Reactome: PI3K-p110 [cytosol]

Details

Participates in processes
Name	PI3K-p110 Phosphatidylinositol 3-kinase catalytic subunit, alpha isoform (EC 2.7.1.137) (PI3-kinase p110 subunit alpha) (PtdIns-3-kinase p110) (PI3K) Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, alpha isoform PI3-kinase p110 subunit alpha PtdIns- 3-kinase p110
Stable identifier	REACT_5298.2
Links to corresponding entries in other databases	BioGPS Gene:5290 CTD Gene:5290 ENSEMBL:ENSG00000121879 Entrez Gene:5290 HapMap:NM_006218 KEGG Gene:5290 OMIM:114480 OMIM:114500 OMIM:171834 OMIM:604370 RefSeq:NM_006218 RefSeq:NP_006209 UCSC human:P42336 UniProt:P42336 dbSNP Gene:5290
Other identifiers related to this sequence	PK3CA_HUMAN, Q14CW1, Q99762, ENSG00000121879, ENST00000263967, ENSP00000263967, 204369_at, 40704_at, Z29090_at, g5453891_3p_at, A_14_P127878, A_14_P108238, A_14_P113684, A_14_P128410, A_23_P92057, GE60386, AB210020, Z29090, U79143, BC113601, BC113603, EntrezGene:5290, GI_5453891-S, ILMN_26220, ILMN_32804, IPI00031386, MIM:171834, MIM:114480, MIM:114500, MIM:604370, BAE06102, CAA82333, AAB39753, AAI13602, AAI13604, NM_006218, NP_006209, Hs.85701, Q4LE51, P42336, Q4LE51_HUMAN, PK3CA_HUMAN, IPR000403, IPR000341, IPR001263, IPR002420, IPR003113
Reference entity	UniProt:P42336 PIK3CA
Cellular compartment	cytosol GO
Organism	Homo sapiens
Is represented by generalisation(s)	PI3K-catalytic subunit [cytosol]
Component of	EGF:Phospho-EGFR-GRB2:GAB1:PI3Kreg:PI3Kcat [cytosol] PI3K alpha [cytosol] Activated Rac1:PI3K alpha [cytosol] CD28:PI3K [plasma membrane] ICOS:PI3K [plasma membrane] G-protein alpha (q/11):PI3K alpha [plasma membrane] PI3K [cytosol] phospho-IRS:PI3K [cytosol] PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] Activated FGFR bound to PI3K [plasma membrane] ... List all 14 items
Signaling by GPCR - GPCR downstream signaling - G alpha (q) signalling events - G alpha (q) inhibits PI3K alpha [Homo sapiens] - G alpha (12/13) signalling events - Rac1 activation of PI3K [Homo sapiens] Signaling in Immune system - TCR signaling - Downstream TCR signaling - Recruitment of PI3K to plasmamembrane [Homo sapiens] - PI3K phosphorylates PIP2 to PIP3 [Homo sapiens] - Costimulation by the CD28 family - CD28 co-stimulation - CD28 dependent PI3K/Akt signaling - PI3K binds CD28 [Homo sapiens] - CD28 bound PI3K phosphorylates PIP2 to PIP3 [Homo sapiens] - PI3K binds ICOS [Homo sapiens] Signaling by EGFR - Gab1 signalosome - PI3K catalytic subunit binds to Gab1:Grb2:PI3K:EGF:EGFR [Homo sapiens] - PI3K converts Phosphatidylinositol-4,5-bisphosphate to Phosphatidylinositol-3,4,5-trisphosphate [Homo sapiens] Hemostasis - Formation of Platelet plug - Platelet Activation - Platelet activation triggers - GPVI-mediated activation cascade - PI3K alpha, beta, gamma convert PIP2 to PIP3 [Homo sapiens] - Cell surface interactions at the vascular wall - Tie2 Signaling - Interaction of Tie2 and p85 of PI3K [Homo sapiens] Signalling by NGF - NGF signalling via TRKA from the plasma membrane - PI3K/AKT signalling - Active IRS recruits PI3K to the plasma membrane and activates it [Homo sapiens] - PI3K produces PIP3 and other phosphatidyl inositides [Homo sapiens] Signaling by Insulin receptor - Insulin receptor signalling cascade - IRS-related events - IRS-mediated signalling - PI3K Cascade - PI3K activation [Homo sapiens] - PIP2 conversion to PIP3 [Homo sapiens] Signaling by PDGF - Down-stream signal transduction - PI3-kinase binds to the active receptor [Homo sapiens] - PI3K catalyses the phosphorylation of PIP2 to PIP3 [Homo sapiens] Signaling by FGFR - Downstream signaling of activated FGFR - PI-3K cascade - Activated FGFR binds PI3K [Homo sapiens] - PIP2 conversion to PIP3 [Homo sapiens]
Consumed by events	PI3K catalytic subunit binds to Gab1:Grb2:PI3K:EGF:EGFR [Homo sapiens]
Entities deduced on the basis of this entity	ENSCAFP00000016537 [cytosol] E E [Canis familiaris] P32871 [cytosol] U K E E G B C d R H R [Bos taurus] Ghost homologue of PI3K-p110 [cytosol] [Sus scrofa] P42337 [cytosol] U E E G B C d R H R [Mus musculus] Q91XL6 [cytosol] U E E G G B B C C d d [Rattus norvegicus] ENSRNOP00000037275 [cytosol] E E [Rattus norvegicus] Homologues of PI3K-p110 [cytosol] [Rattus norvegicus] O42391 [cytosol] U K E E G G G B B B C C C d d d R H R [Gallus gallus] ENSTGUP00000017733 [cytosol] E E [Taeniopygia guttata] ENSTGUP00000011093 [cytosol] E E [Taeniopygia guttata] Homologues of PI3K-p110 [cytosol] [Taeniopygia guttata] ENSXETP00000015756 [cytosol] E E [Xenopus tropicalis] ENSDARP00000103176 [cytosol] E E [Danio rerio] ENSDARP00000099309 [cytosol] E E [Danio rerio] Homologues of PI3K-p110 [cytosol] [Danio rerio] Q94125 [cytosol] U E W E G B C d R H R [Caenorhabditis elegans]

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