Reactome news

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News
June 24, 2009 Version 29 Released Version 29 includes the new topic, Axon guidance, covering NCAM signaling in neurite outgrowth. Pathway topics updated with new curated events in this release include: Synaptic transmission (Glutamate Binding, Activation of AMPA Receptors, and Synaptic Plasticity), DNA Repair (regulation of FANCD2 and FANCI activity in the Fanconi Anemia pathway), and pathways related to diabetes (Regulation of insulin secretion and Unfolded protein response). With the annotation of receptors for eicosanoids, leukotrienes, nucleotide-like (purinergic) molecules, LPA and lysosphingolipids, opsins, secretins, and GABA and related molecules (class C/3 receptors), our annotation of interactions between G-coupled protein receptors (GPCRs) and their ligands is essentially complete. The Telomere Maintenance pathway has been revised in this release. T Huang, PF Maness, L Vosshall, and E Ziff are our external reviewers in this release. March 31, 2009 Version 28 Released New topics in Version 28 include signaling by PDGF, striated Muscle Contraction, and chaperonin-mediated protein folding and post-chaperonin tubulin folding. (grouped with translation and post-translational protein modification into a new "Metabolism of protein" super-pathway). Pathways updated with new curated events include GPCR signaling, (olfactory signaling, amine and hormone ligand-binding receptor events and additional peptide ligand-binding receptor events), synaptic transmission (Electrical transmission across Gap Junctions), hemostasis and signaling in the immune system (Tie2 signaling events and Basigin interactions. New metabolism topics include the peroxisomal metabolism of lipidsand glyoxylate and Integration of energy metabolism (Glucose Regulation of Insulin Secretion). N Cowan, CH Heldin, M Rush and L Vosshall are our external reviewers in this release. March 17, 2009 Version 1 of FlyReactome Released The first official version of FlyReactome has been released and is accessible at http://fly.reactome.org. This initial batch of curated Drosophila melanogaster signalling pathways presented in Version 1 include: Wingless, JAK/STAT, Imd, Toll, and Hedgehog. Appropriate links to the relevant Uniprot and FlyBase FBgn pages are provided. Future pathways to be included along with authored topics awaiting review can be found in the Editorial Calendar. December 17, 2008 Version 27 Released New topics released in Version 27 include Hormone biosynthesis grouping new curated material on peptide hormones with additional descriptions of prostanoid hormone events, Transmembrane transport of small molecules grouping new ABC transporter events along with existing transport reactions, Opiod signaling and Diabetes pathways including Insulin regulation and IGFBP- mediated events. The pathway topics updated with new curated events include: Signaling by GPCR (Olfactory receptor signaling and Receptor-ligand complexes that bind G-proteins), Integrin cell surface interaction (Integrin alphaIIbbeta3 signaling), Cell Cycle-G2/M transition (Centrosome maturation), Gene expression (tRNA Aminoacylation) , Metabolism of amino acids (Amino acid transport across the plasma membrane) and Signaling by NGF (calmodulin induced events). N Le Novere is our external author and A Antonellis, J Bockaert, L Castagnoli, L Freedman, A Merdes, SJ Shattil, and L Vosshall are our external reviewers in this release. Protein-protein interaction datasets, statistics and the editorial calendar are available. The Reactome team thanks users for their comments on the pathway visualization tool. Click on contact to reach us, on editorial to contribute to Reactome content, and on subscribe to receive Reactome announcements. September 30, 2008 Version 26 Released New topics released in Version 26 include: trans-Golgi network vesicle budding, Metabolism of polyamines and binding events that trigger signaling by GPCR . The pathway topics updated with new curated events include: Cell Cycle - Mitosis prometaphase, glucose metabolisms - gluconeogenesis, biological oxidations, transcriptional regulation, and transport processes related to carbohydrate and amino acids metabolism. J Bockaert, RA Harris, N Baker, M Rush, and IM Cheeseman are our external reviewers in this release. Protein-protein interaction datasets, statistics and the editorial calendar are available. The Reactome team thanks users for their comments on the pathway visualization tool. Click on contact to reach us, on editorial to contribute to Reactome content, and on subscribe to receive Reactome announcements. June 30, 2008 Version 25 Released An expanded and reorganized pathway module for Biological oxidations is available in this release. Other new additions to curated content include the pathway topics: Glutamate neurotransmitter release cycle, Beta cell development, and Integrin cell surface interactions. The pathway topics updated with new curated events include: Apoptosis - Regulatory reactions, Metabolism of amino acids - ODC regulation, Metabolism of Vitamins, NGF signaling, and Lipid Metabolism - HDL synthesis. A new project annotating Cellular