sapiens] Dephosphorylation of NCAM1 bound pFyn [Homo sapiens, Mus musculus] Dephosphorylation of pL1 (Y1176) [Homo sapiens] Dihydropyrimidinase-related protein 1 (CRMP-1) [cytosol] U E G B C d O R H U R Dihydropyrimidinase-related protein 3 (CRMP-4) [cytosol] U K E G B C d O R H U R Dihydropyrimidinase-related protein 4 (CRMP-3) [cytosol] U K E G B C d O R H U R Dihydropyrimidinase-related protein 5 (CRAM) [cytosol] U K E G B C d O R H U R Dimerization of LIMK1 by Hsp90 [Homo sapiens] Dimerization of Tie2/Ang1 complex [Homo sapiens] Disassociation of PLC-gamma1 from LAT [Homo sapiens] Disassociation of PLC-gamma1 from SLP-76 [Homo sapiens] Dock [cytosol] U E G B C d F R R R Dock binds Robo:Slit [Drosophila melanogaster] DOCK180 [cytosol] U K E G B C d O R H U R Docking protein 2 [cytosol] U K E G B C d O R H U R P Doublecortin [cytosol] U K E G B C d O O R H U R R R P P Doublecortin binds phosphorylated neurofascin [Homo sapiens, Rattus norvegicus] Doublecortin binds phosphorylated neurofascin [Homo sapiens] Downstream TCR signaling [Homo sapiens] Dynamin-1/2/3 [plasma membrane] Dynamin-3 [plasma membrane] U K E U E12 [nucleoplasm] U E E12/E47 [nucleoplasm] E12/E47 [nucleoplasm] E2-2/ITF-2 [nucleoplasm] U K E G B C d O R H U R E3 ubiquitin-protein ligase SIAH1 [cytosol] U K E G B C d O R R H H U R R P ECM ligands: alphaIIbbeta3:phospho c-Src:phosphorylated FADK1:Talin complex [plasma membrane] ECM ligands: alphaIIbbeta3:phspho c-src:phospho FADK1: Talin complex [plasma membrane] ECM ligands:2(alphaIIbbeta3:active c-src):Talin complex [plasma membrane] ECM ligands:alphaIIbbeta3:c-src:FADK1:Talin complex [plasma membrane] ENA [cytosol] U K E G B C d F R Ena/VASP binds Robo1:Slit2 complex [Homo sapiens] Ena/VASP binds Robo1:Slit2 complex [Drosophila melanogaster] Ena/Vasp proteins [cytosol] ENAH [cytosol] U K E G B C d O R H U R EPHB2 [plasma membrane] U K E O O O R H U P P EPHB2_CHICK [plasma membrane] U K E P ERM [cytosol] ERM [cytosol] ERM:PIP2 [plasma membrane] ERM:PIP2 [plasma membrane] EVL [cytosol] U K E G B C d R H U R Exocytosis of Proactivator polypeptide [Homo sapiens] Exportin-5 [cytosol] U K E G B C d O R H U R Exportin-5 [nucleoplasm] U K E G B C d O R H U R Extracellular matrix ligands [extracellular region] Extracellular processing of novel PDGFs [Homo sapiens] EZRI_RAT [cytosol] U K E G B C d R H R Ezrin [cytosol] U K E G B C d O R H U R P Ezrin:PIP2 [plasma membrane] F-beta actin [cytosol] factor XIII A chain [platelet alpha granule lumen] U K E G B C d O R H U R P P P P P P P P D D FADK1 interaction with DCC [Homo sapiens] FADK1 interaction with DCC [Mus musculus] FADK1:DCC oligomer:Netrin [plasma membrane] FAK-SRC complex [plasma membrane] FARP2 [cytosol] U K E G B C d R H R FARP2 [cytosol] U K E G B C d R H U R FARP2:PIP5KIgamma [cytosol] FceRI gamma dimer [plasma membrane] FDAK1 bound p130Cas complex [plasma membrane] Fes [cytosol] U K E G B C d R H R FES [cytosol] U E G B C d O R H U R P P Fes phosphorylated CRMP's 1-5 [cytosol] FGFR-1 homodimer [plasma membrane] Fibrillin-1 [extracellular region] U K E G B C d O O O O O O R H U R P P P P P P P P Fibronectin dimer [extracellular region] Filamin-A [cytosol] U K E O O O O O O O O O U P P P D Filamin-A [extracellular region] U K E O O O O O O O O O U P P P D Focal adhesion kinase 1 [cytosol] U K E P P P Focal complex [plasma membrane] Formation of clathrin coated vesicle [Homo sapiens] Frazzled [plasma membrane] U E G B C d F R Fructose-bisphosphate aldolase A [extracellular region] U K E G B C d O R R R H