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Hydrolysis of PIP3 to PIP2 Stable identifier REACT_12545.1 Authored Rudd, C.E., de Bono, B, Garapati, P V, 2008-01-24 Reviewed Trowsdale, J, 2008-02-26 Your feedback Let us know what you think of this article (click here) PTEN dephosphorylates 3' position of PIP3 to generate PIP2 and negatively regulates the PI3K pathway and PKB activation. Input (present at start of reaction) Phosphatidylinositol-3,4,5-trisphosphate [plasma membrane] CC Output (present at end of reaction) Phosphatidylinositol-4,5-bisphosphate [plasma membrane] CC pyrophosphate [cytosol] CCP Catalyst PTEN (Mg2+ cofactor) [cytosol] GO molecular function phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity GO Preceding event(s) PI3K phosphorylates PIP2 to PIP3 [Homo sapiens] Organism Homo sapiens Cellular compartment plasma membrane GO Equivalent event(s) in other organism(s) Hydrolysis of PIP3 to PIP2 [Canis familiaris] Hydrolysis of PIP3 to PIP2 [Bos taurus] Hydrolysis of PIP3 to PIP2 [Sus scrofa] Hydrolysis of PIP3 to PIP2 [Mus musculus] Hydrolysis of PIP3 to PIP2 [Rattus norvegicus] Hydrolysis of PIP3 to PIP2 [Gallus gallus] Hydrolysis of PIP3 to PIP2 [Taeniopygia guttata] Hydrolysis of PIP3 to PIP2 [Xenopus tropicalis] Hydrolysis of PIP3 to PIP2 [Danio rerio] Hydrolysis of PIP3 to PIP2 [Drosophila melanogaster] Hydrolysis of PIP3 to PIP2 [Caenorhabditis elegans] Hydrolysis of PIP3 to PIP2 [Arabidopsis thaliana] Hydrolysis of PIP3 to PIP2 [Oryza sativa] Hydrolysis of PIP3 to PIP2 [Dictyostelium discoideum] Participating molecules Magnesium [cytosol] CCP Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase PTEN [cytosol] UKEGGBBCCddOOOOOOOOOORHURP Phosphatidylinositol-3,4,5-trisphosphate [plasma membrane] CC Phosphatidylinositol-4,5-bisphosphate [plasma membrane] CC pyrophosphate [cytosol] CCP