Transport events has been initiated. A new look Search tool with features of popular search engines has been implemented. As usual, protein-protein interaction datasets, Statistics and the Editorial Calendar are available. Reactome team thanks the users for their comments on the pathway visualization tool. Click on contact to reach us, on editorial to contribute to Reactome content, and on subscribe to receive Reactome announcements. March 12, 2008 Version 24 Released New additions to curated content include the pathway topics: Signaling by VEGF, Metabolism of nitric oxide, and MicroRNA biogenesis. The pathway topics updated with new curated events include: Apoptosis - Cleavage reactions, Gene expression - Generic transcription pathway, Hemostasis - Tie2 and PECAM events, Immune signaling -TCR cascade, Energy metabolism - PDC regulation, Membrane Trafficking - COP II mediated events, Post translational modifications - Hypusine synthesis, EGFR signaling - PLC-gamma and Grb2 mediated downstream events. K Schulze-Osthoff, and L Castognoli are our external expert annotators, and S Ranganathan, LP Freedman, J Trowsdale, J Lippincott-Schwartz, G Enikolopov, F Karginov, GJ Hannon, CH Heldin, and L Claesson-Welsh are our external reviewers, in this release. As usual, protein-protein interaction datasets, Statistics and the Editorial Calendar are available. Reactome team thanks the users for their comments on the pathway visualization tool. Click on contact to reach us, on editorial to contribute to Reactome content, and on subscribe to receive Reactome announcements. December 11, 2007: Version 23 Released A new pathway visualization tool (beta version) is available with this release. The users are requested to send their feedback on this tool. Additions to curated content include the new signaling pathway, Signaling in BMP, Apoptotic execution phase module in Apoptosis, Cell Surface interactions module in Hemostasis, and the TRKA signaling module in NGF signaling. Pathway annotations from Reactome are now incorporated into the Pathway Interaction Database, a collaborative project between the US National Cancer Institute and Nature Publishing Group. As usual, protein-protein interaction datasets, Statistics and the Editorial Calendar are available. Click on contact to reach us, on editorial to contribute to Reactome content, and on subscribe to receive Reactome announcements. September 4, 2007: Version 22 Released New topics released in Version 22 include Botulinum neurotoxicity, Membrane trafficking and Metabolism of vitamins, pathways for HIV Nef protein interactions, Immunoregulatory interactions and AMPK regulation of fatty acid oxidation. A new tool, Reactome Mart, is available for comprehensive datamining. Reactome Wiki is available for editing documentation by the user community. As usual, protein-protein interaction datasets, Statistics and the Editorial Calendar are available. Click here to contact us. May 15, 2007: Version 21 Released New topics released in Version 21 include the Rho GTPase cycle, and Wnt regulation of beta-catenin, gap junction turnover, pathways for steroid hormone biosynthesis, metabolism of bile acids and bile salts and snRNP assembly. An outline of the entire influenza virus infection cycle has been completed. Statistics and the Editorial Calendar are available. Click here to contact us. February 28, 2007: Version 20 Released New topics released in Version 20 are Fibroblast Growth Factor Receptor (FGFR) signaling, Epidermal Growth Factor Receptor (EGFR) signaling under signaling pathways, Gap junction trafficking under cell biology, and Porphyrin metabolism, Digestion of dietary carbohydrate and lipid under metabolic pathways. Additional events for HIV REV protein interactions, and Influenza virus RNP assembly have been added to corresponding infectious disease pathways. Updated release statistics and the Editorial Calendar are available. Click here to contact us. November 16, 2006: Version 19 Released Version 19 marks the completion of "Early phase of HIV life cycle" with the release of Uncoating, Reverse Transcription and Integration under HIV Life Cycle. Other new modules include HIV Vpu protein interactions with host and Transport of Influenza virus RNPs into host nucleus under host pathogen interactions, signaling cascades mediated by Toll-like receptors 5,7/8,9-11, and cell cycle events mediated by p27/p21 proteins. A feature for version tracking using stable identifiers has been enabled. Updated release statistics and the Editorial Calendar are available. Click here to contact us. August 2, 2006: Version 18 Released New modules include the signaling cascade mediated by Toll-like receptor 2, Maintenance of Telomeres, Entry and Binding under HIV Life Cycle and the pathways of Complement Activation. Reactions and pathways chosen by the user are now highlighted prominently in the reaction map at the top of each web page. A new web display feature allows the user to choose the focus species annotations - curated (for human) and electronically inferred (for 22 other species). Stable identifiers have been introduced to facilitate the tracking of data objects over successive releases of