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name	phosphatidylinositol-4,5-bisphosphate 3-kinase activity
Accession	GO
Definition	Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate.
Enzyme Classification (EC) number	2.7.1.153 2.7.1.153
Molecules/complexes with this activity
CD28:PI3K [plasma membrane] EGF:Phospho-EGFR-GRB2:GAB1:PI3Kreg:PI3Kcat [cytosol] G-protein beta-gamma:PI3K gamma [plasma membrane] PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] PI3K alpha, beta, gamma [cytosol] PI3K bound to TRAT [plasma membrane]
Reactions catalysed by this activity
CD28 bound PI3K phosphorylates PIP2 to PIP3 [Homo sapiens] G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 [Homo sapiens] PI3K alpha, beta, gamma convert PIP2 to PIP3 [Homo sapiens] PI3K catalyses the phosphorylation of PIP2 to PIP3 [Homo sapiens] PI3K converts Phosphatidylinositol-4,5-bisphosphate to Phosphatidylinositol-3,4,5-trisphosphate [Homo sapiens] PI3K phosphorylates PIP2 to PIP3 [Homo sapiens] PI3K produces PIP3 and other phosphatidyl inositides [Homo sapiens]
Is a specialisation of activities
phosphoinositide 3-kinase activity GO lipid kinase activity GO kinase activity GO transferase activity, transferring phosphorus-containing groups GO transferase activity GO catalytic activity GO molecular_function GO inositol or phosphatidylinositol kinase activity GO kinase activity GO transferase activity, transferring phosphorus-containing groups GO transferase activity GO catalytic activity GO molecular_function GO phosphotransferase activity, alcohol group as acceptor GO transferase activity, transferring phosphorus-containing groups GO transferase activity GO catalytic activity GO molecular_function GO