PI3K phosphorylates PIP2 to PIP3 [Homo sapiens]
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PI3K phosphorylates PIP2 to PIP3
Stable identifierREACT_12561.1
AuthoredRudd, C.E., de Bono, B, Garapati, P V, 2008-01-24
ReviewedTrowsdale, J, 2008-02-26
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PI3K enzyme bound to adaptor protein TRIM, uses phosphatidylinositol 4,5-bisphosphate (PIP2) as its substrate and phosphorylates it to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). This PIP3 acts as a membrane anchor for the downstream proteins like PDK1 and PKB.
Input (present at start of reaction)Phosphatidylinositol-4,5-bisphosphate [plasma membrane] CC
ATP [cytosol] CCP
Output (present at end of reaction)Phosphatidylinositol-3,4,5-trisphosphate [plasma membrane] CC
ADP [cytosol] CCP
CatalystPI3K bound to TRAT [plasma membrane]
Essential catalyst componentPI3K-p110 [cytosol] UKEGOOOORHUR
GO molecular functionphosphatidylinositol-4,5-bisphosphate 3-kinase activity GO
Preceding event(s)Recruitment of PI3K to plasmamembrane [Homo sapiens]
Following event(s)PIP3 recruits PDK1 and AKT to the membrane [Homo sapiens]
Translocation of PDK1 to Plasma membrane [Homo sapiens]
Hydrolysis of PIP3 to PI(3,4)P2 [Homo sapiens]
Hydrolysis of PIP3 to PIP2 [Homo sapiens]
OrganismHomo sapiens
Cellular compartmentplasma membrane GO
References

Koyasu, S The role of PI3K in immune cells 2003 Nat Immunol PubMed

Equivalent event(s) in other organism(s)PI3K phosphorylates PIP2 to PIP3 [Mus musculus]
PI3K phosphorylates PIP2 to PIP3 [Rattus norvegicus]
PI3K phosphorylates PIP2 to PIP3 [Gallus gallus]
Participating molecules
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Date: 2010-02-09 00:29:21
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