Reactome. Updated release statistics and the Editorial Calendar are available. Click here to contact us. April 24, 2006: Version 17 Released New modules include signaling cascades mediated by TGF-beta, RIG-I, and Toll-like receptors 3 and 4, the conjugation phase of xenobiotic metabolism, aspects of the metabolism of lipoproteins, cell cycle regulation by the anaphase-promoting complex (APC), and ATR activation in response to replication stress. The SkyPainter tool now shows all reactions involving proteins in a user-specified list highlighted on the Reactome reaction map, lists these reactions in downloadable tabular form, and identifies pathways that are statistically over-represented for a list of specified proteins. Updated release statistics and the Editorial Calendar are available. Click here to contact us. January 23, 2006: Version 16 Released The release modules include four new pathways: framework annotations for Influenza and HIV infection cycles, details of the Electron Transport Chain and Insulin Receptor mediated signaling in Drosophila . Pathways and reactions can now be visualised with Cytoscape. Pathway descriptions and illustrations can be downloaded in PDF format. The SkyPainter tool now reports the reactions "touched" by query identifiers also in tabular format. Release statistics and the Editorial Calendar are available. Click here to contact us. September 26, 2005: Version 15 Released This version features a new module on the integration of energy metabolism, a revised data model that facilitates the organization of entities into meaningful classes, and a new,sensitive strategy for inference of orthologous events in fifteen model organisms. Release statistics are available here. The Editorial Calendar lists modules being prepared for the knowledgebase, their planned release dates, and contact information for module curators. September 7, 2005: Eighth Reactome Annotation Jamboree Experts in DNA Replication met at Cold Spring Harbor Laboratory to revise and expand the DNA Replication pathway in Reactome. August 1, 2005:Reactome Editorial Calendar The Editorial Calendar shows work now under way to expand the Reactome knowledgebase, organized by planned date of public release on this web site. The Calendar also shows the Reactome curator who is managing the work on each topic. For more information, including information about how you can participate in the Reactome editorial process,email the curator. July 21, 2005:New look for Reactome pathway and reaction pages Changes include collapsable panes, dynamic event hierarchy, and graphical representation of reactions. June 13, 2005: Version 14 Released New modules and subsections included in this release are Post-translational Modification of Proteins, Notch Signaling, Hormone-sensitive lipase added under Lipid Metabolism, Mitochondrial Transcription added under Transcription, MAPK Cascade added under Insulin Receptor Mediated Signaling, and Polo-like kinases added under Cell Cycle, Mitosis. For the full release statistics, please go to the Stats page. May 24, 2005: Seventh Reactome Annotation Jamboree Experts in the field of Retrovirus biology met at Cold Spring Harbor Laboratory to annotate the HIV life cycle for Reactome. April 11, 2005: Version 13 Release New modules added include Translation Elongation, mRNA Transport, and Fibrinolysis and Intrinsic Pathway for the formation of blood clots. We now link to OMIM and KEGG. Stats. February 1, 2005: Reactome version 12 released Three new modules - mitotic spindle checkpoint, termination of protein translation, and xenobiotic (drug) metabolism - were added. Several others were updated, most notably the initiation of protein translation and mRNA processing modules. The updated numbers of proteins, complexes, reactions, and pathways can be found on the stats page. January 31, 2005: Franklin Award for Ewan Birney The honor of the Benjamin Franklin Award in Bioinformatics for 2005 has been accorded to Ewan Birney. January 3, 2005: SkyPainter 2 The Reactome SkyPainter tool allows the overlay of protein or gene identifiers on the reaction map.SkyPainter 2 now available at the Reactome site, also lets users visualize microarray data overlaid on the reaction map, including time series data. December 31, 2004: New Reactome publication Free access to full text for the Reactome manuscript is available in the 2005 Database Issue of Nucleic Acids Research. October 27, 2004: 11th Release of Reactome New modules released today are Apoptosis and Hemostasis. October 12, 2004: Reactome now downloadable in SBML format Human reactions in Reactome can now be downloaded in SBML format. Also, SBML version of Reactome events is available at the bottom of each event page. October 7, 2004: New Reactome tools available for download Two java tools are now available for download. The author tool is designed for biologists to input data into Reactome, while the curator tool is meant for use by curators to annotate biological pathways based on the Reactome schema. September 8, 2004: Sixth Reactome Annotation Jamboree Protein translation experts met at Cold Spring Harbor Laboratory, and annotated for Reactome to augment the existing module on translation, and to add the regulatory reactions July 7, 2004: Second Reactome Scientific Advisory Board Meeting The Reactome Scientific Advisory Board met with the Reactome Team at Cold Spring Harbor Laboratory July 6, 2004: Reactome Version 10 Released Modules released today include DNA Damage Reversal, Elongation and Termination of Transcription for RNA Polymerase II and III, Gene expression, Transcription Activation by E2F in the G1/S transition of the cell cycle, Processing of intronless mRNAs, both histone(SLBP dependent and independent pathways) and non-histone mRNAs. Updates were made to Nucleotide Metabolism and Cell Cycle. Orthology predictions now also extend to chicken. June 2, 2004: Reactome launched Genome Knowledgebase renamed to Reactome. The new web site also features a radically redesigned user interface for pathway visualization and navigation. May 27, 2004: GK paper A paper to cite Genome Knowledgebase can be downloaded as a pdf document. May 19, 2004: Fifth GK Annotation Jamboree Cell cycle experts met at Cold Spring Harbor Laboratory, and annotated for GK to fill gaps in Mitosis and E2F activation March, 11, 2004: Bioinformatics Awards for Lincoln Stein Lincoln Stein has been named the 2004 laureate of the Benjamin Franklin Award in Bioinformatics. He has also been featured by Genome Technology Magazine as "Most Innovative in Biotechnology". March, 6, 2004: GK Version 8 release Several new modules added - DNA Repair now includes Base Excision Repair, DNA Damage Bypass, Homologous Recombination Repair, and Nucleotide Excision Repair; Beta Oxidation of Unsaturated Fatty Acids added to Lipid Metabolism; Nucleotide Metabolism with added Transport Processes; Transcription now also includes Initiation of transcription by RNA Polymerase II. Proteins now have cross-references to LocusLink and Ensembl genes. December 18, 2003: GK Version 7 release Three new modules added in GK Version 7 - mRNA editing, U12 Dependent mRNA splicing, and RNA Polymerase III Transcription Initiation. December 4, 2003: Fourth GK Annotation Jamboree Insulin Signalling experts in three non-human systems - worm, fly, and mouse - met in London to annotate for GK. This is a first attempt to use GK for comparative biology. November 3, 2003: GK Version 6 release Features five new modules - Insulin Receptor Activation and Recycling, Lipid Metabolism (includes Triglyceride Biosynthesis, beta Oxidation of Saturated Fatty Acids, & Ketone Body Metabolism), mRNA Capping (under mRNA Processing), Non-Homologous End-Joining, and Purine Metabolism (under Nucleotide Metabolism). September 18, 2003: Third GK Annotation Jamboree Apoptosis experts met at Cold Spring Harbor Laboratory, and annotated for GK September 5, 2003: GK Version 5 release This release features two new modules - RNA Polymerase I Transcription and Pyrimidine Metabolism, and updates to the Cell Cycle & Cell Cycle Checkpoints modules. Small schema changes, and information on linking to GK is also provided. August 28, 2003: Second GK Annotation Jamboree Experts in Transcription and mRNA capping met at Cold Spring Harbor Laboratory, and annotated for GK August 20, 2003: First GK Annotation Jamboree Biology experts in the area of Gene Expression met at Cold Spring Harbor Laboratory to annotate for GK May 31, 2003: GK at the 68th CSHL Symposium Lincoln Stein presented the GK project at the 68th Cold Spring Harbor Symposium on Quantitative Biology: The Genome of the Homo Sapiens, as part of the 50th Anniversary celebrations for the discovery of the double helix May 22, 2003: Pathfinder tool now available The Pathfinder tool lets the user find a path between two molecules or complexes in GK, if such a path exists. May 9, 2003: GK Scientific Advisory Board Meeting A meeting of the full Scientific Advisory Board for the GK project, to assess progress, and to chart the path forward. May 4, 2003: Version 4 Features several new modules under Metabolic Pathways, Cell Cycle, Cell Cycle Checkpoints, and Processing of mRNA. We now link to predicted model organism reactions based on orthologues. March 6, 2003: GK Version 3 release This is a minor release, featuring one new topic and small schema changes. February 3, 2003: GK project seeking more authors and reviewers We are now seeking authors and reviewers for contribution to the topics of Cell Cycle and Cell Cycle Checkpoints, and RNA splicing. February 3, 2003: GK Version 2 released The second major release of Genome KnowledgeBase features a new user interface design and eight new modules. December 10, 2002: GK project Receives $400,000 Subcontract from Consortium The Genome Knowledgebase is pleased to announce that the Cell Migration Consortium has granted it a two-year subcontract to develop authoring and editing tools for cellular pathways involved in cell migration and motility. December 1, 2002: Protein Translation An early version of the Protein Translation module is now available for review. September 8, 2002: Imre Vastrik presents GK at Ontology Conference GK project chief software architect Imre Vastrik gave attendees at the Genome Informatics meeting in Hinxton, UK a sneak preview of the new user interface for the Genome Knowledgebase.

News

June 24, 2009 Version 29 Released
Version 29 includes the new topic, Axon guidance, covering NCAM signaling in neurite outgrowth. Pathway topics updated with new curated events in this release include: Synaptic transmission (Glutamate Binding, Activation of AMPA Receptors, and Synaptic Plasticity), DNA Repair (regulation of FANCD2 and FANCI activity in the Fanconi Anemia pathway), and pathways related to diabetes (Regulation of insulin secretion and Unfolded protein response). With the annotation of receptors for eicosanoids, leukotrienes, nucleotide-like (purinergic) molecules, LPA and lysosphingolipids, opsins, secretins, and GABA and related molecules (class C/3 receptors), our annotation of interactions between G-coupled protein receptors (GPCRs) and their ligands is essentially complete. The Telomere Maintenance pathway has been revised in this release.
T Huang, PF Maness, L Vosshall, and E Ziff are our external reviewers in this release.
March 31, 2009 Version 28 Released
New topics in Version 28 include signaling by PDGF, striated Muscle Contraction, and chaperonin-mediated protein folding and post-chaperonin tubulin folding. (grouped with translation and post-translational protein modification into a new "Metabolism of protein" super-pathway). Pathways updated with new curated events include GPCR signaling, (olfactory signaling, amine and hormone ligand-binding receptor events and additional peptide ligand-binding receptor events), synaptic transmission (Electrical transmission across Gap Junctions), hemostasis and signaling in the immune system (Tie2 signaling events and Basigin interactions. New metabolism topics include the peroxisomal metabolism of lipidsand glyoxylate and Integration of energy metabolism (Glucose Regulation of Insulin Secretion).
N Cowan, CH Heldin, M Rush and L Vosshall are our external reviewers in this release.
March 17, 2009 Version 1 of FlyReactome Released
The first official version of FlyReactome has been released and is accessible at http://fly.reactome.org.
This initial batch of curated Drosophila melanogaster signalling pathways presented in Version 1 include: Wingless, JAK/STAT, Imd, Toll, and Hedgehog. Appropriate links to the relevant Uniprot and FlyBase FBgn pages are provided. Future pathways to be included along with authored topics awaiting review can be found in the Editorial Calendar.
December 17, 2008 Version 27 Released
New topics released in Version 27 include Hormone biosynthesis grouping new curated material on peptide hormones with additional descriptions of prostanoid hormone events, Transmembrane transport of small molecules grouping new ABC transporter events along with existing transport reactions, Opiod signaling and Diabetes pathways including Insulin regulation and IGFBP- mediated events. The pathway topics updated with new curated events include: Signaling by GPCR (Olfactory receptor signaling and Receptor-ligand complexes that bind G-proteins), Integrin cell surface interaction (Integrin alphaIIbbeta3 signaling), Cell Cycle-G2/M transition (Centrosome maturation), Gene expression (tRNA Aminoacylation) , Metabolism of amino acids (Amino acid transport across the plasma membrane) and Signaling by NGF (calmodulin induced events).
N Le Novere is our external author and A Antonellis, J Bockaert, L Castagnoli, L Freedman, A Merdes, SJ Shattil, and L Vosshall are our external reviewers in this release.
Protein-protein interaction datasets, statistics and the editorial calendar are available. The Reactome team thanks users for their comments on the pathway visualization tool.
Click on contact to reach us, on editorial to contribute to Reactome content, and on subscribe to receive Reactome announcements.
September 30, 2008 Version 26 Released
New topics released in Version 26 include: trans-Golgi network vesicle budding, Metabolism of polyamines and binding events that trigger signaling by GPCR . The pathway topics updated with new curated events include: Cell Cycle - Mitosis prometaphase, glucose metabolisms - gluconeogenesis, biological oxidations, transcriptional regulation, and transport processes related to carbohydrate and amino acids metabolism.
J Bockaert, RA Harris, N Baker, M Rush, and IM Cheeseman are our external reviewers in this release.
Protein-protein interaction datasets, statistics and the editorial calendar are available. The Reactome team thanks users for their comments on the pathway visualization tool.
Click on contact to reach us, on editorial to contribute to Reactome content, and on subscribe to receive Reactome announcements.
June 30, 2008 Version 25 Released
An expanded and reorganized pathway module for Biological oxidations is available in this release. Other new additions to curated content include the pathway topics: Glutamate neurotransmitter release cycle, Beta cell development, and Integrin cell surface interactions. The pathway topics updated with new curated events include: Apoptosis - Regulatory reactions, Metabolism of amino acids - ODC regulation, Metabolism of Vitamins, NGF signaling, and Lipid Metabolism - HDL synthesis. A new project annotating Cellular Transport events has been initiated. A new look Search tool with features of popular search engines has been implemented.
As usual, protein-protein interaction datasets, Statistics and the Editorial Calendar are available. Reactome team thanks the users for their comments on the pathway visualization tool.
Click on contact to reach us, on editorial to contribute to Reactome content, and on subscribe to receive Reactome announcements.
March 12, 2008 Version 24 Released
New additions to curated content include the pathway topics: Signaling by VEGF, Metabolism of nitric oxide, and MicroRNA biogenesis. The pathway topics updated with new curated events include: Apoptosis - Cleavage reactions, Gene expression - Generic transcription pathway, Hemostasis - Tie2 and PECAM events, Immune signaling -TCR cascade, Energy metabolism - PDC regulation, Membrane Trafficking - COP II mediated events, Post translational modifications - Hypusine synthesis, EGFR signaling - PLC-gamma and Grb2 mediated downstream events.
K Schulze-Osthoff, and L Castognoli are our external expert annotators, and S Ranganathan, LP Freedman, J Trowsdale, J Lippincott-Schwartz, G Enikolopov, F Karginov, GJ Hannon, CH Heldin, and L Claesson-Welsh are our external reviewers, in this release.
As usual, protein-protein interaction datasets, Statistics and the Editorial Calendar are available. Reactome team thanks the users for their comments on the pathway visualization tool.
Click on contact to reach us, on editorial to contribute to Reactome content, and on subscribe to receive Reactome announcements.
December 11, 2007: Version 23 Released
A new pathway visualization tool (beta version) is available with this release. The users are requested to send their feedback on this tool. Additions to curated content include the new signaling pathway, Signaling in BMP, Apoptotic execution phase module in Apoptosis, Cell Surface interactions module in Hemostasis, and the TRKA signaling module in NGF signaling. Pathway annotations from Reactome are now incorporated into the Pathway Interaction Database, a collaborative project between the US National Cancer Institute and Nature Publishing Group.
As usual, protein-protein interaction datasets, Statistics and the Editorial Calendar are available. Click on contact to reach us, on editorial to contribute to Reactome content, and on subscribe to receive Reactome announcements.
September 4, 2007: Version 22 Released
New topics released in Version 22 include Botulinum neurotoxicity, Membrane trafficking and Metabolism of vitamins, pathways for HIV Nef protein interactions, Immunoregulatory interactions and AMPK regulation of fatty acid oxidation. A new tool, Reactome Mart, is available for comprehensive datamining. Reactome Wiki is available for editing documentation by the user community. As usual, protein-protein interaction datasets, Statistics and the Editorial Calendar are available. Click here to contact us.
May 15, 2007: Version 21 Released
New topics released in Version 21 include the Rho GTPase cycle, and Wnt regulation of beta-catenin, gap junction turnover, pathways for steroid hormone biosynthesis, metabolism of bile acids and bile salts and snRNP assembly. An outline of the entire influenza virus infection cycle has been completed. Statistics and the Editorial Calendar are available. Click here to contact us.
February 28, 2007: Version 20 Released
New topics released in Version 20 are Fibroblast Growth Factor Receptor (FGFR) signaling, Epidermal Growth Factor Receptor (EGFR) signaling under signaling pathways, Gap junction trafficking under cell biology, and Porphyrin metabolism, Digestion of dietary carbohydrate and lipid under metabolic pathways. Additional events for HIV REV protein interactions, and Influenza virus RNP assembly have been added to corresponding infectious disease pathways. Updated release statistics and the Editorial Calendar are available. Click here to contact us.
November 16, 2006: Version 19 Released
Version 19 marks the completion of "Early phase of HIV life cycle" with the release of Uncoating, Reverse Transcription and Integration under HIV Life Cycle. Other new modules include HIV Vpu protein interactions with host and Transport of Influenza virus RNPs into host nucleus under host pathogen interactions, signaling cascades mediated by Toll-like receptors 5,7/8,9-11, and cell cycle events mediated by p27/p21 proteins. A feature for version tracking using stable identifiers has been enabled. Updated release statistics and the Editorial Calendar are available. Click here to contact us.
August 2, 2006: Version 18 Released
New modules include the signaling cascade mediated by Toll-like receptor 2, Maintenance of Telomeres, Entry and Binding under HIV Life Cycle and the pathways of Complement Activation. Reactions and pathways chosen by the user are now highlighted prominently in the reaction map at the top of each web page. A new web display feature allows the user to choose the focus species annotations - curated (for human) and electronically inferred (for 22 other species). Stable identifiers have been introduced to facilitate the tracking of data objects over successive releases of Reactome. Updated release statistics and the Editorial Calendar are available. Click here to contact us.
April 24, 2006: Version 17 Released
New modules include signaling cascades mediated by TGF-beta, RIG-I, and Toll-like receptors 3 and 4, the conjugation phase of xenobiotic metabolism, aspects of the metabolism of lipoproteins, cell cycle regulation by the anaphase-promoting complex (APC), and ATR activation in response to replication stress. The SkyPainter tool now shows all reactions involving proteins in a user-specified list highlighted on the Reactome reaction map, lists these reactions in downloadable tabular form, and identifies pathways that are statistically over-represented for a list of specified proteins. Updated release statistics and the Editorial Calendar are available. Click here to contact us.

January 23, 2006: Version 16 Released
The release modules include four new pathways: framework annotations for Influenza and HIV infection cycles, details of the Electron Transport Chain and Insulin Receptor mediated signaling in Drosophila . Pathways and reactions can now be visualised with Cytoscape. Pathway descriptions and illustrations can be downloaded in PDF format. The SkyPainter tool now reports the reactions "touched" by query identifiers also in tabular format. Release statistics and the Editorial Calendar are available. Click here to contact us.

September 26, 2005: Version 15 Released
This version features a new module on the integration of energy metabolism, a revised data model that facilitates the organization of entities into meaningful classes, and a new,sensitive strategy for inference of orthologous events in fifteen model organisms. Release statistics are available here. The Editorial Calendar lists modules being prepared for the knowledgebase, their planned release dates, and contact information for module curators.

September 7, 2005: Eighth Reactome Annotation Jamboree
Experts in DNA Replication met at Cold Spring Harbor Laboratory to revise and expand the DNA Replication pathway in Reactome.

August 1, 2005:Reactome Editorial Calendar
The Editorial Calendar shows work now under way to expand the Reactome knowledgebase, organized by planned date of public release on this web site. The Calendar also shows the Reactome curator who is managing the work on each topic. For more information, including information about how you can participate in the Reactome editorial process,email the curator.

July 21, 2005:New look for Reactome pathway and reaction pages
Changes include collapsable panes, dynamic event hierarchy, and graphical representation of reactions.

June 13, 2005: Version 14 Released
New modules and subsections included in this release are Post-translational Modification of Proteins, Notch Signaling, Hormone-sensitive lipase added under Lipid Metabolism, Mitochondrial Transcription added under Transcription, MAPK Cascade added under Insulin Receptor Mediated Signaling, and Polo-like kinases added under Cell Cycle, Mitosis. For the full release statistics, please go to the Stats page.

May 24, 2005: Seventh Reactome Annotation Jamboree
Experts in the field of Retrovirus biology met at Cold Spring Harbor Laboratory to annotate the HIV life cycle for Reactome.

April 11, 2005: Version 13 Release
New modules added include Translation Elongation, mRNA Transport, and Fibrinolysis and Intrinsic Pathway for the formation of blood clots. We now link to OMIM and KEGG. Stats.

February 1, 2005: Reactome version 12 released
Three new modules - mitotic spindle checkpoint, termination of protein translation, and xenobiotic (drug) metabolism - were added. Several others were updated, most notably the initiation of protein translation and mRNA processing modules. The updated numbers of proteins, complexes, reactions, and pathways can be found on the stats page.

January 31, 2005: Franklin Award for Ewan Birney
The honor of the Benjamin Franklin Award in Bioinformatics for 2005 has been accorded to Ewan Birney.

January 3, 2005: SkyPainter 2
The Reactome SkyPainter tool allows the overlay of protein or gene identifiers on the reaction map.SkyPainter 2 now available at the Reactome site, also lets users visualize microarray data overlaid on the reaction map, including time series data.

December 31, 2004: New Reactome publication
Free access to full text for the Reactome manuscript is available in the 2005 Database Issue of Nucleic Acids Research.

October 27, 2004: 11th Release of Reactome
New modules released today are Apoptosis and Hemostasis.

October 12, 2004: Reactome now downloadable in SBML format
Human reactions in Reactome can now be downloaded in SBML format. Also, SBML version of Reactome events is available at the bottom of each event page.

October 7, 2004: New Reactome tools available for download
Two java tools are now available for download. The author tool is designed for biologists to input data into Reactome, while the curator tool is meant for use by curators to annotate biological pathways based on the Reactome schema.

September 8, 2004: Sixth Reactome Annotation Jamboree
Protein translation experts met at Cold Spring Harbor Laboratory, and annotated for Reactome to augment the existing module on translation, and to add the regulatory reactions

July 7, 2004: Second Reactome Scientific Advisory Board Meeting
The Reactome Scientific Advisory Board met with the Reactome Team at Cold Spring Harbor Laboratory

July 6, 2004: Reactome Version 10 Released
Modules released today include DNA Damage Reversal, Elongation and Termination of Transcription for RNA Polymerase II and III, Gene expression, Transcription Activation by E2F in the G1/S transition of the cell cycle, Processing of intronless mRNAs, both histone(SLBP dependent and independent pathways) and non-histone mRNAs. Updates were made to Nucleotide Metabolism and Cell Cycle. Orthology predictions now also extend to chicken.

June 2, 2004: Reactome launched
Genome Knowledgebase renamed to Reactome. The new web site also features a radically redesigned user interface for pathway visualization and navigation.

May 27, 2004: GK paper
A paper to cite Genome Knowledgebase can be downloaded as a pdf document.

May 19, 2004: Fifth GK Annotation Jamboree
Cell cycle experts met at Cold Spring Harbor Laboratory, and annotated for GK to fill gaps in Mitosis and E2F activation

March, 11, 2004: Bioinformatics Awards for Lincoln Stein
Lincoln Stein has been named the 2004 laureate of the Benjamin Franklin Award in Bioinformatics. He has also been featured by Genome Technology Magazine as "Most Innovative in Biotechnology".

March, 6, 2004: GK Version 8 release
Several new modules added - DNA Repair now includes Base Excision Repair, DNA Damage Bypass, Homologous Recombination Repair, and Nucleotide Excision Repair; Beta Oxidation of Unsaturated Fatty Acids added to Lipid Metabolism; Nucleotide Metabolism with added Transport Processes; Transcription now also includes Initiation of transcription by RNA Polymerase II. Proteins now have cross-references to LocusLink and Ensembl genes.

December 18, 2003: GK Version 7 release
Three new modules added in GK Version 7 - mRNA editing, U12 Dependent mRNA splicing, and RNA Polymerase III Transcription Initiation.

December 4, 2003: Fourth GK Annotation Jamboree
Insulin Signalling experts in three non-human systems - worm, fly, and mouse - met in London to annotate for GK. This is a first attempt to use GK for comparative biology.

November 3, 2003: GK Version 6 release
Features five new modules - Insulin Receptor Activation and Recycling, Lipid Metabolism (includes Triglyceride Biosynthesis, beta Oxidation of Saturated Fatty Acids, & Ketone Body Metabolism), mRNA Capping (under mRNA Processing), Non-Homologous End-Joining, and Purine Metabolism (under Nucleotide Metabolism).

September 18, 2003: Third GK Annotation Jamboree
Apoptosis experts met at Cold Spring Harbor Laboratory, and annotated for GK

September 5, 2003: GK Version 5 release
This release features two new modules - RNA Polymerase I Transcription and Pyrimidine Metabolism, and updates to the Cell Cycle & Cell Cycle Checkpoints modules. Small schema changes, and information on linking to GK is also provided.

August 28, 2003: Second GK Annotation Jamboree
Experts in Transcription and mRNA capping met at Cold Spring Harbor Laboratory, and annotated for GK

August 20, 2003: First GK Annotation Jamboree
Biology experts in the area of Gene Expression met at Cold Spring Harbor Laboratory to annotate for GK

May 31, 2003: GK at the 68th CSHL Symposium
Lincoln Stein presented the GK project at the 68th Cold Spring Harbor Symposium on Quantitative Biology: The Genome of the Homo Sapiens, as part of the 50th Anniversary celebrations for the discovery of the double helix

May 22, 2003: Pathfinder tool now available
The Pathfinder tool lets the user find a path between two molecules or complexes in GK, if such a path exists.

May 9, 2003: GK Scientific Advisory Board Meeting
A meeting of the full Scientific Advisory Board for the GK project, to assess progress, and to chart the path forward.

May 4, 2003: Version 4
Features several new modules under Metabolic Pathways, Cell Cycle, Cell Cycle Checkpoints, and Processing of mRNA. We now link to predicted model organism reactions based on orthologues.

March 6, 2003: GK Version 3 release
This is a minor release, featuring one new topic and small schema changes.

February 3, 2003: GK project seeking more authors and reviewers
We are now seeking authors and reviewers for contribution to the topics of Cell Cycle and Cell Cycle Checkpoints, and RNA splicing.

February 3, 2003: GK Version 2 released
The second major release of Genome KnowledgeBase features a new user interface design and eight new modules.

December 10, 2002: GK project Receives $400,000 Subcontract from Consortium
The Genome Knowledgebase is pleased to announce that the Cell Migration Consortium has granted it a two-year subcontract to develop authoring and editing tools for cellular pathways involved in cell migration and motility.

December 1, 2002: Protein Translation
An early version of the Protein Translation module is now available for review.

September 8, 2002: Imre Vastrik presents GK at Ontology Conference
GK project chief software architect Imre Vastrik gave attendees at the Genome Informatics meeting in Hinxton, UK a sneak preview of the new user interface for the Genome Knowledgebase.